Neural Cell News Volume 16.07 | Feb 23 2022

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    2022-02-23 | NCN 16.07


    Neural Cell News by STEMCELL Technologies
    Vol. 16.07 – 23 February, 2022
    TOP STORY

    USP33 Deubiquitinates and Stabilizes HIF-2alpha to Promote Hypoxia Response in Glioma Stem Cells

    USP33 was preferentially induced in glioma stem cells by hypoxia and interacted with HIF-2alpha, leading to its stabilization through deubiquitination.
    [EMBO Journal]

    AbstractGraphical Abstract
    Virtual Poster Presentation: CRISPR-Cas9 Gene Editing of Cerebral Organoids to Model Microcephaly
    PUBLICATIONSRanked by the impact factor of the journal

    O-GlcNAc Transferase Regulates Glioblastoma Acetate Metabolism via Regulation of CDK5-Dependent ACSS2 Phosphorylation

    O-GlcNAc transferase was required and sufficient for glioblastoma cell growth and regulated acetate conversion to acetyl-CoA and lipids.
    [Oncogene]

    Abstract

    A Novel TanCAR Targeting IL13Rα2 and EphA2 for Enhanced Glioblastoma Therapy

    To improve chimeric antigen receptor T cell (CAR-T) therapy for glioblastoma, a new TanCAR, comprising the tandem arrangement of IL13 and EphA2 scFv, was generated and validated in vitro and in vivo.
    [Molecular Therapy Oncolytics]

    AbstractFull ArticleGraphical Abstract

    Autophagy-Based Unconventional Secretion of HMGB1 in Glioblastoma Promotes Chemosensitivity to Temozolomide through Macrophage M1-Like Polarization

    The authors demonstrated that enhanced secretory autophagy in glioblastoma (GB) facilitated M1-like polarization of tumor associated macrophages to enhance temozolomide sensitivity of GB cells.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    SEDT2 Palmitoylation Mediated by ZDHHC16 in EGFR-Mutated Glioblastoma Promotes Ionizing Radiation-Induced DNA Damage

    Researchers presented novel mechanistic evidence relating to signaling pathways with DNA damage responses in epidermal growth factor receptor-mutated glioblastoma multiforme.
    [International Journal of Radiation Oncology Biology Physics]

    Abstract

    The Mfn1-βIIPKC Interaction Regulates Mitochondrial Dysfunction via Sirt3 Following Experimental Subarachnoid Hemorrhage

    Scientists investigated the role of Mfn1-βIIPKC interaction in brain damage and neurological function in both in vivo and in vitro experimental subarachnoid hemorrhage models.
    [Translational Stroke Research]

    Abstract

    ChK1 Activation Induces Reactive Astrogliosis through CIP2A/PP2A/STAT3 Pathway in Alzheimer’s Disease

    Checkpoint kinase 1 (ChK1)-mediated Cancerous Inhibitor of PP2A (CIP2A) overexpression drove inhibition of PP2A and activated STAT3, then led to reactive astrogliosis and neurodegeneration in vitro.
    [FASEB Journal]

    Abstract

    Vitamin D Receptor Activation Attenuates Hippo Pathway Effectors and Cell Survival in Metastatic Neuroblastoma

    To discover new neuroblastoma therapies, investigators utilized the Connectivity Map to identify compounds that could reverse the metastatic transcriptional signature and found calcipotriol, a Vitamin D3 analog, to be a compound that selectively targets cell lines with enhanced metastatic potential.
    [Molecular Cancer Research]

    AbstractFull Article

    Chlamydia pneumoniae Can Infect the Central Nervous System via the Olfactory and Trigeminal Nerves and Contributes to Alzheimer’s Disease Risk

    The nerves extending between the nasal cavity and the brain constituted invasion paths by which C. pneumoniae could rapidly invade the central nervous system likely by surviving in glia and leading to Aβ deposition.
    [Scientific Reports]

    Full ArticlePress Release

    Bone Morphogenetic Protein Receptor Inhibitors Suppress the Growth of Glioblastoma Cells

    Scientists utilized bone morphogenetic protein (BMP) inhibitors DMH1, JL5, and Ym155 to examine the role of BMP signaling on the growth of glioblastomas.
    [Molecular and Cellular Biochemistry]

    Abstract
    Use STEMvisionâ„¢ for Automated Hematopoietic CFU Assay Imaging & Analysis.
    REVIEWS

    The Role of Glial Cells in Multiple Sclerosis Disease Progression

    The authors provide an overview of the involvement of astrocytes and microglia at major sites of pathology in progressive multiple sclerosis.
    [Nature Reviews Neurology]

    Abstract

    How Do Protein Aggregates Escape Quality Control in Neurodegeneration?

    Scientists examine recent advances in amyloid fibril structures and the process of fibril formation via phase separation, which are shedding new light on the role of protein quality control in protein aggregation diseases.
    [Trends in Neurosciences]

    Abstract

    Cellular Senescence in Neuroblastoma

    Investigators summarize the molecular knowledge about cellular senescence in neuroblastoma and investigate current and future options towards therapeutic exploration.
    [British Journal of Cancer]

    Abstract
    INDUSTRY AND POLICY NEWS

    Acticor Biotech Announces Positive Results From Its ACTIMIS PHASE Ib/IIa Study in Patients With Acute Ischemic Stroke (AIS)

    Acticor Biotech announced positive results from its ACTIMIS Phase Ib/IIa clinical trial using glenzocimab as an add-on to standard of care in patients with AIS.
    [Acticor Biotech]

    Press Release

    4D Pharma Announces FDA Clearance of IND Application for Live Biotherapeutics MRx0005 and MRx0029 for the Treatment of Parkinson’s Disease

    4D pharma plc announced that the US FDA has cleared investigational new drug (IND) applications for two live biotherapeutics, MRx0005 and MRx0029, for the treatment of Parkinson’s disease.
    [4D pharma plc]

    Press Release
    FEATURED EVENT

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    JOB OPPORTUNITIES

    PhD Position – iPSC-Based Neuronal Transplants

    University Hospital Bonn – Bonn, Germany

    Lead Researcher – Neural Progenitor Cells

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Postdoctoral Fellow – Neurogenomics Lab

    Harvard Medical School – Boston, Massachusetts, United States

    Research Associate – Neural Stem Cells

    NC State University – Raleigh, North Carolina, United States

    Senior Researcher – Neurobiology

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

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