Neural Cell News Volume 16.10 | Mar 16 2022

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    2022-03-16 | NCN 16.10


    Neural Cell News by STEMCELL Technologies
    Vol. 16.10 – 16 March, 2022
    TOP STORY

    Excessive Release of Inorganic Phosphate by ALS/FTD Astrocytes Causes Non-Cell-Autonomous Toxicity to Motoneurons

    Researchers reported that mouse and patient induced pluripotent stem cells-derived astrocytes with diverse ALS/frontotemporal dementia (FTD)-linked mutations (SOD1, TARDBP, and C9ORF72) displayed elevated levels of intracellular inorganic polyphosphate.
    [Neuron]

    AbstractGraphical Abstract
    Explore Antibodies for Epithelial Cell Markers
    PUBLICATIONSRanked by the impact factor of the journal

    Localized Astrogenesis Regulates Gyrification of the Cerebral Cortex

    Researchers showed that localized astrogenesis played an important role in gyri formation in the gyrencephalic cerebral cortex.
    [Science Advances]

    Full Article

    A Comprehensive Temporal Patterning Gene Network in Drosophila Medulla Neuroblasts Revealed by Single-Cell RNA Sequencing

    The authors used single-cell RNA sequencing of Drosophila medulla neuroblasts of all ages and identified a list of previously unknown temporal transcription factors, and experimentally characterized their roles in temporal patterning and neuronal specification.
    [Nature Communications]

    Full Article

    Microglia Regulate Chandelier Cell Axo-Axonic Synaptogenesis

    Scientists identifed a synaptogenic/growth-promoting role for microglia in regulating pyramidal neuron axon initial segment (AIS) synapse formation by chandelier cells, a unique interneuron subtype whose axonal terminals, called cartridges, selectively targeted the AIS.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full ArticlePress Release

    Dopamine D2 Receptor Signaling in the Brain Modulates Circadian Liver Metabolomic Profiles

    Investigators showed that dopamine D2 receptors in striatal medium spiny neurons played a key role in regulating diurnal liver metabolic activities.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Neuron-Epidermal Attachment Protects Hyper-Fragile Axons from Mechanical Strain

    The authors revealed a neuroprotective function of neuron-epidermal attachment in Caenorhabditis elegans.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Human Cerebral Organoids Reveal Progenitor Pathology in EML1-Linked Cortical Malformation

    Researchers used cerebral organoids derived from patients and genome-edited-induced pluripotent stem cells to address pathophysiological changes associated with a complex malformation of human cortical development caused by mutations in the echinoderm microtubule-associated protein-like 1 (EML1) gene.
    [EMBO Reports]

    Full ArticleGraphical Abstract

    Targeted Exon Skipping of NF1 Exon 17 as a Therapeutic for Neurofibromatosis Type I

    Initial in silico analysis predicted exons that could be skipped with minimal loss of neurofibromin function, which was confirmed with in vitro assessments utilizing an neurofibromatosis type 1 (Nf1) complementary DNA-based functional screening system.
    [Molecular Therapy-Nucleic Acids]

    AbstractFull ArticleGraphical Abstract

    Tissue-Engineered In Vitro Modeling of the Impact of Schwann Cells in Amyotrophic Lateral Sclerosis

    Scientists investigated whether Schwann cells could be involved in the disease pathogenesis of ALS, and developed a tissue-engineered 3D in vitro model that combined motor neurons cocultured with astrocytes.
    [Biotechnology and Bioengineering]

    Abstract
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    REVIEWS

    Advances in Local Therapy for Glioblastoma — Taking the Fight to the Tumour

    Investigators discuss the latest developments in local therapy for glioblastoma, focusing on recent preclinical and clinical trials.
    [Nature Reviews Neurology]

    Abstract

    Reactive Gliosis in Alzheimer’s Disease: A Crucial Role for Cognitive Impairment and Memory Loss

    The authors review the mechanisms by which a reactive gliosis can induce or contribute to the development and progression of Alzheimer’s disease.
    [Metabolic Brain Disease]

    Abstract

    INDUSTRY AND POLICY NEWS

    Ivy Brain Tumor Center Opens New Clinical Trial for Patients with Recurrent Grade IV Gliomas

    The Ivy Brain Tumor Center at Barrow Neurological Institute announced the opening of a new Phase 0/Ib clinical trial to evaluate AZD1390, an Ataxia telangiectasia mutant kinase inhibitor being developed by AstraZeneca, in patients with recurrent grade IV gliomas.
    [The Ivy Brain Tumor Center]

    Press Release

    Long-Term Phase III Data Show ADUHELM® Continues to Reduce Underlying Pathologies of Alzheimer’s Disease in Patients Treated for More Than Two Years

    Biogen, Inc. announced new data showing that after nearly two and a half years of treatment with ADUHELM® patients in the long-term extension phase of the Phase III trials continued to experience significant reductions in two key Alzheimer’s disease pathologies, amyloid-beta plaques and plasma p-tau181.
    [Biogen Inc.]

    Press Release
    FEATURED EVENT

    EMBO: Microbial Infections and Human Cancer

    April 6 – 9, 2022
    Heidelberg, Germany

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    JOB OPPORTUNITIES

    Professorship – Dementias and Neurodegenerative Diseases

    University of Bern – Bern, Switzerland

    Postdoctoral Associate – Neuroscience/Genetics

    Baylor College of Medicine – Houston, TX, United States

    Postdoctoral Research Associate – Neural Stem Cells

    Queen Mary University of London – London, England, United Kingdom

    Postdoctoral Fellow – Biomedical Imaging

    University of Pennsylvania – Philadelphia, PA, United States

    Postdoctoral Associate – Molecular Neuroscience and Disease

    Baylor College of Medicine – Houston, TX, United States

    > See All Jobs

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