CURRENT PUBLICATIONS
Cargo Recognition Failure is Responsible for Inefficient Autophagy in Huntington’s Disease Researchers propose that inefficient engulfment of cytosolic components by autophagosomes is responsible for their slower turnover, functional decay and accumulation inside Huntington’s disease cells. [Nat Neurosci]
Pro-Survival Role for Parkinson’s Associated Gene DJ-1 Revealed in Trophically Impaired Dopaminergic Neurons Investigators uncover a conserved interaction between DJ-1 and Ret-mediated signaling and a novel cell survival role for DJ-1 in the mouse. [PLoS Biol]
Transgenic Ablation of Doublecortin-Expressing Cells Suppresses Adult Neurogenesis and Worsens Stroke Outcome in Mice Findings provide evidence that injury-induced neurogenesis contributes to stroke outcome and might therefore be a target for stroke therapy. [Proc Natl Acad Sci U S A]
A Nerve Graft Constructed with Xenogeneic Acellular Nerve Matrix and Autologous Adipose-Derived Mesenchymal Stem Cells Researchers constructed a nerve regeneration characteristics-containing nerve graft through integrating xenogeneic acellular nerve matrix with autologous neural differentiated adipose-derived mesenchymal stem cells. [Biomaterials]
Ectopic Expression of Alpha-Synuclein Affects the Migration of Neural Stem Cells in Mouse Subventricular Zone Researchers investigated neurosphere formation in vitro and migration of neuronal stem cells (NSC) in vivo after transduction of alphaSyn-encoding retroviral vector to characterize the function of alphaSyn in NSC. [J Neurochem]
Cerebrospinal Fluid Promotes Survival and Astroglial Differentiation of Adult Human Neural Progenitor Cells but Inhibits Proliferation and Neuronal Differentiation Adult human leptomeningeal cerebrospinal fluid creates a beneficial environment for the survival and differentiation of adult human neural stem cells. [BMC Neurosci]
Proliferation, Migration, and Neuronal Differentiation of the Endogenous Neural Progenitors in Hippocampus After Fimbria Fornix Transection To determine whether denervation stimulates neurogenesis in hippocampus, proliferation, migration, and differentiation, of local neural stem cells in dentate gyrus was investigated after fimbria fornix transection. [Int J Neurosci]
Dynamic Dependence on ATR and ATM for Double-Strand Break Repair in Human Embryonic Stem Cells and Neural Descendants Human embryonic stem cells have efficient double-strand break repair that is largely ATR-dependent homologous recombination repair, whereas astrocytes critically depend on ATM for nonhomologous end joining, which, in part, is DNA-PKcs-independent. [PLoS One]
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