 | | Vol. 16.15 – 20 April, 2022 |
| |
|
|
| Researchers analyzed single-cell whole-genome sequencing data from 319 neurons from the prefrontal cortex and hippocampus of individuals with Alzheimer’s disease and neurotypical control individuals.
[Nature] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Investigators revealed brain-wide cellular reactions to type I interferon, an innate immune cytokine aberrantly elicited by amyloid β plaques, and examined their role in cognition and neuropathology relevant to Alzheimer’s disease in a murine amyloidosis model.
[Immunity] |
|
|
|
| Scientists reported that the dormancy of quiescent neural stem cells was a therapeutic target for controlling the development of autism spectrum disorder phenotypes driven by Shank3 deficiency.
[Molecular Psychiatry] |
|
|
|
| The authors reported that PTEN in primary sensory neurons was involved in processing itch and thermal information in adult mice.
[Cell Reports] |
|
|
|
| Investigators revealed the regulatory mechanism of the SUR1 subunit and the role of ATP-sensitive potassium (KATP) channels in the progression of dopaminergic neuron degeneration.
[Aging Cell] |
|
|
|
| The authors showed that NAD-dependent protein deacetylase sirtuin 2 (SIRT2) knockout was able to effectively ameliorate anomalous behavioral phenotypes in transgenic mouse models of Parkinson’s disease.
[npj Parkinson’s Disease] |
|
|
|
| Scientists investigated the role of astrocytic Na+/H+ exchanger 1 in regulating reactive astrocyte lipocalin-2 (LCN2) secretion and neurodegeneration after stroke.
[Cell Death & Disease] |
|
|
|
| In vitro studies using primary mouse cortical neurons showed that non-p-tau accumulated perinuclearly together with the tubulin after double-strand break induction with etoposide.
[Communications Biology] |
|
|
|
| In glioma cells, depletion of guanylate-binding protein 2 (GBP2) impaired proliferation and migration, whereas overexpression of GBP2 enhanced proliferation and migration.
[Cell Death Discovery] |
|
|
|
| Researchers evaluated the role of ubiquitin-specific protease 32 (USP32) in glioblastoma (GBM) progression and provided a potential target for GBM treatment. The clinical significance of USP32 was investigated using Gene Expression Omnibus databases.
[Scientific Reports] |
|
|
|
|
| Investigators discuss recent advances in how neurons maintain a healthy pool of axonal mitochondria, as well as potential therapeutic strategies that target bioenergetic restoration to power neuronal survival, function, and regeneration.
[Neuron] |
|
|
|
| The authors address the underlying mechanisms behind synaptic loss and dysfunction in Alzheimer’s disease and discuss potential strategies that target the synapse.
[Molecular Psychiatry] |
|
|
|
|
| Neuraly announced the completion of patient enrollment in its Phase II study of NLY01 for Parkinson’s disease.
[Neuraly, Inc. (Business Wire)] |
|
|
|
| Neuropore Therapies, Inc. announced that it received a $4.8M grant from The Michael J. Fox Foundation for Parkinson’s Research. The grant will be used to support the preclinical and clinical development of a novel brain-penetrating small molecule Toll-Like receptor 2 (TLR2) antagonist.
[Neuropore Therapies, Inc.] |
|
|
|
|
| May 22 – 27, 2022
Lucca, Italy |
|
|
|
|
|
| | Max Delbrück Center for Molecular Medicine – Berlin, Germany |
|
|
|
| | University of California, San Diego – La Jolla, California, United States |
|
|
|
| | University of California Los Angeles – Los Angeles, California, United States |
|
|
|
| | University of Pittsburgh School of Medicine – Pittsburgh, Pennsylvania, United States |
|
|
|
| | University of British Columbia – Vancouver, British Columbia, Canada |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
