Neural Cell News Volume 16.19 | May 18 2022

    0
    28







    2022-05-18 | NCN 16.19


    Neural Cell News by STEMCELL Technologies
    Vol. 16.19 – 18 May, 2022
    TOP STORY

    Myotubularin-Related Phosphatase 5 Is a Critical Determinant of Autophagy in Neurons

    Scientists sampled nascent transcript synthesis and stabilities in fibroblasts, induced pluripotent stem cells (iPSCs), and iPSC-derived neurons, thereby uncovering neuron-specific stability of transcripts encoding myotubularin-related phosphatase 5.
    [Current Biology]

    Abstract
    Organoids: Experts Talk Standardization at Nature Research Round Table
    PUBLICATIONSRanked by the impact factor of the journal

    PLGA-Nano-Encapsulated Disulfiram Inhibits Hypoxia-Induced NFκB, Cancer Stem Cells and Targets Glioblastoma In Vitro and In Vivo

    The in vitro anti-glioblastoma (GBM) stem cell activity of disulfiram (DS) and in vivo anti-GBM efficacy of poly lactic-co-glycolic acid nanoparticle-encapsulated DS were examined.
    [Molecular Cancer Therapeutics]

    Abstract

    Neuron-Astrocyte Transmitophagy Is Altered in Alzheimer’s Disease

    The authors reported that the internalization of neuronal mitochondria was significantly increased in astrocytes isolated from Alzheimer’s disease mouse brains.
    [Neurobiology of Disease]

    Full ArticleGraphical Abstract

    Apolipoprotein C1 Promotes Glioblastoma Tumorigenesis by Reducing KEAP1/NRF2 and CBS-Regulated Ferroptosis

    Researchers investigated the role of apolipoprotein C1 (APOC1) in glioblastoma (GBM) tumorigenesis. Using in silico assays they showed that APOC1 was highly expressed in GBM tissues and its expression was closely related to GBM progression.
    [Acta Pharmacologica Sinica]

    Abstract

    Ammonia Induces Amyloidogenesis in Astrocytes by Promoting Amyloid Precursor Protein Translocation into the Endoplasmic Reticulum

    Investigators reported that hyperammonemia increased the amount of mature amyloid precursor protein in astrocytes, and promoted amyloid-beta production.
    [Journal of Biological Chemistry]

    Full Article

    MicroRNA-27a-3p Delivered by Extracellular Vesicles from Glioblastoma Cells Induces M2 Macrophage Polarization via the EZH1/KDM3A/CTGF Axis

    Isolated glioblastoma-extracellular vesicles (GBM-EVs) were co-cultured with macrophages. After co-culture under normoxia/hypoxia, the effect of EV-derived hsa-miR-27a-3p on GBM cell biological processes was analyzed.
    [Cell Death Discovery]

    Full Article

    High-Throughput Sequencing to Investigate lncRNA-circRNA-miRNA-mRNA Networks Underlying the Effects of Beta-Amyloid Peptide and Senescence on Astrocytes

    Researchers examined changes at the transcriptome level to explore the effects of amyloid-beta and senescence on astrocytes.
    [Frontiers in Genetics]

    Full Article

    F-Box Protein 11 Suppresses Cell Proliferation and Aerobic Glycolysis in Glioblastomas by Mediating the Ubiquitin Degradation of Cdc25A

    MTT and colony formation assays and enzyme-linked immunosorbent assay demonstrated that overexpression of F-box protein 11 suppressed proliferation and aerobic glycolysis and induced cell cycle arrest in U251-MG and A172 cells.
    [Journal of Neuropathology and Experimental Neurology]

    Abstract

    Neuroprotective Effect of Ginsenoside Re against Neurotoxin-Induced Parkinson’s Disease Models via Induction of Nrf2

    Investigators examined the neuroprotective effects of a panel of active components of ginseng and explored their molecular mechanisms of action in two rotenone‑induced models of Parkinson’s disease.
    [Molecular Medicine Reports]

    Abstract
    Request your free copy of the 'Frequencies of Cell Types in Human Peripheral Blood' Wallchart
    REVIEWS

    Glial-Neuron Crosstalk in Health and Disease: A Focus on Metabolism, Obesity, and Cognitive Impairment

    The authors focus on the metabolic crosstalk between the three major glial cell types, oligodendrocytes, astrocytes, and microglia, with neurons under physiological conditions.
    [Neurobiology of Disease]

    Full Article
    INDUSTRY AND POLICY NEWS

    C2N Diagnostics Introduces P-tau Multi-Analyte Assay for Research Use Only to Advance Alzheimer’s Disease and Brain Health Field

    C2N Diagnostics announced its latest innovative offering for enhancing care in brain health: a high-resolution mass spectrometry-based plasma tau multi-analyte assay for research use only.
    [C2N Diagnostics]

    Press Release

    Anonymous $11 Million Gift to Support and Expand Neurofibromatosis Research at UHN’s Krembil Brain Institute

    University Health Network (UHN) Foundation announced an anonymous gift of $11 million in support of neurofibromatosis research.
    [University Health Network (Newswise, Inc.)]

    Press Release

    FEATURED EVENT

    Cell Biology of the Neuron

    June 26 – July 1, 2022
    Waterville Valley, New Hampshire, United States

    > See All Events

    JOB OPPORTUNITIES

    Assistant Neuroscientist – Depression and Anxiety Disorders

    McLean Hospital – Boston, Massachusetts, United States

    Postdoctoral Position – Systems Neuroscience

    Max Planck Institute for Neurobiology of Behavior – Bonn, Germany

    Post Doctorate Research Fellow – Neuroscience

    Rush University – Chicago, Illinois, United States

    PhD Position – Systems Neuroscience

    Max Planck Institute for Neurobiology of Behavior – Bonn, Germany

    Postdoctoral Positions – Neurobiology and Informatics

    Leibniz-Forschungsinstitut für Molekulare Pharmakologie – Berlin, Germany

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Neural Cell News Twitter