| Vol. 16.16 – 27 April, 2022 |
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| Scientists analyzed and compared the chromatin-accessibility landscape of nine mouse glioblastoma stem cell cultures of three defined origins and 60 patient-derived glioblastoma stem cell cultures. [Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors investigated the therapeutic potential of targeting anti-apoptotic BCL-2 proteins in glioblastoma. [Cell Death & Differentiation] |
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| Investigators showed that the extrinsic axon guidance cues Netrins, secreted by a glial niche surrounding larval brain neural stem cell lineages, regulated neuroblast asymmetric stem cell division. [Current Biology] |
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| Researchers reported the identification of CBX3 as a potential therapeutic target for glioblastoma multiforme (GBM) and found that, CBX3 was significantly upregulated in GBM and reduced patient survival. [Oncogene] |
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| Scientists investigated the function of circular RNA DLC1 (circDLC1) in the malignant proliferation of glioma cells. [Cell Death Discovery] |
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| Investigators developed a rat model of glioma and characterized it at the cellular and molecular levels. [Scientific Reports] |
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| The authors utilized a tailored bioinformatic pipeline, characterized and validated the glioma retrotranscriptome, and correlated human endogenous retroviruses (HERV) expression with locus-specific epigenetic modifications. [Scientific Reports] |
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| Scientists focused on the cellular function of phospholipase C-β1, which regulated calcium signaling by mediating hydrolysis of phosphatidylinositol 4,5-bisphosphate through G-protein coupled receptor pathways. [Brain Research] |
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| Researchers indicated that the neuroprotective effect of paeoniflorin could be partially blocked by ML385, a nuclear factor erythroid-2-related factor 2 (Nrf2) inhibitor, and LY29400 an Akt inhibitor. [Journal of Chemical Neuroanatomy] |
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| Investigators review the current knowledge surrounding the role of the RNA modifications N6-methyladenosine, 5-methylcytidine, pseudouridine, A-to-I RNA editing, 2′O-methylation, and their associated machinery, in brain development and human diseases. [Molecular Psychiatry] |
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| The authors highlight the distinctive and shared factors and properties that control the evolution of nigral and enteric dopaminergic neurons from neuronal precursors to aging neurons. [npj Parkinson’s Disease] |
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| Prothena Corporation plc announced that the US FDA has granted Fast Track designation for PRX012, a potential best-in-class anti-amyloid beta antibody therapy currently being investigated in Phase I clinical study for the treatment of Alzheimer’s disease. [Prothena Corporation plc] |
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| Based at the Wu Tsai Neurosciences Institute, a new scientific endeavor tackling neurodegeneration is being launched by a $75 million gift from Nike founder Philip H. Knight, MBA ’62, and his wife, Penny. [Stanford University] |
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| May 19 – 20, 2022 Berlin, Germany |
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| University of Dundee – Dundee, Scotland, United Kingdom |
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| The Hong Kong University of Science and Technology – Guangzhou, China |
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| Pennington Biomedical Research Center – Baton Rouge, Louisiana, United States |
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| Max Planck Institute for Metabolism Research – Cologne, Germany |
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| Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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