| PUBLICATIONS (Ranked by impact factor of the journal) | Dedifferentiation of Neurons and Astrocytes by Oncogenes Can Induce Gliomas in Mice Investigators showed that gliomas can originate from differentiated cells in the central nervous system, including cortical neurons. Transduction by oncogenic lentiviral vectors of neural stem cells, astrocytes, or even mature neurons in the brain of mice can give rise to malignant gliomas. [Science] Abstract | Press Release Neural Progenitor Cells Regulate Microglia Functions and Activity Scientists found mouse neural progenitor cells to have a secretory protein profile distinct from other brain cells and to modulate microglial activation, proliferation and phagocytosis. [Nat Neurosci] Abstract | Press Release Isolation of Multipotent Neural Stem or Progenitor Cells from Both the Dentate Gyrus and Subventricular Zone of a Single Adult Mouse The authors described a protocol to isolate self-renewing and multipotent neural stem or progenitor cells from the subventricular zone and the dentate gyrus of the same adult mouse. [Nat Protoc] Abstract | Full Article Temporal Application of Topography to Increase the Rate of Neural Differentiation from Human Pluripotent Stem Cells Researchers explored the effect of topography on the neural differentiation of human pluripotent stem cells by quantitatively studying the changes in marker expression at a transcript and protein level. [Biomaterials] Abstract Direct Isolation and RNA-Sequencing Reveal Environment-Dependent Properties of Engrafted Neural Stem/Progenitor Cells Investigators combined bioimaging, flow-cytometric isolation and ultra-high-throughput RNA sequencing to evaluate the cellular properties of engrafted neural stem/progenitor cells (NSPCs). The acutely transplanted NSPCs had beneficial effects on spinal cord injury, particularly neuroprotection and neurohumoral secretion, whereas their in situ secretory activity differed significantly from that predicted in vitro. [Nat Commun] Abstract An In Vitro Model of Developmental Synaptogenesis Using Co-Cultures of Human Neural Progenitors and Cochlear Explants To successfully replace auditory neurons, stem cell-derived neurons must be electrically active, capable of organized outgrowth of processes, and of making functional connections with appropriate tissues. Researchers developed an in vitro assay to test these parameters using co-cultures of developing cochlear explants together with neural progenitors derived from human embryonic stem cells. [Stem Cells Dev] Abstract Effects of Salvianolic Acid B on Survival, Self-Renewal and Neuronal Differentiation of Bone Marrow Derived Neural Stem Cells Scientists demonstrated that salvianolic acid B possesses the ability to promote bone marrow derived-neural stem cells proliferation in a dose dependent manner as verified by growth curve and bromodeoxyuridine incorporation assays. [Eur J Pharmacol] Abstract Transplantation of Neural Stem Cells Co-Transfected with Nurr1 and Brn4 for Treatment of Parkinsonian Rats The authors investigated the effect of transplanted neural stem cells (NSCs) in Parkinson’s disease (PD) model rats. Results show that overexpression of Nurr1 promoted NSCs to differentiate into dopaminergic neurons in vivo, increased the level of dopamine neurotransmitter in the striatum, resulting in behavioral improvement of PD rats. [Int J Dev Neurosci] Abstract Interferon-β Delivery via Human Neural Stem Cell Abates Glial Scar Formation in Spinal Cord Injury Glial scar formation is the major impedance to axonal regrowth after spinal cord injury (SCI), and scar-modulating treatments have become a leading therapeutic goal for SCI treatment. Here, human neural stem cells encoding interferon-β gene were administered intravenously to mice one week after SCI. [Cell Transplant] Abstract | Full Article |
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