 | | Vol. 16.14 – 13 April, 2022 |
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| Scientists reported that the orphan G protein–coupled receptor 177 (GPR177) in A-fiber neurons drove diabetic neuropathic pain via WNT5a-mediated activation of transient receptor potential vanilloid receptor-1 (TRPV1) ion channel.
[Science Translational Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors demonstrated that the entire miR-10b-hosting HOXD locus was activated in glioma via the cis-acting mechanism involving 3D chromatin reorganization and CTCF-cohesin-mediated looping.
[Molecular Cell] |
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| Researchers screened a library of drugs either FDA-approved or in clinical trial using a library of patient-derived H3K27M-mutant diffuse midline glioma cell lines with cell viability as the outcome.
[Neuro-Oncology] |
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| Scientists used single-cell RNA-sequencing to analyze new and recurrent glioblastoma, and the nearby subventricular zone. They found four glioblastoma neural lineages were present in new and recurrent glioblastoma with an enrichment of the cancer mesenchymal lineage, immune cells, and reactive astrocytes in early recurrences.
[Neuro-Oncology] |
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| Investigators performed a fluorescent cell sorting based genome-wide CRISPR-Cas9 screen in alpha-synuclein (αS) biosensors. αS and TDP-43 seeding activity under varied conditions was assessed using FRET/Flow biosensor cells or immunofluorescence for phosphorylated αS or TDP-43 in primary cultured neurons.
[Molecular Neurodegeneration] |
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| The authors studied the importance of CCL18, a cytokine expressed in human but not in rodent glioma-associated microglia/macrophages, as a modulator of glioma growth.
[Cell Reports] |
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| Plumbagin showed higher blood-brain barrier penetration ability than that of lapachol and shikonin and elicited significant growth inhibitory effects in vitro and in vivo.
[British Journal of Cancer] |
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| Scientists observed that disrupting glioblastoma hyaluronic acid (HA) synthesis or blocking HA binding to its receptor CD44 on macrophages increased the proportion of M1 macrophages by upregulating SIRPα in macrophages,
[Cell Death Discovery] |
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| Researchers found that the expression of TFCP2 was upregulated in glioma and that TFCP2 promoted glioma cell growth and sphere formation.
[Experimental Cell Research] |
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| Individuals with HIV-associated amyotrophic lateral sclerosis show a remarkable response to antiretroviral therapy; however, antiretroviral trials in ALS down-regulate HML-2 without ameliorating the disease.
[Neurotherapeutics] |
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| The authors summarize the current knowledge on the possible microglial states during development, homeostasis, and perturbation.
[Immunology Letters] |
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| POXEL SA announced that the FDA has granted Fast Track Designation to PXL770 for the treatment of patients with adrenomyeloneuropathy, the most common form of X-linked adrenoleukodystrophy.
[Poxel SA] |
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| The Cancer Prevention and Research Institute of Texas awarded a four-year, $1.34 million grant to C. Patrick Reynolds, director for the School of Medicine Cancer Center at the Texas Tech University Health Sciences Center, for his investigation into updating the clinical risk stratification scale for neuroblastoma and rhabdomyosarcoma.
[Texas Tech University (EurekAlert!)] |
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| June 12 – 17, 2022
New London, New Hampshire, United States |
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| | | | | Harvard University – Cambridge, Massachusetts, United States |
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| | | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | | University of Pittsburgh School of Medicine – Pittsburgh, Pennsylvania, United States |
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| | | University of British Columbia – Vancouver, British Columbia, Canada |
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| | | RIKEN Center for Brain Science – Tokyo, Japan |
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