Local Potentiation of Excitatory Synapses by Serotonin and Its Alteration in Rodent Models of Depression Scientists found that endogenous serotonin selectively potentiated excitatory synapses formed by the temporoammonic pathway with CA1 pyramidal cells via activation of serotonin receptors, without affecting nearby Schaffer collateral synapses. [Nat Neurosci] Abstract | Press Release β-Tubulin Mutations that Cause Severe Neuropathies Disrupt Axonal Transport Investigators have analyzed β-tubulin mutations that cause neuronal diseases and they identified mutations that strongly inhibited axonal transport of vesicles and mitochondria. [EMBO J] Abstract SPARC Regulates Microgliosis and Functional Recovery following Cortical Ischemia Investigators report that after photothrombotic stroke in the forelimb sensorimotor cortex, secreted protein acidic rich in cysteine (SPARC) nulls demonstrate enhanced microgliosis in and around the lesion site, which accompanies significantly enhanced functional recovery by 32 days after lesion. Microglia from SPARC nulls also intrinsically proliferate at a greater rate in vitro: an enhanced effect that can be rescued by the addition of exogenous SPARC. [J Neurosci] Abstract Novel HSP90 Inhibitor NVP-HSP990 Targets Cell Cycle Regulators to Ablate Olig2-Positive Glioma Tumor Initiating Cells Investigators evaluated the effects of a novel HSP90 inhibitor, NVP-HSP990, in glioma tumor initiating cell (GIC) populations, which are strongly implicated in the root pathobiology of glioblastoma multiforme. In GIC cultures, NVP-HSP990 elicited a dose-dependent growth inhibition with IC50 values in the low nanomolar range. [Cancer Res] Abstract Developing Rods Transplanted into the Degenerating Retina of Crx-Knockout Mice Exhibit Neural Activity Similar to Native Photoreceptors Researchers described the physiological properties of developing rod photoreceptors that are tagged with GFP driven by the promoter of rod differentiation factor, Nrl. GFP-tagged developing rods show Ca2+ responses and rectifier outward currents that are smaller than those observed in fully developed photoreceptors, suggesting their immature developmental state. [Stem Cells] Abstract Derivation of Sensory Neurons and Neural Crest Stem Cells from Human Neural Progenitor hNP1 The authors report the differentiation of sensory neurons from a human neural progenitor cell line, hNP1, and their functional maturation in a defined, in vitro culture system without murine cell feeder layers. [Biomaterials] Abstract BACE1 and Presenilin/γ-Secretase Regulate Proteolytic Processing of KCNE1 and 2, Auxiliary Subunits of Voltage-Gated Potassium Channels Scientists report that KCNE1 and KCNE2, auxiliary subunits of voltage-gated potassium channels, undergo sequential cleavage mediated by either α-secretase and presenilin (PS)/γ-secretase or BACE1 and PS/γ-secretase in cells. Elevated α-secretase or BACE1 activities increased C-terminal fragment levels of KCNE1 and 2 in human embryonic kidney and rat neuroblastoma cells. [FASEB J] Abstract Calsyntenin-3 C-Terminal Fragment Accumulates in Dystrophic Neurites Surrounding Aβ Plaques in Tg2576 Mouse and Alzheimer Disease Brains: Its Neurotoxic Role in Mediating Dystrophic Neurite Formation Researchers showed that the CTF but not full-length calsyntenin-3 (Cst-3) accumulated in dystrophic neurites surrounding β-amyloid (Aβ) plaques in Tg2576 mouse and Alzheimer disease-affected brain. In vitro experiments with Cst-3 fragments revealed that only the CTF resulted in acceleration of neuronal death. [Am J Pathol] Abstract Induced Pluripotent Stem Cell-Derived Neural Cells Survive and Mature in the Nonhuman Primate Brain Investigators showed that transplanted autologous rhesus monkey induced pluripotent stem cell-derived neural progenitors survive for up to six months and differentiate into neurons, astrocytes, and myelinating oligodendrocytes in the brains of MPTP-induced hemiparkinsonian rhesus monkeys with a minimal presence of inflammatory cells and reactive glia. [Cell Rep] Abstract | Graphical Abstract | Press Release Deriving Dopaminergic Neurons for Clinical Use. A Practical Approach New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. [Sci Rep] Full Article | Press Release |