Forebrain Engraftment by Human Glial Progenitor Cells Enhances Synaptic Plasticity and Learning in Adult Mice To assess the cell-autonomous and species-selective properties of human glia, scientists engrafted human glial progenitor cells into neonatal immunodeficient mice. Upon maturation, the recipient brains exhibited large numbers and high proportions of both human glial progenitors and astrocytes. [Cell Stem Cell] Full Article | Video Abstract | Press Release Interplay of LRRK2 with Chaperone-Mediated Autophagy Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease. Researchers found LRRK2 to be degraded in lysosomes by chaperone-mediated autophagy, whereas the most common pathogenic mutant form of LRRK2, G2019S, was poorly degraded by this pathway. [Nat Neurosci] Abstract | Press Release Aberrant Schwann Cell Lipid Metabolism Linked to Mitochondrial Deficits Leads to Axon Degeneration and Neuropathy Researchers investigated a mouse model of peripheral neuropathy secondary to Schwann cell (SC) mitochondrial dysfunction. They showed that disruption of SC mitochondria activates a maladaptive integrated stress response through the actions of heme-regulated inhibitor kinase, and causes a shift in lipid metabolism away from fatty acid synthesis toward oxidation. [Neuron] Abstract Transient Treatment with Epigenetic Modifiers Yields Stable Neuroblastoma Stem Cells Resembling Aggressive Large-Cell Neuroblastomas By treating neuroblastoma (NB) cell lines with epigenetic modifiers for a short time, followed by sphere-forming culture conditions, investigators have established stem cell-like NB cells that are phenotypically stable for more than a year. These cells are characterized by their high expression of stemness factors, stem cell markers, and open chromatin structure. [Proc Natl Acad Sci USA] Full Article TLR9 Mediates Cellular Protection by Modulating Energy Metabolism in Cardiomyocytes and Neurons Scientists uncovered an unexpected role of toll-like receptor 9 (TLR9) in energy metabolism and cellular protection in cardiomyocytes and neurons. TLR9 stimulation reduced energy substrates and increased the AMP/ATP ratio, subsequently activating AMP-activated kinase, leading to increased stress tolerance against hypoxia in cardiomyocytes without inducing the canonical inflammatory response. [Proc Natl Acad Sci USA] Full Article A Sympathetic Neuron Autonomous Role for Egr3-Mediated Gene Regulation in Dendrite Morphogenesis and Target Tissue Innervation Scientists showed that Egr3 expression within sympathetic neurons is required for their normal innervation since isolated sympathetic neurons lacking Egr3 have neurite outgrowth abnormalities when treated with nerve growth factor and mice with sympathetic neuron-restricted Egr3 ablation have target tissue innervation abnormalities similar to mice lacking Egr3 in all tissues. [J Neurosci] Abstract Minocycline Selectively Inhibits M1 Polarization of Microglia Researchers used SOD1G93A mice as a model, which exhibit the motor neuron-specific neurodegenerative disease, amyotrophic lateral sclerosis. Administration of minocycline attenuated the induction of the expression of pro-inflammatory (M1) microglia markers during the progressive phase, whereas it did not affect the transient enhancement of expression of anti-inflammatory microglia markers during the early pathogenesis phase. [Cell Death Dis] Full Article Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) Plays a Key Role in Vasculogenic Mimicry Formation, Neovascularization and Tumor Initiation by Glioma Stem-like Cells The authors report a critical role of glioma stem-like cells (GSLCs) in the formation of vasculogenic mimicry (VM), which defines channels lined by tumor cells to supply nutrients to early growing tumors and tumor initiation. GSLCs preferentially expressed VEGFR-2 that upon activation by VEGF, mediated chemotaxis, tubule formation and increased expression of critical VM markers by GSLCs. [PLoS One] Full Article Protection of Neuronal Diversity at the Expense of Neuronal Numbers during Nutrient Restriction in the Drosophila Visual System In the Drosophila visual system, researchers identified two developmental phases with different sensitivities to dietary nutrients. During early larval stages, nutrients regulated the size of the neural progenitor pool via insulin/PI3K/TOR-dependent symmetric neuroepithelial divisions. [Cell Reports] Full Article | Graphical Abstract MiR-134 Regulates the Proliferation and Invasion of Glioblastoma Cells by Reducing Nanog Expression Investigators defined the expression and function of miR-134, which they found to be downregulated in glioma samples and the glioblastoma cell line U87 by SYBR green real-time quantitative reverse transcription-PCR. [Int J Oncol] Abstract | Full Article |