| Vol. 16.19 – 18 May, 2022 |
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Myotubularin-Related Phosphatase 5 Is a Critical Determinant of Autophagy in Neurons | Scientists sampled nascent transcript synthesis and stabilities in fibroblasts, induced pluripotent stem cells (iPSCs), and iPSC-derived neurons, thereby uncovering neuron-specific stability of transcripts encoding myotubularin-related phosphatase 5. [Current Biology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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PLGA-Nano-Encapsulated Disulfiram Inhibits Hypoxia-Induced NFκB, Cancer Stem Cells and Targets Glioblastoma In Vitro and In Vivo | The in vitro anti-glioblastoma (GBM) stem cell activity of disulfiram (DS) and in vivo anti-GBM efficacy of poly lactic-co-glycolic acid nanoparticle-encapsulated DS were examined. [Molecular Cancer Therapeutics] |
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Neuron-Astrocyte Transmitophagy Is Altered in Alzheimer’s Disease | The authors reported that the internalization of neuronal mitochondria was significantly increased in astrocytes isolated from Alzheimer’s disease mouse brains. [Neurobiology of Disease] |
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Apolipoprotein C1 Promotes Glioblastoma Tumorigenesis by Reducing KEAP1/NRF2 and CBS-Regulated Ferroptosis | Researchers investigated the role of apolipoprotein C1 (APOC1) in glioblastoma (GBM) tumorigenesis. Using in silico assays they showed that APOC1 was highly expressed in GBM tissues and its expression was closely related to GBM progression. [Acta Pharmacologica Sinica] |
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Ammonia Induces Amyloidogenesis in Astrocytes by Promoting Amyloid Precursor Protein Translocation into the Endoplasmic Reticulum | Investigators reported that hyperammonemia increased the amount of mature amyloid precursor protein in astrocytes, and promoted amyloid-beta production. [Journal of Biological Chemistry] |
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MicroRNA-27a-3p Delivered by Extracellular Vesicles from Glioblastoma Cells Induces M2 Macrophage Polarization via the EZH1/KDM3A/CTGF Axis | Isolated glioblastoma-extracellular vesicles (GBM-EVs) were co-cultured with macrophages. After co-culture under normoxia/hypoxia, the effect of EV-derived hsa-miR-27a-3p on GBM cell biological processes was analyzed. [Cell Death Discovery] |
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High-Throughput Sequencing to Investigate lncRNA-circRNA-miRNA-mRNA Networks Underlying the Effects of Beta-Amyloid Peptide and Senescence on Astrocytes | Researchers examined changes at the transcriptome level to explore the effects of amyloid-beta and senescence on astrocytes. [Frontiers in Genetics] |
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F-Box Protein 11 Suppresses Cell Proliferation and Aerobic Glycolysis in Glioblastomas by Mediating the Ubiquitin Degradation of Cdc25A | MTT and colony formation assays and enzyme-linked immunosorbent assay demonstrated that overexpression of F-box protein 11 suppressed proliferation and aerobic glycolysis and induced cell cycle arrest in U251-MG and A172 cells. [Journal of Neuropathology and Experimental Neurology] |
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Neuroprotective Effect of Ginsenoside Re against Neurotoxin-Induced Parkinson’s Disease Models via Induction of Nrf2 | Investigators examined the neuroprotective effects of a panel of active components of ginseng and explored their molecular mechanisms of action in two rotenone‑induced models of Parkinson’s disease. [Molecular Medicine Reports] |
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Glial-Neuron Crosstalk in Health and Disease: A Focus on Metabolism, Obesity, and Cognitive Impairment | The authors focus on the metabolic crosstalk between the three major glial cell types, oligodendrocytes, astrocytes, and microglia, with neurons under physiological conditions. [Neurobiology of Disease] |
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C2N Diagnostics Introduces P-tau Multi-Analyte Assay for Research Use Only to Advance Alzheimer’s Disease and Brain Health Field | C2N Diagnostics announced its latest innovative offering for enhancing care in brain health: a high-resolution mass spectrometry-based plasma tau multi-analyte assay for research use only. [C2N Diagnostics] |
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Anonymous $11 Million Gift to Support and Expand Neurofibromatosis Research at UHN’s Krembil Brain Institute | University Health Network (UHN) Foundation announced an anonymous gift of $11 million in support of neurofibromatosis research. [University Health Network (Newswise, Inc.)] |
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| June 26 – July 1, 2022 Waterville Valley, New Hampshire, United States |
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| McLean Hospital – Boston, Massachusetts, United States |
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| Max Planck Institute for Neurobiology of Behavior – Bonn, Germany |
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| Rush University – Chicago, Illinois, United States |
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| Max Planck Institute for Neurobiology of Behavior – Bonn, Germany |
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| Leibniz-Forschungsinstitut für Molekulare Pharmakologie – Berlin, Germany |
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