Neural Cell News Volume 6.15 | Apr 18 2012

Sox9 and NFIA Coordinate a Transcriptional Regulatory Cascade during the Initiation of Gliogenesis
Researchers delineated a transcriptional regulatory cascade that operates during the initiation of gliogenesis and identified a unique set of genes that regulate key aspects of astro-glial precursor physiology during development. [Neuron] Abstract

Intralineage Directional Notch Signaling Regulates Self-Renewal and Differentiation of Asymmetrically Dividing Radial Glia
With single-cell resolution, researchers revealed how self-renewal and differentiation become precisely segregated within asymmetrically dividing neural progenitor/stem lineages. [Neuron] Abstract

Calcium-Activated Chloride Channels (CaCCs) Regulate Action Potential and Synaptic Response in Hippocampal Neurons
Researchers present evidence that CaCCs reside in hippocampal neurons and are in close proximity of calcium channels and NMDA receptors to shorten action potential duration, dampen excitatory synaptic potentials, impede temporal summation, and raise the threshold for action potential generation by synaptic potential. [Neuron] Abstract

The Ubiquitin Ligase mLin41 Temporally Promotes Neural Progenitor Cell Maintenance through Fibroblast Growth Factor Signaling
Researchers showed that mouse Lin41 (mLin41) is highly expressed in neural progenitor cells and its expression declines during neural differentiation. [Genes Dev] Abstract | Press Release

Nurr1 Protein Is Required for N-Methyl-D-Aspartic Acid (NMDA) Receptor-Mediated Neuronal Survival
Researchers obtained whole genome expression profiles after three and eight hours of NMDA addition to identify genes involved in NMDA-mediated survival of cerebellar granule cells. [J Biol Chem]
Abstract | Press Release

Conditional Deletion of the Notch1 and Notch2 Genes in Excitatory Neurons of the Postnatal Forebrain Does Not Cause Neurodegeneration or Reduction of Notch mRNAs and Proteins
Researchers demonstrated that Notch1 and Notch2 are not involved in the age-related neurodegeneration caused by loss of presenilin or γ-secretase, and suggest that there is no detectable expression of Notch1 and Notch2 in pyramidal neurons of the adult cerebral cortex. [J Biol Chem] Abstract

A Preclinical Assessment of Neural Stem Cells as Delivery Vehicles for Anti-Amyloid Therapeutics
Researchers conducted a small preclinical investigation of whether neural stem cells could be modified to express metalloproteinase 9. [PLoS One] Abstract

Multiple Phenotypes in Huntington Disease Mouse Neural Stem Cells
Scientists established neural stem (NS) cells for cellular studies of Huntington’s disease (HD) and suggest that NS cells expressing endogenous mutant Huntingtin will be useful for studying the mechanisms of HD and drug discovery. [Mol Cell Neurosci] Abstract

Disturbed Apoptosis and Cell Proliferation in Developing Neuroepithelium of Lumbo-Sacral Neural Tubes in Retinoic Acid-Induced Spina Bifida Aperta in Rat
Researchers investigated cell apoptosis in whole embryos and proliferation of neural progenitor cells in the spinal neural tube during neurulation in all-trans retinoic acid-induced spina bifida in fetal rats. [Int J Dev Neurosci] Abstract

Murine Model Developed by Researchers May Offer New Opportunities to Investigate Medical, Surgical Treatments of Neocortical Epilepsy
Researchers developed a novel neocortical epilepsy model via the inducement of over-expression of adenosine kinase in cortical astrocytes of mice. [Press Release from the American Association of Neurological Surgeons (AANS) discussing research presented at the 80th Annual Scientific Meeting of the AANS, Miami] Press Release

King’s Is Part of World-First Parkinson’s Disease Study
King’s College Hospital will start their contribution to the world’s biggest Parkinson’s Disease study. Over £1.5 million is being invested by the Parkinson’s UK charity into the ‘Tracking Parkinson’s’ study, to try and unlock further secrets about the disease and to boost the chances of finding a cure. [King’s College Hospital] Press Release

Dr Barry Snow to Lead Parkinson’s Trial for Living Cell Technologies
Living Cell Technologies Limited announced that Dr Barry Snow has agreed to be the Principal Investigator for its Phase I clinical trials of NTCELL for Parkinson’s disease. [Living Cell Technologies Limited]
Press Release

Piramal Healthcare Limited Acquires Molecular Imaging Development Portfolio of Bayer Pharma
Piramal Healthcare Limited announced that it has signed an agreement to acquire worldwide rights to the molecular imaging research and development portfolio of Bayer Pharma AG through its newly created subsidiary – Piramal Imaging SA. [Piramal Healthcare Limited] Press Release
 
The Alzheimer’s Drug Discovery Foundation and Charles River Announce Awards for the Cognitive Aging and Alzheimer’s Disease Research Program
The Alzheimer’s Drug Discovery Foundation/Charles River program awarded $225,000 to two academic research scientists testing novel compounds in aged rats. [Charles River Laboratories International, Inc.] Press Release

Extension of Expiration Date for PAR-11-293, NINDS Exploratory/Developmental Projects in Translational Research (R21) (NOT-NS-12-010) [National Institutes of Health, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Hydra VIII 2012: European Summer School on Stem Cells & Regenerative Medicine
September 15-21, 2012
Hydra, Greece

Visit our events page to see a complete list of events in the neural cell community.

Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Hematology (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Postdoctoral Position in Stem Cell Biology/Neuroscience/Cancer (The Jackson Laboratory)

Postdoctoral Fellow in Epigenetic Regulation of Neural Stem Cells (University of Wisconsin-Madison)

Postdoctoral Position in Neuronal Cell Biology (University of Basel)

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