Neuronal Nogo-A Negatively Regulates Dendritic Morphology and Synaptic Transmission in the Cerebellum Researchers used general genetic ablation as well as selective overexpression of Nogo-A in Purkinje cells to analyze its effect on dendritogenesis and on the formation of their main input synapses from parallel and climbing fibers. [Proc Natl Acad Sci USA] Abstract Increased Neuronal Activity Fragments the Golgi Complex Investigators observed reversible fragmentation of the Golgi complex in cultured hippocampal neurons cultured in hyperexcitable conditions. In addition, Golgi fragmentation was found in cultured neurons with hyperactivity due to prolonged blockade of GABAA-mediated inhibition or withdrawal of NMDA receptor antagonism. [Proc Natl Acad Sci USA] Abstract Fluoxetine-Induced Cortical Adult Neurogenesis Researchers showed that chronic treatment with a selective serotonin reuptake inhibitor, fluoxetine, stimulated the neurogenesis of gamma-aminobutyric acid (GABA)ergic interneurons from layer 1 inhibitory neuron progenitor cells in the cortex of adult mice. [Neuropsychopharmacol] Full Article The Angelman Syndrome Protein Ube3a Is Required for Polarized Dendrite Morphogenesis in Pyramidal Neurons Scientists report that the Angelman syndrome protein ubiquitin-protein ligase E3A plays an important role in specifying the polarization of pyramidal neuron dendritic arbors in mice. [J Neurosci] Abstract | Press Release FoxP2 Regulates Neurogenesis during Embryonic Cortical Development Researchers provide evidence that FoxP2 regulates genesis of some intermediate progenitors and neurons in the mammalian cortex, one of the key centers for human speech. [J Neurosci] Abstract Reprogramming Amacrine and Photoreceptor Progenitors into Retinal Ganglion Cells by Replacing Neurod1 with Atoh7 Investigators showed that Neurod1-expressing retina progenitor cells (RPCs), which are destined to produce amacrine and photoreceptor cells, can be re-programmed into retinal ganglion cells (RGCs) when Atoh7 is inserted into the Neurod1 locus. These results suggest that Atoh7 acts dominantly to convert a RPC subpopulation not destined for an RGC fate to adopt that fate. [Development] Abstract Neural Development Is Dependent on the Function of Specificity Protein 2 in Cell Cycle Progression Scientists demonstrated that neural stem cells and intermediate neural progenitor cells employ a zinc-finger transcription factor specificity protein 2 as a cell cycle regulator in two temporally and spatially distinct progenitor domains. [Development] Abstract A Global Transcriptome Analysis Reveals Molecular Hallmarks of Neural Stem Cell Death, Survival, and Differentiation in Response to Partial FGF-2 and EGF Deprivation Using cultures of embryonic and adult olfactory bulb stem cells, scientists analyzed the consequences of fibroblast growth factor-2 and epidermal growth factor addition at different intervals on proliferation, cell cycle progression, cell death and differentiation, as well as on global gene expression. [PLoS One] Full Article Neuregulin Facilitates Nerve Regeneration by Speeding Schwann Cell Migration via ErbB2/3-Dependent FAK Pathway Cultured RSC96 cells treated with neuregulin were processed for erbB2/3 immunofluorescence and FAK immunoblottings. The potential effects of neuregulin on schwann cells were assessed by cell adherence, spreading, and migration assays. [PLoS One] Full Article |