Neural Cell News Volume 16.20 | May 25 2022

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    2022-05-25 | NCN 16.20


    Neural Cell News by STEMCELL Technologies
    Vol. 16.20 – 25 May, 2022
    TOP STORY

    Fate Mapping of Neural Stem Cell Niches Reveals Distinct Origins of Human Cortical Astrocytes

    By performing fate mapping in primary human tissue, investigators demonstrated that astrocytes derived from the ventricular and outer subventricular zone niches populated anatomically distinct layers.
    [Science]

    Abstract
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    Target Receptor Identification and Subsequent Treatment of Resected Brain Tumors with Encapsulated and Engineered Allogeneic Stem Cells

    Scientists showed the detection of cell surface death receptor target on CD146-enriched circulating tumor cells captured from the blood of mice bearing glioblastoma (GBM) and patients diagnosed with GBM.
    [Nature Communications]

    Full ArticlePress Release

    Single-Cell Transcriptomic Classification of Rabies-Infected Cortical Neurons

    The authors used single-nucleus RNA sequencing to survey the gene expression profiles of rabies-infected neurons and assessed their correspondence with established transcriptomic cell types.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Regionally Defined Proteomic Profiles of Human Cerebral Tissue and Organoids Reveal Conserved Molecular Modules of Neurodevelopment

    An analysis included recovery of precursor-enriched transcriptional regulatory proteins not found to be differentially expressed in previous transcriptomic datasets.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Disruption of β-Catenin-Mediated Negative Feedback Reinforces cAMP-Induced Neuronal Differentiation in Glioma Stem Cells

    Researchers demonstrated that cyclic AMP (cAMP) triggered neuronal differentiation and compromised the self-renewal capacity in glioma stem cells.
    [Cell Death & Disease]

    Full Article

    Circ-Pank1 Promotes Dopaminergic Neuron Neurodegeneration through Modulating miR-7a-5p/α-Syn Pathway in Parkinson’s Disease

    The authors found that circRNA derived from the pantothenate kinase 1 gene (circ-Pank1) could adsorb miR-7a-5p and upregulate the expression of α-synuclein (α-syn), which was a molecular hallmark closely related to Parkinson’s disease.
    [Cell Death & Disease]

    Full Article

    GSK3β Palmitoylation Mediated by ZDHHC4 Promotes Tumorigenicity of Glioblastoma Stem Cells in Temozolomide-Resistant Glioblastoma through the EZH2–STAT3 Axis

    Investigators found that glycogen synthase kinase 3β (GSK3β) was noted as a substrate for ZDHHC4-mediated palmitoylation at the Cys14 residue, which enhanced glioblastoma temozolomide resistance and glioblastoma stem cell self-renewal.
    [Oncogenesis]

    Full Article

    RNF216 Alleviates Radiation-Induced Apoptosis and DNA Damage Through Regulating Ubiquitination-Mediated Degradation of p53 in Glioblastoma

    Researchers compared the ring finger protein 216 (RNF216) expression in glioblastoma (GBM) tissues and normal peritumoral tissues and examined the effects of RNF216 overexpression/knockdown on tumorigenesis, radioresistance, and the p53 pathway in GBM.
    [Molecular Neurobiology]

    Abstract

    PM2.5 Exposure-Induced Ferroptosis in Neuronal Cells via Inhibiting ERK/CREB Pathway

    Scientists investigated if ferroptosis was involved in neurotoxicity post PM2.5 exposure and its underlying mechanism.
    [Environmental Toxicology]

    Abstract

    Tracing the Origins of Glioblastoma by Investigating the Role of Gliogenic and Related Neurogenic Genes/Signaling Pathways in GBM Development: A Systematic Review

    Researchers investigated the origins of glioblastoma (GBM), and it focused primarily on developmental gliogenic processes.
    [World Journal of Surgical Oncology]

    Full Article
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    REVIEWS

    Targeting Necroptosis as a Promising Therapy for Alzheimer’s Disease

    Investigators summarize the potential role of necroptosis in Alzheimer’s disease (AD) progression and the therapeutic capacity of targeting necroptosis for AD patients.
    [ACS Chemical Neuroscience]

    AbstractGraphical Abstract

    Tau Aggregation Inhibiting Peptides as Potential Therapeutics for Alzheimer Disease

    The authors review the current state of research in this promising field of Alzheimer’s disease therapy development.
    [Cellular and Molecular Neurobiology]

    Full ArticleGraphical Abstract

    INDUSTRY AND POLICY NEWS

    PharmaJet Partner, Institute for Molecular Medicine, Launches Clinical Trial for the First in Human Alzheimer’s DNA Vaccine

    PharmaJet® announced that its partner, the Institute for Molecular Medicine was awarded a $12 Million grant from the National Institute on Aging division of the National Institutes of Health.
    [PharmaJet®]

    Press Release

    Davos Alzheimer’s Collaborative Announces Early Detection Grants: $4.5 Million in Grant Funding Expands New Alzheimer’s Early Detection and Healthcare System Preparedness Efforts

    The Davos Alzheimer’s Collaborative announced the recipients of a grant program aiming for the early detection of cognitive symptoms. The early detection grants total $4.5 Million from 8 countries across North America, Asia, and Africa.
    [Davos Alzheimer’s Collaborative]

    Press Release
    FEATURED EVENT

    Mechanisms of Epilepsy and Neuronal Synchronization

    July 31 – August 5, 2022
    Castelldefels, Spain

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Associate – Molecular Neuroscience and Disease

    Baylor College of Medicine – Houston, Texas, United States

    Lecturer – Neuroscience

    The University of British Columbia – Vancouver, British Columbia, Canada

    Assistant Neuroscientist – Depression and Anxiety Disorders

    McLean Hospital – Boston, Massachusetts, United States

    Postdoctoral Position – Systems Neuroscience

    Max Planck Institute for Neurobiology of Behavior – Bonn, Germany

    Post Doctorate Research Fellow – Neuroscience

    Rush University – Chicago, Illinois, United States

    > See All Jobs

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