Mitochondrial CB1 Receptors Regulate Neuronal Energy Metabolism Here investigators show that the type-1 cannabinoid receptor (CB1) is present at the membranes of mouse neuronal mitochondria, where it directly controls cellular respiration and energy production. [Nat Neurosci] Abstract The Growth Factor SVH-1 Regulates Axon Regeneration in C. elegans via the Jun N-Terminal Kinase MAP Kinase Cascade Researchers found that the Caenorhabditis elegans SVH-1 growth factor and its receptor, SVH-2 tyrosine kinase, regulate axon regeneration. [Nat Neurosci] Abstract Active Dendrites Support Efficient Initiation of Dendritic Spikes in Hippocampal CA3 Pyramidal Neurons Scientists used confocally targeted patch-clamp recording from dendrites and axons to map the activation of rat CA3 pyramidal neurons at the subcellular level. [Nat Neurosci] Abstract Cyclin D2 in the Basal Process of Neural Progenitors Is Linked to Non-Equivalent Cell Fates Here, researchers identify a novel mechanism for generating cellular asymmetry through the active transportation and local translation of Cyclin D2 mRNA in the basal process. [EMBO J] Abstract Injury-Independent Induction of Reactive Gliosis in Retina by Loss of Function of the LIM Homeodomain Transcription Factor Lhx2 Investigators report that selective deletion of the LIM homeodomain transcription factor Lhx2 from mature Müller glia leads to the induction of reactive retinal gliosis in the absence of injury. [Proc Natl Acad Sci USA] Abstract Inhibition of Drp1 Provides Neuroprotection In Vitro and In Vivo Here, researchers investigated the role of dynamin-related protein 1 (Drp1) in neuronal cell death induced by glutamate toxicity or oxygen-glucose deprivation in vitro, and after ischemic brain damage in vivo. [Cell Death Differ] Abstract Reduced Expression of BTBD10, an Akt Activator, Leads to Motor Neuron Death Overexpression of BTBD10 suppresses motor neuron death that is induced by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 (SOD1) mutant, G93A-SOD1 in vitro. In this study, researchers further investigated the BTBD10-mediated suppression of motor neuron death. [Cell Death Differ] Abstract Notch Signaling Controls Generation of Motor Neurons in the Lesioned Spinal Cord of Adult Zebrafish This research demonstrates that Notch is a negative signal for regenerative neurogenesis, and that spinal motor neuron regeneration can be augmented in an adult vertebrate by inhibiting Notch signaling. [J Neurosci] Abstract | Press Release A Novel “Molecular Tweezer” Inhibitor of α-Synuclein Neurotoxicity In Vitro and In Vivo To determine if CLR01 was protective in vivo, researchers used a novel zebrafish model of α-synuclein (α-syn) toxicity, which expresses human, wild-type α-syn in neurons. [Neurotherapeutics] Abstract | Press Release LIS1-Dependent Retrograde Translocation of Excitatory Synapses in Developing Interneuron Dendrites Here researchers show that immature dendrites of γ-aminobutyric acid-positive interneurons form long protrusions and that these protrusions serve as conduits for retrograde translocation of synaptic contacts to the parental dendrites. [Nat Commun] Abstract |