Mutations in UBQLN2 Cause Dominant X-Linked Juvenile and Adult-Onset ALS and ALS/Dementia Here scientists show that mutations in UBQLN2, which encodes the ubiquitin-like protein ubiquilin-2, cause dominantly inherited, chromosome-X-linked amyotrophic lateral sclerosis (ALS) and ALS/dementia. [Nature] Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons Here researchers report that the forced expression of select transcription factors is sufficient to convert mouse and human fibroblasts into induced motor neurons. [Cell Stem Cell] Spatial Gradients and Multidimensional Dynamics in a Neural Integrator Circuit Researchers used optical recording to measure the time constant of decay of persistent firing (persistence time) across a population of neurons comprising the larval zebrafish oculomotor velocity-to-position neural integrator. [Nat Neurosci] miR-124a Is Required for Hippocampal Axogenesis and Retinal Cone Survival Through Lhx2 Suppression The results suggest that microRNA-124a (miR-124a) is essential for the maturation and survival of dentate gyrus neurons and retinal cones, as it represses Lhx2 translation. [Nat Neurosci] v-SNARE Composition Distinguishes Synaptic Vesicle Pools The results suggest that different endocytic mechanisms generate synaptic vesicles with different proteins that can endow the vesicles with distinct properties. [Neuron] ADP Ribosylation Factor 6 (ARF6) Controls Amyloid Precursor Protein (APP) Processing by Mediating the Endosomal Sorting of BACE1 The results demonstrate a spatial separation between APP and ß-site APP cleaving enzyme 1 (BACE1) during surface-to-endosome transport, suggesting subcellular trafficking as a regulatory mechanism for this proteolytic processing step. [Proc Natl Acad Sci USA] Neural Stem Cells Maintain Their Stemness Through Protein Kinase C ζ-Mediated Inhibition of TRIM32 Here, researchers provide evidence that the neuronal fate determinant TRIM32 binds to the protein kinase C ζ. Through this interaction, TRIM32 is retained in the cytoplasm. [Stem Cells] Cellular-Resolution Population Imaging Reveals Robust Sparse Coding in the Drosophila Mushroom Body Here researchers used two-photon imaging to record neural activity in the relatively simple Drosophila mushroom body, an area involved in olfactory learning and memory. [J Neurosci] Gcm/Glide-Dependent Conversion into Glia Depends on Neural Stem Cell Age, but Not on Division, Triggering a Chromatin Signature That Is Conserved in Vertebrate Glia Researchers show here that overexpression of the Gcm transcription factor, which controls the glial versus neuronal fate choice, fully and efficiently converts Drosophila neural stem cells towards the glial fate via an intermediate state. [Development] Parkinson’s Disease Induced Pluripotent Stem Cells with Triplication of the α-Synuclein Locus The model represents a new experimental system to identify compounds that reduce levels of α-synuclein, and to investigate the mechanistic basis of neurodegeneration caused by α-synuclein dysfunction. [Nat Commun] |