 | | Vol. 16.13 – 6 April, 2022 |
| |
|
|
| Scientists found that a longer duration of epilepsy was associated with a sharp decline in neuronal production and persistent numbers in astrogenesis.
[Nature Neuroscience] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Using single-neuron reconstruction of 6,357 mouse prefrontal cortex (PFC) projection neurons, investigators identified 64 projectome-defined subtypes. Each of four previously known major cortico-cortical subnetworks was targeted by a distinct group of PFC subtypes defined by their first-order axon collaterals.
[Nature Neuroscience] |
|
|
|
| To improve understanding of transcriptomic heterogeneity in glia during Alzheimer’s disease (AD), the authors used single-nuclei RNA sequencing to characterize astrocytes and oligodendrocytes from apolipoprotein Ɛ2/3 human AD and age- and genotype-matched non-symptomatic brains.
[Neuron] |
|
|
|
| Researchers identified cylindromatosis (CYLD) as a negative regulator of dopamine neuron survival, and inhibition of CYLD could potentially be beneficial in Parkinson’s disease by lowering PARIS levels and promoting mitochondrial biogenesis.
[Science Advances] |
|
|
|
| Scientists combined stem cell culturing with transplantation techniques to determine disease-specific properties inherent to autism spectrum disorder astrocytes.
[Molecular Psychiatry] |
|
|
|
| Employing human cerebral organoids, the authors found that chromodomain helicase DNA-binding 8 (CHD8) haploinsufficiency disrupted neurodevelopmental trajectories with an accelerated and delayed generation of, respectively, inhibitory and excitatory neurons.
[Cell Reports] |
|
|
|
| Researchers reported on the novel mechanism whereby overexpressed class I histone deacetylases (HDACs) increase the resistance of glioblastoma cells to the SN1 methylating agent temozolomide.
[Cell Death & Disease] |
|
|
|
| Using RNA-seq, investigators directly compared TAR DNA-binding protein 43 (TDP-43)-mediated RNA processing in muscle and neuronal mouse cells.
[Communications Biology] |
|
|
|
| RNA TCF25 (circTCF25) was predominantly located in the cytoplasm; the combination of microRNA-206 and circTCF25 reversed the effects of knockdown of circTCF25 on the proliferation, migration, invasion, and tumorigenesis of glioma cells.
[Molecular Carcinogenesis] |
|
|
|
| Scientists adapted a previously established brain tissue model to fresh patient tumor cells with the goal of establishing 3D in vitro culture conditions for each tumor type.
[Translational Oncology] |
|
|
|
|
| The authors summarize current knowledge on the impact of astrocyte and microglia activity on behavioral outcomes, with a specific focus on brain areas relevant to higher cognitive control, reward-seeking, and circadian regulation.
[Neuroscience and Biobehavioral Reviews] |
|
|
|
| Investigators describe recent approaches that specifically increase synaptic resilience, as loss of synapses is considered to be the first change in the brains of Alzheimer’s patients.
[Seminars in Cell & Developmental Biology] |
|
|
|
|
| Takeda and the New York Academy of Sciences announced the winners of the fourth Innovators in Science Award for their excellence in, and commitment to, innovative science that has significantly advanced the field of research in gastroenterology.
[Takeda Pharmaceutical Company Limited] |
|
|
|
| The MS Society of Canada announced a nearly $1.35 million investment from Biogen Canada Inc., Hoffmann-La Roche Limited, and Brain Canada Foundation towards a new sub-cohort of the Canadian Prospective Cohort Study to Understand Progression in MS.
[Multiple Sclerosis Society of Canada] |
|
|
|
|
|
|
|
| | University of Pittsburgh School of Medicine – Pittsburgh, Pennsylvania, United States |
|
|
|
| | University of British Columbia – Vancouver, British Columbia, Canada |
|
|
|
| | RIKEN Center for Brain Science – Tokyo, Japan |
|
|
|
| | Flanders Institute for Biotechnology – Ghent, Belgium |
|
|
|
| | Indiana University School of Medicine – Indianapolis, Indiana, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
