Neural Cell News Volume 16.16 | Apr 27 2022

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    2022-04-27 | NCN 16.16


    Neural Cell News by STEMCELL Technologies
    Vol. 16.16 – 27 April, 2022
    TOP STORY

    Cell-Lineage Controlled Epigenetic Regulation in Glioblastoma Stem Cells Determines Functionally Distinct Subgroups and Predicts Patient Survival

    Scientists analyzed and compared the chromatin-accessibility landscape of nine mouse glioblastoma stem cell cultures of three defined origins and 60 patient-derived glioblastoma stem cell cultures.
    [Nature Communications]

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    PUBLICATIONSRanked by the impact factor of the journal

    Increased Apoptotic Sensitivity of Glioblastoma Enables Therapeutic Targeting by BH3-Mimetics

    The authors investigated the therapeutic potential of targeting anti-apoptotic BCL-2 proteins in glioblastoma.
    [Cell Death & Differentiation]

    Full Article

    Glial-Secreted Netrins Regulate Robo1/Rac1-Cdc42 Signaling Threshold Levels during Drosophila Asymmetric Neural Stem/Progenitor Cell Division

    Investigators showed that the extrinsic axon guidance cues Netrins, secreted by a glial niche surrounding larval brain neural stem cell lineages, regulated neuroblast asymmetric stem cell division.
    [Current Biology]

    AbstractGraphical Abstract

    CBX3 Accelerates the Malignant Progression of Glioblastoma Multiforme by Stabilizing EGFR Expression

    Researchers reported the identification of CBX3 as a potential therapeutic target for glioblastoma multiforme (GBM) and found that, CBX3 was significantly upregulated in GBM and reduced patient survival.
    [Oncogene]

    Abstract

    Molecular Mechanism of m6A Methylation of CircDLC1 Mediated by RNA Methyltransferase METTL3 in the Malignant Proliferation of Glioma Cells

    Scientists investigated the function of circular RNA DLC1 (circDLC1) in the malignant proliferation of glioma cells.
    [Cell Death Discovery]

    Full Article

    Glioma Facilitates the Epileptic and Tumor-Suppressive Gene Expressions in the Surrounding Region

    Investigators developed a rat model of glioma and characterized it at the cellular and molecular levels.
    [Scientific Reports]

    Full Article

    Differential Expression of an Endogenous Retroviral Element [HERV-K(HML-6)] Is Associated with Reduced Survival in Glioblastoma Patients

    The authors utilized a tailored bioinformatic pipeline, characterized and validated the glioma retrotranscriptome, and correlated human endogenous retroviruses (HERV) expression with locus-specific epigenetic modifications.
    [Scientific Reports]

    Full Article

    Elevation of Phospholipase C-β1 Expression by Amyloid-β Facilitates Calcium Overload in Neuronal Cells

    Scientists focused on the cellular function of phospholipase C-β1, which regulated calcium signaling by mediating hydrolysis of phosphatidylinositol 4,5-bisphosphate through G-protein coupled receptor pathways.
    [Brain Research]

    Full ArticleGraphical Abstract

    The Neuroprotective Effects of Paeoniflorin against MPP+-Induced Damage to Dopaminergic Neurons via the Akt/Nrf2/GPX4 Pathway

    Researchers indicated that the neuroprotective effect of paeoniflorin could be partially blocked by ML385, a nuclear factor erythroid-2-related factor 2 (Nrf2) inhibitor, and LY29400 an Akt inhibitor.
    [Journal of Chemical Neuroanatomy]

    Abstract
    Virtual Poster Presentation: CRISPR-Cas9 Gene Editing of Cerebral Organoids to Model Microcephaly
    REVIEWS

    Epitranscriptomic Dynamics in Brain Development and Disease

    Investigators review the current knowledge surrounding the role of the RNA modifications N6-methyladenosine, 5-methylcytidine, pseudouridine, A-to-I RNA editing, 2′O-methylation, and their associated machinery, in brain development and human diseases.
    [Molecular Psychiatry]

    Abstract

    Similarities and Differences between Nigral and Enteric Dopaminergic Neurons Unravel Distinctive Involvement in Parkinson’s Disease

    The authors highlight the distinctive and shared factors and properties that control the evolution of nigral and enteric dopaminergic neurons from neuronal precursors to aging neurons.
    [npj Parkinson’s Disease]

    Full Article
    INDUSTRY AND POLICY NEWS

    Prothena Receives FDA Fast Track Designation for PRX012, a Next-Generation Anti-Amyloid Beta Antibody Under Investigation for the Treatment of Alzheimer’s Disease

    Prothena Corporation plc announced that the US FDA has granted Fast Track designation for PRX012, a potential best-in-class anti-amyloid beta antibody therapy currently being investigated in Phase I clinical study for the treatment of Alzheimer’s disease.
    [Prothena Corporation plc]

    Press Release

    Gift from Phil and Penny Knight Launches Scientific Endeavor to Combat Neurodegeneration

    Based at the Wu Tsai Neurosciences Institute, a new scientific endeavor tackling neurodegeneration is being launched by a $75 million gift from Nike founder Philip H. Knight, MBA ’62, and his wife, Penny.
    [Stanford University]

    Press Release
    FEATURED EVENT

    Brain Tumor Meeting 2022

    May 19 – 20, 2022
    Berlin, Germany

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Assistant – Protein Phosphorylation and Ubiquitylation

    University of Dundee – Dundee, Scotland, United Kingdom

    Faculty Positions – Neuroscience

    The Hong Kong University of Science and Technology – Guangzhou, China

    Postdoctoral Fellow – Leptin Signaling Lab

    Pennington Biomedical Research Center – Baton Rouge, Louisiana, United States

    Postdoctoral positions – Synaptic Transmission in Energy Homeostasis

    Max Planck Institute for Metabolism Research – Cologne, Germany

    Postdoctoral Fellow – Neurogenomics Lab

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    > See All Jobs

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