| PUBLICATIONS (Ranked by impact factor of the journal) | Inhibition of ASK1-p38 Pathway Prevents Neural Cell Death following Optic Nerve Injury The authors found that optic nerve injury (ONI)-induced p38 activation and retinal ganglion cell loss were suppressed in apoptosis signal-regulating kinase 1 (ASK1)-deficient mice. These results suggest that ASK1 activation in both neural and glial cells is involved in neural cell death, and that pharmacological interruption of ASK1-p38 pathways could be beneficial in the treatment of ONI. [Cell Death Differ] Abstract Corelease of Dopamine and GABA by a Retinal Dopaminergic Neuron By combining recordings of dopamine (DA) and GABA release from isolated, genetically identified perikarya of retinal dopaminergic cells from the mouse retina, scientists observed that a proportion of the events of DA and GABA exocytosis were simultaneous, suggesting corelease. [J Neurosci] Abstract Pinocembrin Protects against Beta-Amyloid-Induced Toxicity in Neurons through Inhibiting Receptor for Advanced Glycation End Oroducts (RAGE)-Independent Signaling Pathways and Regulating Mitochondrion-Mediated Apoptosis It is known that amyloid-beta peptide (Abeta) plays a pivotal role in the pathogenesis of Alzheimer’s disease. Interaction between Abeta and RAGE has been implicated in neuronal degeneration associated with this disease. Researchers investigated the effects of pinocembrin on the cognitive function and neuronal protection against Abeta-induced toxicity and explored its potential mechanism. [BMC Med] Abstract | Full Article Time Limited Immunomodulatory Functions of Transplanted Neural Precursor Cells Researchers studied time-associated changes in neural stem/precursor cell (NPC) immunomodulatory properties. They examined whether intracerebrally-transplanted NPCs are able to inhibit early versus delayed induction of autoimmune brain inflammation and whether allogeneic NPC grafts continuously inhibit host rejection responses. [Glia] Abstract Phosphatidylcholine-Specific Phospholipase C/Heat Shock Protein 70 (Hsp70)/Transcription Factor B-Cell Translocation Gene 2 Signaling in Rat Bone Marrow Stromal Cell Differentiation to Cholinergic Neuron-Like Cells Investigators found that functional suppression of Hsp70 blocked D609 increased B-cell translocation gene 2 (Btg2) expression and cholinergic neuronal differentiation of bone marrow stromal cells (BMSCs). These results demonstrated that Hsp70 was the pivotal factor in phosphatidylcholine-specific phospholipase C-medicated neuronal differentiation of BMSCs, and Btg2 might be its downstream target. [Int J Biochem Cell Biol] Abstract Skeletal Muscle Neural Progenitor Cells Exhibit Properties of NG2-Glia Scientists showed that Nestin-GFP+ progenitor cells share morphological and molecular markers with NG2-glia and A2B5 expression. Although these cells exhibit NG2, they do not express other pericyte markers, such as α-SMA or connexin-43, and do not differentiate into the muscle lineage. [Exp Cell Res] Abstract Nestin-Expressing Cells in the Gut Give Rise to Enteric Neurons and Glial Cells Investigators aimed to isolate and characterize mucosa-derived neuronal stem cells, determine their relationship to Nestin-expressing cells and to demonstrate their capacity to produce neuroglial networks in vitro and in vivo. [Neurogastroenterol Motil] Abstract Exendin-4 Improved Rat Cortical Neuron Survival Under Oxygen/Glucose Deprivation through PKA Pathway The authors indicated that Exendin-4 protected neurons against oxygen/glucose deprivation by modulating the unfolded protein response through PKA pathway and may serve as a novel therapeutic agent for stroke. [Neuroscience] Abstract Cul4B Regulates Neural Progenitor Cell Growth Scientists provide evidence that unneddylated cullin-4b (Cul4B) isoforms exist in the brain and are necessary for mitosis progression in neural progenitor cells. The data suggests that unneddylated Cul4B isoforms specifically inhibits beta-catenin degradation during mitosis. [BMC Neurosci] Abstract | Full Article Neural Progenitor Cells Derived from Adult Bone Marrow Mesenchymal Stem Cells Promote Neuronal Regeneration The authors investigated whether bone marrow mesenchymal stem cell (BMSC) derived neural progenitor cells (MDNPCs) can promote in vitro neural regeneration, a process comprising mainly the generation of neurons and neurotransmitters. They co-cultured BMSC, MDNPC or fetal neural stem/progenitor cells with PC12 cells and studied their roles on proliferation, neurite formation and dopamine release from PC12 cells. [Life Sci] Abstract |
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