 | | Vol. 16.28 – 20 July, 2022 |
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| Researchers identified ribonucleotide reductase subunit M2 (RRM2) as a candidate dependency factor further supported by growth inhibition upon in vitro knockdown.
[Science Advances] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported that astrocytes, especially those cultured from the ventral midbrain, showed therapeutic potential to alleviate α-synuclein (α-syn) pathology in multiple in vitro and in vivo α-syn models.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Using a genetic model of glial cell ablation, the authors found that glial cell loss resulted in transient peripheral nervous system demyelination without overt axonal loss
[Cell Reports] |
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| Scientists reported that circWDR62 expression was upregulated in Temozolomide (TMZ)-resistant glioma cells and TMZ-resistant glioma cell-derived exosomes compared with their controls by using high-throughput microarray analysis and quantitative real-time PCR.
[Cell Death & Disease] |
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| Investigators used induced pluripotent stem cells derived cortical neuronal cells carrying 3 different PSEN1 mutations, to investigate the effect of treatment with the selective serotonin reuptake inhibitor, Citalopram on Amyloid-β Precursor Protein (AβPP) processing and oxidative stress.
[Translational Psychiatry] |
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| Researchers developed an autaptic culture system containing single neuron cultures grown on microislands of astrocytes.
[iScience] |
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| Scientists demonstrated that the MEK inhibitor, selumetinib, decreased human Sonic Hedgehog (SHH) medulloblastoma growth while extending survival in mouse models.
[Communications Biology] |
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| Researchers studied the effects of different combinations of miRNAs in glioblastoma cells by delivering synthetic miRNAs using clinically compatible PLGA-PEG nanoparticles prior to treatment with temozolomide or doxorubicin.
[Scientific Reports] |
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| Investigators reported that uptake alone regulated the levels and signaling activity of the CD44 receptor, decreasing stemness, invasive properties and proliferation of the CD44-tumor initiating cells populations in vitro and in a patient-derived xenograft zebrafish model.
[Scientific Reports] |
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| Investigators reported methods for culturing adult central nervous system (CNS) neurons in large numbers and across multiple brain regions for extended time periods.
[Cell Reports Methods] |
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| The authors provide a cross-species view of the behavioral manifestations, proximate and ultimate drives, and neural mechanisms of prosocial behaviors.
[Trends in Neurosciences] |
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| Impel Pharmaceuticals announced the first subject has been dosed in a Phase IIa proof-of-concept study of INP105, nasal olanzapine, a widely used atypical, second-generation antipsychotic.
[Impel Pharmaceuticals] |
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| August 7 – 12, 2022
Castelldefels, Spain |
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| | University of Lausanne – Lausanne, Vaud, Switzerland |
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| | Sarepta Therapeutics Inc. – Columbus, Ohio, United States |
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| | University of Twente – Enschede, Netherlands |
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| | Delft University of Technology – Delft, Netherlands |
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| | University of Rochester Medical Center – Rochester, New York, United States |
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