TOP STORY Motor Neurone Study into Key Gene University researchers are leading a study that will enable them to model motor neurone disease in the laboratory. The research focuses on a gene which is believed to be relevant to more than 90 per cent of cases. [The University of Edinburgh Press Release]
|
SCIENCE NEWS
Atlas of Gene Activity in Human Brain Launches The Allen Institute for Brain Science has launched its map of gene expression in the human brain. [ScienceInsider Press Release] Protein Regulates Enzyme Linked to Alzheimer’s Disease Researchers have zeroed in on a protein that may play a role in the progression of Alzheimer’s disease. The team found that increasing levels of the protein (called GGA3) prevented the accumulation of an enzyme linked to Alzheimer’s. [Press release from Tufts University discussing online prepublication in The Journal of Biological Chemistry] Pipeline Robust for Treatment of Depression, but Studies in Children Still Rare The drug development pipeline for the future treatment of major depressive disorder (MDD) is robust, based on the number and types of clinical trials in progress, according to investigators who described the clinical trial landscape. [Press release from Medscape Today discussing research presented at the American Psychiatric Association (APA) 2010 Annual Meeting] Progress in Exploring New Avenues for Brain Repair Researchers showed how astroglia can be directly converted into the two main classes of cortical neurons. [Press release from Ludwig-Maximilians University discussing online prepublication in PLoS Biology]
|
CURRENT PUBLICATIONS
Cdk5rap2 Interacts with Pericentrin to Maintain the Neural Progenitor Pool in the Developing Neocortex Researchers find that one of the genes associated with microcephaly, Cdk5rap2, is highly expressed in the neural progenitor pool and that its loss results in a depletion of apical progenitors and increased cell-cycle exit leading to premature neuronal differentiation. [Neuron] Abrupt Transitions between Prefrontal Neural Ensemble States Accompany Behavioral Transitions during Rule Learning Here, researchers employed advanced statistical techniques to visualize the trajectories of ensembles of simultaneously recorded medial prefrontal cortex neurons on a trial-by-trial basis as rats deduced a novel rule in a set-shifting task. [Neuron] Asymmetric Clathrin-Mediated Endocytosis Drives Repulsive Growth Cone Guidance Here, researchers show that clathrin-mediated endocytosis acts downstream of Ca2+ signals as driving machinery for growth cone turning. [Neuron] Integrin Signaling Switches the Cytoskeletal and Exocytic Machinery that Drives Neuritogenesis Researchers report that regulated membrane delivery coordinated with the actin cytoskeleton is crucial for neuritogenesis and identify two independent pathways that use distinct exocytic and cytoskeletal machinery to drive neuritogenesis. [Dev Cell] Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons Researchers show that strong and persistent expression of neurogenic fate determinants driven by silencing-resistant retroviral vectors instructs astroglia from the postnatal cortex in vitro to mature into fully functional, synapse-forming neurons. [PLoS Biology] Ephb3 Inhibits the Expansion of Neural Progenitor Cells in the SVZ by Regulating p53 During Homeostasis and Following Traumatic Brain Injury Here, researchers examined the role of ephrinB3-EphB3 signaling in mediating the subventricular zone (SVZ) response to traumatic brain injury. [Stem Cells] Control of Extracellular Dopamine at Dendrite and Axon Terminals The conclusion is that the time course of dopamine within the extracellular space of the ventral tegmental area is dependent on both diffusion and reuptake, whereas the activation of D2 receptors on dopamine neurons is primarily limited by reuptake. [J Neurosci] Presenilin 1 Mutants Impair the Self-Renewal and Differentiation of Adult Murine Subventricular Zone-Neuronal Progenitors via Cell-Autonomous Mechanisms Involving Notch Signaling Researchers show that viral expression of several presenilin 1 mutants in neural progenitors leads to impaired self-renewal and altered differentiation toward neuronal lineage, in vitro. [J Neurosci] Smad7 Regulates the Adult Neural Stem/Progenitor Cell Pool in a TGF-Beta and BMP-Independent Manner Here, researchers investigated neurogenesis in a hypomorphic mouse model for the TGF-beta and bone morphogenetic protein (BMP) inhibitor Smad7, with the hypothesis that neural stem and progenitor cell proliferation might be reduced due to increased TGF-beta and BMP signaling. [Mol Cell Biol] Ubiquitin Regulates GGA3-Mediated Degradation of BACE1 Here, researchers report that the accumulation of beta-site APP-cleaving enzyme 1 (BACE1) is rescued by the ectopic expression of golgi-localized gamma-ear-containing ARF binding protein 3 (GGA3) in H4 neuroglioma cells depleted of GGA3. [J Biol Chem] Neural Differentiation from Human Embryonic Stem Cells as a Tool to Study Early Brain Development and the Neuroteratogenic Effects of Ethanol Using in vitro culture, researchers demonstrate that ethanol exposure, impairs neural progenitors (NPs) survival, affects the differentiation of NPs into neurons and astrocytes, disrupts the actin cytoskeleton and affects the expression of different genes associated with neural differentiation. [Stem Cells Dev] Neural Precursor Cell Proliferation is Disrupted through Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) This study tested the hypothesis that aryl hydrocarbon receptor activation by TCDD disrupts signaling events that regulate neural precursor cell proliferation. [Stem Cells Dev]
|
INDUSTRY NEWS
Rensselaer Polytechnic Institute Wins $2.45 Million Grant To Support Stem Cell Research Rensselaer Polytechnic Institute and principal investigator Glenn Monastersky have been awarded a four-year $2.45 million grant from the New York Stem Cell Science Program of the Empire State Stem Cell Board. [Rensselaer Polytechnic Institute Press Release] Neuralstem Updates Clinical Trial Progress Neuralstem, Inc. updated the progress of its ongoing Phase I human clinical trial to treat Amyotrophic Lateral Sclerosis at Emory University in Atlanta, Georgia. [Neuralstem, Inc. Press Release] Podcasts Dedicated to the Latest Neuromuscular Research Hosted by Kevin Flanigan, M.D., “This Month in Muscular Dystrophy” podcasts highlight the latest in muscular dystrophy and other inherited neuromuscular disease research. [Nationwide Children’s Hospital Press Release] Neurologist Lyden Named Carmen and Louis Warschaw Chair in Neurology During Dedication Ceremony at Cedars-Sinai One of the nation’s leading neurologists, Patrick D. Lyden, M.D., has been named the Carmen and Louis Warschaw Chair in Neurology at Cedars-Sinai Medical Center. [Newswise] Donald W. Pfaff and Bruce S. McEwen will Share 2010 Foundation Ipsen Neuronal Plasticity Prize Donald W. Pfaff and Bruce S. McEwen have been named recipients of the 2010 Foundation Ipsen Neuronal Plasticity Prize for their studies on the neuroendocrine control of behavior. They share the prize with Thomas R. Insel, director of the National Institute of Mental Health. [Rockefeller University Press Release] $1.5 Million Award to Neuroscience Program Neuroscience undergraduates will get broader laboratory experience, thanks to a $1.5 million grant from the Howard Hughes Medical Institute that bolsters Boston University’s increasingly popular brain research program. [Boston University Press Release] Chapman Medical in Orange Opens Neuroscience and Spine Facility Chapman Medical Center in Orange is looking to increase patient access to advanced spinal and neurological treatments with its new facility. [OC Metro]
|
EVENTS
Stem Cell Investor & Executive Networking Conference Event (S.C.I.E.N.C.E.) June 1, 2010 New York, United States The Future of Molecular Epidemiology: New Tools, Biomarkers, and Opportunities June 6-9, 2010 Miami, United States 8th International Conference on Cell and Stem Cell Engineering June 11-12, 2010 Dublin, Ireland International Society for Stem Cell Research (ISSCR) 8th Annual Meeting June 16-19, 2010 San Francisco, United States BIT’s 1st World Congress of NeuroTalk 2010 June 25-28, 2010 Singapore City, Singapore 7th Federation of European Neuroscience Societies (FENS) Forum of European Neuroscience July 3-7, 2010 Amsterdam, The Netherlands Translational Cancer Medicine 2010 – USA July 11-14, 2010 San Francisco, United States United Kingdom National Stem Cell Network (UKNSCN) Annual Scientific Conference July 12-14, 2010 Nottingham, United Kingdom Select BioSciences 3rd Annual Stem Cells Europe Conference August 24-25, 2010 Edinburgh, Scotland Joint Metastasis Research Society – American Association of Cancer Research Conference on Metastasis and the Tumor Microenvironment September 12-15, 2010 Philadelphia, United States Stem Cells USA & Regenerative Medicine Congress 2010 September 13-15, 2010 Philadelphia, United States 4th American Association of Cancer Research International Conference on Molecular Diagnostics in Cancer Therapeutic Development September 27-30, 2010 Denver, United States 6th International Symposium on Neuroprotection and Neurorepair October 1-4, 2010 Rostock, Germany 2010 World Stem Cell Summit October 4-6, 2010 Detroit, United States Translational Cancer Research for Basic Scientists October 17-22, 2010 Boston, United States Fraunhofer Life Science Symposium 2010 October 29-30, 2010 Leipzig, Germany Stem Cell Society Singapore Symposium 2010: Translating Science to Therapy November 2-3, 2010 Singapore City, Singapore 40th Annual Meeting of the Society for Neuroscience 2010 November 13-17, 2010 San Diego, United States Stem Cell Network 10th Annual Scientific Meeting November 22-24, 2010 Calgary, Canada Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
JOB OPPORTUNITIES Senior Scientist – Magnetic Cell Separation (STEMCELL Technologies) Business Development Manager Europe – Cell Therapy Products (Pall Corporation) Manager/Sr. Manager, Therapeutic Cell Solutions, Process Development (Lonza) Sr. Product Support and Training Specialist (CardianBCT) Recruit Top Talent Reach more than 11,000 potential candidates by posting your organization’s career opportunities with Neural Cell News. Visit here to post your career opportunities.
|
|