 | | Vol. 16.09 – 9 March, 2022 |
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| Scientists reported that at 24 hours after ischemia, microglia released brain-derived neurotrophic factor to downregulate glutamatergic and GABAergic synapses within the peri-infarct area.
[Science Advances] |
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| | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that, in mouse oligodendrocyte progenitor cells, nuclear entry of sirtuin 2 was impaired and NAD+ levels were reduced during aging.
[Nature Communications] |
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| Researchers showed that proline-arginine poly-dipeptides generated from C9orf72 repeat expansions increased the intrinsic excitability in pyramidal neurons of the motor cortex but not in the principal neurons of the visual cortex, somatosensory cortex, or hippocampus.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Genetic lineage tracing and time-course analyses revealed that DLX2 enabled astrocytes to rapidly become ASCL1+ neural progenitor cells, which gave rise to neurons, astrocytes, and oligodendrocytes in the adult mouse striatum.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists identified C-type lectin Reg3γ as a nociceptor-enriched hormone that protected the host from endotoxic death.
[Cell Reports] |
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| RNA-seq analyses comparing wild-type antennae to those ectopically expressing AgOR2 in olfactory receptor neurons indicated that nearly all AgOR transcripts were significantly downregulated, except for AgOR2.
[Cell Reports] |
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| Analysis of RNA sequencing and qRT-PCR revealed that miR-3189 increased and GLUT3 decreased by histone deacetylase 2 (HDAC2) knockdown.
[Journal of Experimental & Clinical Cancer Research] |
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| Researchers described an approach to derive microglia from human induced pluripotent stem cells (iPSCs) and integrated them into iPSC-derived midbrain organoids.
[Glia] |
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| Data showed that thrombospondin-1 (Tsp-1) downregulation aggravated UV irradiation-induced DNA damage in 661 W cells and cone photoreceptor cells.
[Cell and Tissue Research] |
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| Over the past decade, the number of genes associated with ALS has risen dramatically and, with each new genetic variant, there is a drive to develop associated animal models. The authors summarize the full spectrum of ALS rodent models developed to date.
[Nature Reviews Neuroscience] |
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| Investigators review the association between iron deposition, glial activation, and neuronal death, and discuss whether and how ferroptosis affects α-synuclein aggregation and dopaminergic neuron loss.
[Trends in Molecular Medicine] |
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| Six Canadian research teams have been awarded funding for the implementation and/or continuation of sex and gender considerations in research on aging, neurodegeneration, and stroke.
[Brain Canada Foundation] |
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| Cellevolve Bio and Seattle Children’s Therapeutics announced a collaboration aimed at developing and commercializing a suite of novel multiplex chimeric antigen receptors for the treatment of pediatric CNS malignancies.
[Cellevolve Bio] |
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| April 3 – 6, 2022
Warwick, England, United Kingdom |
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| | Queen Mary University of London – London, England, United Kingdom |
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| | University of Pennsylvania – Philadelphia, PA, United States |
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| | Baylor College of Medicine – Houston, TX, United States |
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| | University of Oslo – Oslo, Norway |
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| | University Hospital Bonn – Bonn, Germany |
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