 | | Vol. 16.08 – 2 March, 2022 |
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| Loss of TDP-43 from the nucleus in human brain, neuronal cell lines and motor neurons derived from induced pluripotent stem cells resulted in the inclusion of a cryptic exon in UNC13A mRNA and reduced UNC13A protein expression.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| In neuronal models of Alzheimer’s disease (AD), the 5XFAD mouse model and post-mortem AD brains, ATAD3A was oligomerized and accumulated at the mitochondria-associated endoplasmic reticulum membranes.
[Nature Communications] |
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| Investigators reinforced the connection between aberrant cytosolic-to-endoplasmic reticulum acetyl-CoA flux and the development of an autistic-like phenotype.
[Brain] |
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| The authors developed a platform integrated with a newly curated tumor surfaceome classifier that allowed profiling of primary 3D cultures and intact patient glioma tumors with preserved tissue architecture.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists revealed the mechanism by which PCNA clamp-associated factor (PCLAF) facilitated cell cycle progression and recommended that the PCLAF/E2F1/PTTG1 axis was a therapeutic target in neuroblastoma.
[Cell Death & Disease] |
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| Beneficial effects were observed with rapamycin treatment as it decreased the gliotic response and prevented the development of newly formed blood vessels.
[Frontiers in Cell and Developmental Biology] |
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| The authors suggested that lncRNA RP5-998N21.4 was a critical regulator of immune defense, providing etiological and therapeutic implications for schizophrenia.
[npj Schizophrenia] |
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| Nine compounds demonstrated desirable glioblastoma cell toxicity in cell culture, and two of them, HR51, and HR59, demonstrated significantly improved capability of crossing the model blood–brain-barrier composed of endothelial cells, astrocytes and pericytes.
[Scientific Reports] |
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| Researchers established a library of secondly metabolites produced in microorganisms to investigate the potential effect of microorganisms on the production of amyloid β, one of the most representative pathogens of Alzheimer’s disease.
[Scientific Reports] |
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| The authors review evidence showing that brain inflammation and activation of cellular stress response mechanisms comprise molecular underpinnings of impaired brain insulin signaling in Alzheimer’s disease (AD) and integrate impaired insulin signaling with AD pathology.
[Nature Reviews Neuroscience] |
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| Investigators describe in detail the damage-associated molecular patterns that induce or aggravate neuroinflammation in neurodegenerative diseases including mitochondrial DNA, mitochondrial unfolded protein response, mitochondrial reactive oxygen species, and adenosine triphosphate.
[Acta Pharmacologica Sinica] |
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| Scientists provide recent findings and insights about miRNAs’ angioregulatory role and exosomal miRNAs in glioblastoma.
[Biomedicine & Pharmacotherapy] |
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| LEXEO Therapeutics announced positive initial expression and biomarker data from the low-dose cohort of its ongoing Phase I/II clinical trial of LX1001, an adeno-associated virus (AAV)-based investigational gene therapy.
[LEXEO Therapeutics] |
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| March 20 – March 25 |
Vienna, Austria |
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| | University of Lausanne – Lausanne, Switzerland |
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| | University Hospital Bonn – Bonn, Germany |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | NC State University – Raleigh, North Carolina, United States |
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