Neural Cell News Volume 16.12 | Mar 30 2022

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    2022-03-30 | NCN 16.12


    Neural Cell News by STEMCELL Technologies
    Vol. 16.12 – 30 March, 2022
    TOP STORY

    Human and Mouse Trigeminal Ganglia Cell Atlas Implicates Multiple Cell Types in Migraine

    Investigators developed a cell atlas in which human and mouse trigeminal ganglia were transcriptionally and epigenomically profiled at single-cell resolution.
    [Neuron]

    AbstractGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Blockage of MLKL Prevents Myelin Damage in Experimental Diabetic Neuropathy

    The authors showed that targeting mixed lineage kinase domain-like protein (MLKL), a protein critical in necroptosis, using Schwann cell-specific genetic knockout, S441A single–amino acid knockin mutation or pharmacological inhibition all blocked myelin sheath decompaction.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Oleic Acid Is an Endogenous Ligand of TLX/NR2E1 That Triggers Hippocampal Neurogenesis

    Scientists showed that oleic acid was critical for neural stem cell survival and demonstrated that it bound to the nuclear receptor TLX to convert it from a transcriptional repressor to a transcriptional activator of cell-cycle and neurogenesis genes.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full ArticlePress Release

    FOSL1 Promotes Proneural-to-Mesenchymal Transition of Glioblastoma Stem Cells via UBC9/CYLD/NF-κB Axis

    Researchers reported that FOSL1, a component of activator protein 1 transcription factor complexes, was a key player in regulating proneural-to-mesenchymal transition.
    [Molecular Therapy]

    AbstractGraphical Abstract

    Palmitoylation Couples the Kinases DLK and JNK3 to Facilitate Prodegenerative Axon-to-Soma Signaling

    Investigators identified two ways through which dual leucine-zipper kinase (DLK) was coupled to the neural-specific isoform c-Jun N-terminal kinase 3 (JNK3) to control prodegenerative signaling.
    [Science Signaling]

    Abstract

    LncRNA TUG1 Compromised Neuronal Mitophagy in Cerebral Ischemia/Reperfusion Injury by Targeting Sirtuin 1

    Upregulation of the taurine-upregulated gene 1 (TUG1) level and downregulation of the mitophagy were observed in both middle cerebral artery occlusion/reperfusion-treated rats and oxygen-glucose deprivation and reoxygenation-treated cells.
    [Cell Biology and Toxicology]

    AbstractGraphical Abstract

    Human Forebrain Organoids Reveal Connections between Valproic Acid Exposure and Autism Risk

    Scientists used human forebrain organoids, in vitro derived 3D cell cultures that recapitulated key human brain developmental features.
    [Translational Psychiatry]

    Full Article

    Inhibitory Effects of Temozolomide on Glioma Cells Is Sensitized by RSL3-Induced Ferroptosis but Negatively Correlated with Expression of Ferritin Heavy Chain 1 and Ferritin Light Chain

    Investigators treated glioblastoma cells with RSL3, a ferroptosis inducer, in vitro cell lines and in vivo subcutaneous and orthotopic animal models.
    [Laboratory Investigation]

    Abstract

    Activated Endothelial Cells Induce a Distinct Type of Astrocytic Reactivity

    The authors showed that endothelial-induced astrocytes had upregulated expression of A1 astrocytic genes and exhibited a distinctive extracellular matrix remodeling profile.
    [Communications Biology]

    Full Article

    Infection of Human Microglial Cell Line CHME-3 to Study Neuropathogenesis of Chikungunya Virus

    Researchers characterized the progression of chikungunya virus (CHIKV) infection in the human microglial cell line CHME-3. The susceptibility of these cells to CHIKV and the viral replication kinetics were assessed during the early and late phases of infection.
    [Journal of Neurovirology]

    Abstract
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    REVIEWS

    Insulin Action in the Brain: Cell Types, Circuits, and Diseases

    The authors summarize the key roles of insulin action in the brain and how this involves different brain cell types. Disordered brain insulin signaling can also contribute to neuropsychiatric diseases, affecting brain circuits involved in mood and cognition.
    [Trends in Neurosciences]

    Abstract

    The Contribution of Altered Neuronal Autophagy to Neurodegeneration

    Investigators summarize the latest studies on the role that altered neuronal autophagy plays in brain health and these pathological conditions, and how this knowledge can be leveraged for the development of novel therapeutics against them.
    [Pharmacology & Therapeutics]

    Full Article
    INDUSTRY AND POLICY NEWS

    FDA Clears ReAlta Life Science’s Phase II STAR Trial of RLS-0071 in Neonates with Hypoxic-Ischemic Encephalopathy

    ReAlta Life Sciences, Inc. announced FDA clearance of an investigational new drug application for a Phase II clinical trial of RLS-0071 in neonates with hypoxic-ischemic encephalopathy.
    [ReAlta Life Sciences, Inc.]

    Press Release

    Prothena Announces FDA Clearance of IND for PRX012, a Subcutaneous Anti-Amyloid Beta Antibody Under Investigation for the Treatment of Alzheimer’s Disease

    Prothena Corporation plc announced that the FDA has cleared the investigational new drug application for PRX012, a potential best-in-class anti-amyloid beta antibody in development for the treatment of Alzheimer’s disease.
    [Prothena Corporation PLC]

    Press Release
    FEATURED EVENT

    AACR Annual Meeting 2022

    April 8, 2022 – April 13, 2022
    New Orleans, Louisiana, United States

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    JOB OPPORTUNITIES

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    Flanders Institute for Biotechnology – Ghent, Belgium

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    Indiana University School of Medicine – Indianapolis, Indiana, United States

    Senior Research Scientist – Neurology

    UT Southwestern – Dallas, Texas, United States

    Canadian Excellence Research Chair – Metabolism and the Brain

    McGill University – Montreal, Quebec, Canada

    Principal Investigator Positions – Functional Neurobiology

    Flanders Institute for Biotechnology – Antwerp, Belgium

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