| Vol. 16.07 – 23 February, 2022 |
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| USP33 was preferentially induced in glioma stem cells by hypoxia and interacted with HIF-2alpha, leading to its stabilization through deubiquitination. [EMBO Journal] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| O-GlcNAc transferase was required and sufficient for glioblastoma cell growth and regulated acetate conversion to acetyl-CoA and lipids. [Oncogene] |
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| To improve chimeric antigen receptor T cell (CAR-T) therapy for glioblastoma, a new TanCAR, comprising the tandem arrangement of IL13 and EphA2 scFv, was generated and validated in vitro and in vivo. [Molecular Therapy Oncolytics] |
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| The authors demonstrated that enhanced secretory autophagy in glioblastoma (GB) facilitated M1-like polarization of tumor associated macrophages to enhance temozolomide sensitivity of GB cells. [Journal of Experimental & Clinical Cancer Research] |
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| Researchers presented novel mechanistic evidence relating to signaling pathways with DNA damage responses in epidermal growth factor receptor-mutated glioblastoma multiforme. [International Journal of Radiation Oncology Biology Physics] |
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| Scientists investigated the role of Mfn1-βIIPKC interaction in brain damage and neurological function in both in vivo and in vitro experimental subarachnoid hemorrhage models. [Translational Stroke Research] |
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| Checkpoint kinase 1 (ChK1)-mediated Cancerous Inhibitor of PP2A (CIP2A) overexpression drove inhibition of PP2A and activated STAT3, then led to reactive astrogliosis and neurodegeneration in vitro. [FASEB Journal] |
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| To discover new neuroblastoma therapies, investigators utilized the Connectivity Map to identify compounds that could reverse the metastatic transcriptional signature and found calcipotriol, a Vitamin D3 analog, to be a compound that selectively targets cell lines with enhanced metastatic potential. [Molecular Cancer Research] |
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| The nerves extending between the nasal cavity and the brain constituted invasion paths by which C. pneumoniae could rapidly invade the central nervous system likely by surviving in glia and leading to Aβ deposition. [Scientific Reports] |
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| Scientists utilized bone morphogenetic protein (BMP) inhibitors DMH1, JL5, and Ym155 to examine the role of BMP signaling on the growth of glioblastomas. [Molecular and Cellular Biochemistry] |
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| The authors provide an overview of the involvement of astrocytes and microglia at major sites of pathology in progressive multiple sclerosis. [Nature Reviews Neurology] |
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| Scientists examine recent advances in amyloid fibril structures and the process of fibril formation via phase separation, which are shedding new light on the role of protein quality control in protein aggregation diseases. [Trends in Neurosciences] |
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| Investigators summarize the molecular knowledge about cellular senescence in neuroblastoma and investigate current and future options towards therapeutic exploration. [British Journal of Cancer] |
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| Acticor Biotech announced positive results from its ACTIMIS Phase Ib/IIa clinical trial using glenzocimab as an add-on to standard of care in patients with AIS. [Acticor Biotech] |
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| 4D pharma plc announced that the US FDA has cleared investigational new drug (IND) applications for two live biotherapeutics, MRx0005 and MRx0029, for the treatment of Parkinson’s disease. [4D pharma plc] |
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| March 20 – 25, 2022 Ventura, California, United States |
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| University Hospital Bonn – Bonn, Germany |
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| St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| Harvard Medical School – Boston, Massachusetts, United States |
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| NC State University – Raleigh, North Carolina, United States |
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| St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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