| Vol. 16.24 – 22 June, 2022 |
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| The authors used spatial proteomics to elucidate protein interaction networks at the centrosome of human-induced pluripotent stem cell-derived neural stem cells and neurons. [Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators reported that normal astrocytes showed non-cyclic urea metabolism, whereas beta-amyloid (Aβ)-treated astrocytes showed a switched-on urea cycle with upregulated enzymes and accumulated entering-metabolite aspartate, starting-substrate ammonia, end-product urea, and side-product putrescine. [Cell Metabolism] |
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| Scientists reported that microglial β-site APP cleaving enzyme-1 (BACE-1) regulated the transition of homeostatic to stage 1 disease-associated microglia (DAM-1) signature. [Science Advances] |
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| Researchers differentiated human induced pluripotent stem cells (iPSCs) into dopaminergic neurons, and subsequently exposed the cells to increasing concentrations of the neurotoxin MPP+. [Molecular Psychiatry] |
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| By proteomic analysis, scientists identified a new mitochondrial protein, cell-cycle exit and neuronal differentiation 1 (CEND1), which was decreased significantly in the brain of 5xFAD mice. [Cell Death & Differentiation] |
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| Investigators reported that in glioblastoma, resistance to the Kif11 inhibitor ispinesib works through suppression of apoptosis driven by activation of STAT3. [Cell Reports] |
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| Researchers reported that the knockout of EP2 in neuroblastoma cells blocked the development of xenografts, and its conditional knockdown prevented established tumors from progressing. [Cell Reports] |
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| Three arginine-auxotrophic patient-derived glioblastoma multiforme lines with different molecular characteristics were cultured in 2D and 3D and the effects of this combined SpyADI/CDKi approach were analyzed in-depth. [Cell Death & Disease] |
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| Scientists reported that quantum molecular resonance affected cancer cell proliferation, inducing a significant arrest of cell cycle progression and reduction of cancer tumorigenicity. [British Journal of Cancer] |
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| Investigators reported that in glioblastoma, the tumor suppressor ZBTB18 was targeted for protein cleavage by the intracellular protease calpain. [iScience] |
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| Scientists reported that proneural-glioblastoma stem cells (GSCs) secreted dopamine and transferrin, inducing the proliferation of mesenchymal-GSCs and enhancing their susceptibility toward ferroptosis. [Communications Biology] |
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| Researchers reported imbalances in the mitochondrial dynamics in the cerebral cortex and hippocampus of mice representing very early events in Alzheimer’s disease progression. [Scientific Reports] |
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| The authors review the biological machinery used by brain tumor stem cells to commandeer tissues in the intracranial space, evade immune responses, and resist chemoradiotherapy. [Nature Reviews Cancer] |
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| Investigators discuss contributors to aberrant neuronal excitability, including abnormal levels of intracellular Ca2+ and glutamate, pathological amyloid β and tau, genetic risk factors, including APOE, and impaired inhibitory interneuron and glial function. [Translational Psychiatry] |
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| Kazia Therapeutics Limited announced that the US FDA has awarded ODD to Kazia’s paxalisib for the treatment of atypical rhabdoid/teratoid tumors, a rare and highly aggressive childhood brain cancer. [Kazia Therapeutics Limited] |
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| VBI Vaccines, Inc. announced that the US FDA granted Orphan Drug Designation for VBI-1901, a bivalent gB/pp65 immunotherapeutic vaccine candidate for the treatment of glioblastoma. [VBI Vaccines Inc.] |
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| December 3 – 7, 2022 Washington, DC, United States |
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| The University of Arizona – Tucson, Arizona, United States |
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| Yale University – New Haven, Connecticut, United States |
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| Pennsylvania State University – State College, Pennsylvania, United States |
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| The Ohio State University Comprehensive Cancer Center – Columbus, Ohio, United States |
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| University of Bristol – Bristol, England, United Kingdom |
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