Self-Renewal Does Not Predict Tumor Growth Potential in Mouse Models of High-Grade Glioma Using PDGF- and KRAS-driven murine models of gliomagenesis, researchers show that high Id1 expression identifies tumor cells with high self-renewal capacity, while low Id1 expression identifies tumor cells with proliferative potential but limited self-renewal capacity. [Cancer Cell] Abstract A Role for mDia, a Rho-Regulated Actin Nucleator, in Tangential Migration of Interneuron Precursors Investigators examined neuronal migration in mice deficient in mDia1 (also known as Diap1) and mDia3 (also known as Diap2), which encode the Rho-regulated actin nucleators mammalian diaphanous homolog 1 (mDia1) and mDia3. [Nat Neurosci] Abstract Postsynaptic Density Protein 95 (PSD-95) Is Post-Transcriptionally Repressed during Early Neural Development by Polypyrimidine Tract Binding Protein 1 (PTBP1) and PTBP2 Researchers found that Psd-95 was controlled post-transcriptionally during neural development. [Nat Neurosci] Abstract Mitochondrial Dysfunction and Purkinje Cell Loss in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) Scientists have generated an animal model for ARSACS, sacsin knockout mice, that display age-dependent neurodegeneration of cerebellar Purkinje cells. To explore the pathophysiological basis for this observation, researchers examined the cell biological properties of sacsin. [Proc Natl Acad Sci USA] Abstract | Press Release Loss of Autophagy in Hypothalamic POMC Neurons Impairs Lipolysis Researchers show that selective loss of autophagy in hypothalamic proopiomelanocortin (POMC) neurons decreases α-melanocyte-stimulating hormone levels, promoting adiposity, impairing lipolysis and altering glucose homeostasis. [EMBO Rep] Abstract Improved Outcome after Peripheral Nerve Injury in Mice with Increased Levels of Endogenous Omega-3 Polyunsaturated Fatty Acids The objective of this study was to assess the neuroprotective and pro-regenerative potential of ω-3 polyunsaturated fatty acids in peripheral nerve injury. [J Neurosci] Abstract | Press Release Prenatal NMDA Receptor Antagonism Impaired Proliferation of Neuronal Progenitor, Leading to Fewer Glutamatergic Neurons in the Prefrontal Cortex Here, investigators report that prenatal N-methyl-D-aspartate (NMDA) receptor antagonism impaired the proliferation of neuronal progenitors, leading to a decrease in the progenitor pool in the ventricular and the subventricular zone. [Neuropsychopharmacology] Abstract The Oncogenic RNA-Binding Protein Musashi1 Is Regulated by HuR via mRNA Translation and Stability in Glioblastoma Cells Researchers’ results suggest that HuR is an important regulator of Musashi1 in glioblastoma and that this regulation has important biological consequences during gliomagenesis. [Mol Cancer Res] Abstract | Press Release |