Neural Cell News Volume 6.35 | Sep 5 2012

Calcium Entry Induces Mitochondrial Oxidant Stress in Vagal Neurons at Risk in Parkinson’s Disease
Researchers characterized neurons in the dorsal motor nucleus of the vagus, a population of cholinergic neurons that show signs of pathology in the early stages of Parkinson’s disease, in mouse brain slices. [Nat Neurosci] Abstract

JNK3 Perpetuates Metabolic Stress Induced by Aβ Peptides
Researchers discovered that JNK3 activation, which is increased in human Alzheimer’s disease (AD) cases and a familial AD mouse model, is integral to perpetuating Aβ42 production. [Neuron] Abstract

Estradiol Promotes Neural Stem Cell Differentiation into Endothelial Lineage and Angiogenesis in Injured Peripheral Nerve
Scientists investigated whether estradiol can promote the therapeutic potential of neural stem cell (NSC) transplantation for injured nerve repair via the differentiation of NSCs into endothelial cells during neovascularization. [Angiogenesis] Abstract

Regulation of Neural Stem Cell Differentiation by Transcription Factors HNF4-1 and MAZ-1
Investigators describe how the transcription factors hepatic nuclear factor (HNF4-1) and myc-associated zinc finger protein (MAZ-1) regulate the expression of Rho-GDP dissociation inhibitor γ in the stimulation of neural stem cell differentiation. [Mol Neurobiol] Abstract

Neuron-Specific Prolyl-4-Hydroxylase Domain 2 Knockout Reduces Brain Injury after Transient Cerebral Ischemia
Scientists investigated the effect of neuronal deletion of prolyl-4-hydroxylase domain 2, the most abundant isoform in brain, for stroke outcome. [Stroke] Abstract

Efficient Expansion and Dopaminergic Differentiation of Human Fetal Ventral Midbrain Neural Stem Cells by Midbrain Morphogens
Investigators present a method for generating large numbers of midbrain dopaminergic neurons based on expanding and differentiating neural stem/progenitor cells present in the human ventral midbrain tissue. [Neurobiol Dis] Abstract

Elevating SOX2 Levels Deleteriously Affects the Growth of Medulloblastoma and Glioblastoma Cells
Researchers report that elevating SOX2 three-fold above endogenous levels in glioblastoma and medulloblastoma cells significantly impairs their ability to proliferate. [PLoS One] Ful Article

Directed Differentiation of Embryonic P19 Cells and Neural Stem Cells into Neural Lineage on Conducting Poly(3,4-Ethylenedioxythiophene)-Poly(Ethylene Glycol) and Indium Glass Substrates
Differentiation of pluripotent and lineage restricted stem cells such as neural stem cells were studied on conducting substrates of various nature without perturbation of the genome with exogenous genetic material or chemical stimuli. [Arch Biochem Biophys] Full Article

Targeting Glioma Stem Cells by Functional Inhibition of a Prosurvival OncomiR-138 in Malignant Gliomas
Investigators report the identification of microRNA-138 (miR-138) as a molecular signature of glioma stem cells and demonstrate a vital role for miR-138 in promoting growth and survival of bona fide tumor-initiating cells with self-renewal potential. [Cell Rep] Abstract | Press Release

StemCells, Inc. Reports Positive Interim Data from Spinal Cord Injury Trial
StemCells, Inc. announced that interim six-month data from the first patient cohort in the company’s phase I/II clinical trial of its proprietary HuCNS-SC® product candidate for chronic spinal cord injury continues to demonstrate a favorable safety profile, and shows considerable gains in sensory function in two of the three patients compared to pre-transplant baselines. [StemCells, Inc.] Press Release

Anne-Marie Duliege Appointed to Governing Board of California’s Stem Cell Agency
Anne-Marie Duliege, MD, Chief Medical Officer of Affymax Inc., has been appointed to the Independent Citizens Oversight Committee, the governing board of California’s stem cell agency, the California Institute for Regenerative Medicine. [California Institute for Regenerative Medicine] Press Release

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW BIT’s 3^rd Annual World Congress of Molecular & Cell Biology
June 14-16, 2013
Suzhou, China

Visit our events page to see a complete list of events in the neural cell community.

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Senior Research Associate – Neural Stem Cell (University College London)

Postdoctoral Position – Genetics of Zebrafish Neural Circuits (Uni Research AS, Sars Centre)

Postdoctoral Position – Adult Neural Stem Cell Research (Cleveland Clinic)

Postdoctoral Position – Neuro-Glia Interactions (University Clinic Bonn)

Postdoctoral Position – Neurodegeneration Molecular Cell Biology (Mount Sinai School of Medicine)

Postdoctoral Position – Neurobiology (Weizmann Institute of Science)

Postdoctoral Position – Neural Stem Cell (University of Wisconsin)

Postdoctoral Position – Pathophysiology of Brain Tumors (UMR 6301 ISTCT)

Research Associate – Quality Assurance (University of California)

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