 | | Vol. 16.26 – 6 July, 2022 |
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| Scientists showed that CUG foci found early in the maturation of 3D cortical organoids from dystrophy type 1 patient-derived induced pluripotent stem cells caused hyperphosphorylation of CUGBP Elav-like family member 2 protein.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using multi-dimensional metabolic profiling in MYCN expression systems and primary patient tumors, researchers comprehensively characterized the metabolic landscape driven by MYCN in neuroblastoma.
[Nature Communications] |
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| Investigators demonstrated that temozolomide (TMZ) treatment significantly upregulated the expression of guanylate binding protein 3 and stimulator of interferon genes, both of which increased TMZ-induced DNA damage repair and reduced cell apoptosis of glioblastoma cells.
[Oncogene] |
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| Using Biolog microplate-1 mitochondrial functional assay, scientists confirmed that the depletion of Galectin-1 increased the expression levels of the enzymes from the tricarboxylic acid cycle, suggesting a reversal of the Warburg phenotype.
[Cell Death & Disease] |
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| Using in vitro cultures, the authors discovered that soluble factors secreted from activated microglia promoted cell-to-cell propagation of α-synuclein and further showed that among these soluble factors, TNF-α had the most robust stimulatory activity.
[Experimental and Molecular Medicine] |
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| Scientists reported an association between human glycoprotein stanniocalcin-2 and aggressive glioblastoma multiforme progression and demonstrated the underlying mechanism.
[Cell Death Discovery] |
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| Researchers investigated how drug treatments impacted stemness marker expression of glioblastoma multiforme cells in multicellular tumor spheroid models.
[Biotechnology Progress] |
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| The authors discuss the development of cerebral organoids, their recent applications in the study of both syndromic and idiopathic autism spectrum disorders (ASDs), their use as an ASD drug development platform, as well as limitations of their use in ASD research.
[Gene Therapy] |
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| Investigators summarize the roles and mechanisms of circRNAs in the development of glioma.
[Journal of Cancer Research and Clinical Oncology] |
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| Scientists summarize the potential aspects and mechanisms by which thymoquinone imparts its action in Alzheimer’s disease.
[Heliyon] |
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| Pyramid Biosciences, Inc. announced that the US FDA has granted orphan drug designation for PBI-200, a highly brain penetrant inhibitor of the neurotrophic tyrosine receptor kinase (NTRK) currently in clinical development for the treatment of NTRK fusion-positive solid tumors.
[Pyramid Biosciences, Inc.] |
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| Intravacc and the German Center for Neurogenerative Diseases (DZNE), have been awarded funding of €2.5 million from the European Union to further develop a prototype ALS vaccine, including process development, scale-up, and toxicology study.
[Intravacc] |
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| December 10 – 14, 2022
Maui, Hawai’i, United States |
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| | Delft University of Technology – Delft, Netherlands |
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| | University of Rochester Medical Center – Rochester, New York, United States |
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| | UF Scripps Biomedical Research – Jupiter, Florida, United States |
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| | Johns Hopkins Medicine – Baltimore, Maryland, United States |
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| | The Scripps Research Institute – La Jolla, California, United States |
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