Neural Cell News Volume 16.24 | Jun 22 2022

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    2022-06-22 | NCN 16.24


    Neural Cell News by STEMCELL Technologies
    Vol. 16.24 – 22 June, 2022
    TOP STORY

    Spatial Centrosome Proteome of Human Neural Cells Uncovers Disease-Relevant Heterogeneity

    The authors used spatial proteomics to elucidate protein interaction networks at the centrosome of human-induced pluripotent stem cell-derived neural stem cells and neurons.
    [Science]

    AbstractGraphical AbstractPress Release
    Virtual Poster Presentation: CRISPR-Cas9 Gene Editing of Cerebral Organoids to Model Microcephaly
    PUBLICATIONSRanked by the impact factor of the journal

    Astrocytic Urea Cycle Detoxifies Aβ-Derived Ammonia While Impairing Memory in Alzheimer’s Disease

    Investigators reported that normal astrocytes showed non-cyclic urea metabolism, whereas beta-amyloid (Aβ)-treated astrocytes showed a switched-on urea cycle with upregulated enzymes and accumulated entering-metabolite aspartate, starting-substrate ammonia, end-product urea, and side-product putrescine.
    [Cell Metabolism]

    AbstractGraphical Abstract

    BACE-1 Inhibition Facilitates the Transition From Homeostatic Microglia to DAM-1

    Scientists reported that microglial β-site APP cleaving enzyme-1 (BACE-1) regulated the transition of homeostatic to stage 1 disease-associated microglia (DAM-1) signature.
    [Science Advances]

    Full Article

    Transcriptomics Analysis of Human iPSC-Derived Dopaminergic Neurons Reveals a Novel Model for Sporadic Parkinson’s Disease

    Researchers differentiated human induced pluripotent stem cells (iPSCs) into dopaminergic neurons, and subsequently exposed the cells to increasing concentrations of the neurotoxin MPP+.
    [Molecular Psychiatry]

    Abstract

    CEND1 Deficiency Induces Mitochondrial Dysfunction and Cognitive Impairment in Alzheimer’s Disease

    By proteomic analysis, scientists identified a new mitochondrial protein, cell-cycle exit and neuronal differentiation 1 (CEND1), which was decreased significantly in the brain of 5xFAD mice.
    [Cell Death & Differentiation]

    Full Article

    Activation of STAT3 Through Combined SRC and EGFR Signaling Drives Resistance to a Mitotic Kinesin Inhibitor in Glioblastoma

    Investigators reported that in glioblastoma, resistance to the Kif11 inhibitor ispinesib works through suppression of apoptosis driven by activation of STAT3.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Targeting EP2 Receptor With Multifaceted Mechanisms for High-Risk Neuroblastoma

    Researchers reported that the knockout of EP2 in neuroblastoma cells blocked the development of xenografts, and its conditional knockdown prevented established tumors from progressing.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Implementation of a Combined CDK Inhibition and Arginine-Deprivation Approach To Target Arginine-Auxotrophic Glioblastoma Multiforme Cells

    Three arginine-auxotrophic patient-derived glioblastoma multiforme lines with different molecular characteristics were cultured in 2D and 3D and the effects of this combined SpyADI/CDKi approach were analyzed in-depth.
    [Cell Death & Disease]

    Full Article

    Selective Cell Cycle Arrest in Glioblastoma Cell Lines by Quantum Molecular Resonance Alone or in Combination with Temozolomide

    Scientists reported that quantum molecular resonance affected cancer cell proliferation, inducing a significant arrest of cell cycle progression and reduction of cancer tumorigenicity.
    [British Journal of Cancer]

    Full Article

    Calpain-Mediated Cleavage Generates a ZBTB18 N-Terminal Product That Regulates HIF1A Signaling and Glioblastoma Metabolism

    Investigators reported that in glioblastoma, the tumor suppressor ZBTB18 was targeted for protein cleavage by the intracellular protease calpain.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Iron Commensalism of Mesenchymal Glioblastoma Promotes Ferroptosis Susceptibility Upon Dopamine Treatment

    Scientists reported that proneural-glioblastoma stem cells (GSCs) secreted dopamine and transferrin, inducing the proliferation of mesenchymal-GSCs and enhancing their susceptibility toward ferroptosis.
    [Communications Biology]

    Full Article

    Amyloid-β Impairs Mitochondrial Dynamics and Autophagy in Alzheimer’s Disease Experimental Models

    Researchers reported imbalances in the mitochondrial dynamics in the cerebral cortex and hippocampus of mice representing very early events in Alzheimer’s disease progression.
    [Scientific Reports]

    Full Article
    The complex genettics of schizophrenia are unclear. So she developed a new approach.
    REVIEWS

    Brain Cancer Stem Cells: Resilience Through Adaptive Plasticity and Hierarchical Heterogeneity

    The authors review the biological machinery used by brain tumor stem cells to commandeer tissues in the intracranial space, evade immune responses, and resist chemoradiotherapy.
    [Nature Reviews Cancer]

    Full Article

    Neuronal Hyperexcitability in Alzheimer’s Disease: What Are the Drivers Behind This Aberrant Phenotype?

    Investigators discuss contributors to aberrant neuronal excitability, including abnormal levels of intracellular Ca2+ and glutamate, pathological amyloid β and tau, genetic risk factors, including APOE, and impaired inhibitory interneuron and glial function.
    [Translational Psychiatry]

    Full Article
    INDUSTRY AND POLICY NEWS

    US FDA Awards Orphan Drug Designation (ODD) to Paxalisib for AT/RT, a Rare Form of Childhood Brain Cancer

    Kazia Therapeutics Limited announced that the US FDA has awarded ODD to Kazia’s paxalisib for the treatment of atypical rhabdoid/teratoid tumors, a rare and highly aggressive childhood brain cancer.
    [Kazia Therapeutics Limited]

    Press Release

    VBI Vaccines Receives US FDA Orphan Drug Designation for VBI-1901 for the Treatment of Glioblastoma

    VBI Vaccines, Inc. announced that the US FDA granted Orphan Drug Designation for VBI-1901, a bivalent gB/pp65 immunotherapeutic vaccine candidate for the treatment of glioblastoma.
    [VBI Vaccines Inc.]

    Press Release
    FEATURED EVENT

    Cell Bio 2022

    December 3 – 7, 2022
    Washington, DC, United States

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    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Alzheimer’s disease

    The University of Arizona – Tucson, Arizona, United States

    Director – iPSC NeuroCore

    Yale University – New Haven, Connecticut, United States

    Research Technologist – Pediatrics

    Pennsylvania State University – State College, Pennsylvania, United States

    Research Associate Positions – Cancer Metabolism

    The Ohio State University Comprehensive Cancer Center – Columbus, Ohio, United States

    Research Associate – Cancer Biology

    University of Bristol – Bristol, England, United Kingdom

    > See All Jobs

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