Neural Cell News Volume 16.29 | Jul 27 2022

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    2022-07-27 | NCN 16.29


    Neural Cell News by STEMCELL Technologies
    Vol. 16.29 – 27 July, 2022
    TOP STORY

    Microglia-Derived PDGFB Promotes Neuronal Potassium Currents to Suppress Basal Sympathetic Tonicity and Limit Hypertension

    Investigators found that microglia prevented overactivation of pre-sympathetic neurons in the hypothalamic paraventricular nucleus at steady state.
    [Immunity]

    AbstractGraphical Abstract
    Try proven workflows for your hPSC culture. Click to request your offer now.
    PUBLICATIONSRanked by the impact factor of the journal

    The First-in-Class ERK Inhibitor Ulixertinib Shows Promising Activity in MAPK-Driven Pediatric Low-Grade Glioma Models

    Researchers investigated the anti-tumoral activity of ulixertinib monotherapy as well as in combination with MEK inhibitors, BH3-mimetics, or chemotherapy in pediatric low-grade gliomas.
    [Neuro-Oncology]

    Abstract

    miR-124-Dependent Tagging of Synapses by Synaptopodin Enables Input-Specific Homeostatic Plasticity

    Investigators reported a synaptic tagging mechanism in which the ability of individual synapses to increase their strength in response to activity deprivation depends on the local expression of the spine-apparatus protein synaptopodin under the regulation of miR-124.
    [EMBO Journal]

    Full ArticleGraphical Abstract

    Fusion between Glioma Stem Cells and Mesenchymal Stem Cells Promotes Malignant Progression in 3D-Bioprinted Models

    Cell fusion between glioma stem cells and mesenchymal stem cells was found by the method of Cre-LoxP switch gene and RFP/GFP dual-color fluorescence tracing.
    [ACS Applied Materials & interfaces]

    AbstractGraphical Abstract

    Establishment and Characterization of Human Pluripotent Stem Cells-Derived Brain Organoids to Model Cerebellar Diseases

    Brain organoids were characterized regarding brain development, cell type composition, and Machado-Joseph disease-associated neuropathology markers, to evaluate their value for cerebellar diseases modeling.
    [Scientific Reports]

    Full Article

    Human iPSC Co-culture Model to Investigate the Interaction between Microglia and Motor Neurons

    Scientists combined both cell lineages and establish a novel co-culture of induced pluripotent stem cell (iPSC)-derived spinal motor neurons and microglia, which was compatible with motor neuron identity and function.
    [Scientific Reports]

    Full Article

    In Situ Detection of Protein-Protein Interaction by Proximity Ligation Assay in Patient Derived Brain Tumor Stem Cells

    The authors described an adapted proximity ligation assay protocol for the assessment of galectin-1-HOXA5 interaction in brain tumor stem cells.
    [STAR Protocols]

    Full ArticleGraphical Abstract

    A Labroots 2021 Webinar: iPSCs As Models, Part 2: Modeling the Human Brain with Organoids, presented by Dr. Anjana Nityanandam, Director of the Human Stem Cell Lab core facility at St. Jude Children’s Research Hospital. Click to Watch Now.
    REVIEWS

    COVID-19 and Olfactory Dysfunction: A Looming Wave of Dementia?

    Long-term olfactory dysfunction coupled with cognitive and emotional disturbance from COVID-19 may be the first signs of delayed onset dementia from neurodegeneration.
    [Journal of Neurophysiology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Blots on a Field?

    A neuroscience image sleuth finds signs of fabrication in scores of Alzheimer’s articles, threatening a reigning theory of the disease.
    [ScienceInsider]

    Press Release
    FEATURED EVENT

    The Translational Neuroimmunology Conference: From Bench to Bedside and Back

    August 28 – September 2, 2022
    Asheville, North Carolina, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Cancer Biology and Immunotherapies

    Sanford Research – Sioux Falls, South Dakota, United States

    Postdoctoral Scholar – Protein Degradation in Cancer and Alzheimer’s

    Virginia Commonwealth University – Richmond, Virginia, United States

    Postdoctoral Positions – Vascular Pathomechanisms

    University of Lausanne – Lausanne, Switzerland

    Histologist – Muscle & Nerve Tissue

    Sarepta Therapeutics, Inc. – Columbus, Ohio, United States

    PhD Position – Pluripotent Stem Cell-Derived Gut-Brain Axis

    University of Twente – Enschede, Netherlands

    > See All Jobs

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