Pharmacologic Inhibition of Histone Demethylation as a Therapy for Pediatric Brainstem Glioma Investigators show that GSKJ4 pharmacologic inhibition of K27 demethylase JMJD3 increases cellular H3K27 methylation in K27M tumor cells and demonstrate potent antitumor activity both in vitro against K27M cells and in vivo against K27M xenografts. [Nat Med] Abstract | Press Release Tgfβ Signaling Regulates Temporal Neurogenesis and Potency of Neural Stem Cells in the CNS By examining a temporal differentiation lineage in the hindbrain, researchers identified Tgfβ as a switch signal that executes the transition between early and late phases of neurogenesis and concurrently constrains progenitor potency. [Neuron] Abstract | Press Release VTA CRF Neurons Mediate the Aversive Effects of Nicotine Withdrawal and Promote Intake Escalation Scientists identify in rodents and humans a population of ventral tegmental area (VTA) dopaminergic neurons expressing corticotropin-releasing factor (CRF). They provide evidence in rodents that chronic nicotine exposure upregulates Crh mRNA in dopaminergic neurons of the posterior VTA, activates local CRF1 receptors and blocks nicotine-induced activation of transient GABAergic input to dopaminergic neurons. [Nat Neurosci] Abstract | Press Release The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model In an attempt to improve treatment outcome, researchers investigated the effect of Δ9-tetrahydrocannabinol and cannabidiol both alone and in combination with radiotherapy in a number of glioma cell lines. [Mol Cancer Ther] Abstract | Press Release Evaluation of Motor Neuron-Like Cell Differentiation of hEnSCs on Biodegradable PLGA Nanofiber Scaffolds Scientists investigated the capability of human endometrial stem cells (hEnSCs) to be differentiated into motor neuron-like cells under biochemical and topographical cues. [Mol Neurobiol] Abstract Disruption of Polyubiquitin Gene Ubb Causes Dysregulation of Neural Stem Cell Differentiation with Premature Gliogenesis To determine whether or not the defects in neurons or their progenitors, but not in their cellular microenvironment, are the cause of the neural phenotypes observed in Ubb−/− mice, the authors investigated the properties of cultured cells isolated from Ubb−/− mouse embryonic brains. [Sci Rep] Full Article A Targeted Secretome Profiling by Multiplexed Immunoassay Revealed that Secreted Chemokine Ligand 2 (MCP-1/CCL2) Affects Neural Differentiation in Mesencephalic Neural Progenitor Cells By exploiting the multiplexing capability of magnetic beads-based immunoassays, researchers investigated the changes of the expression levels of a set of chemokines and cytokines released from the pluripotent neural cell line mes-c-myc A following its differentiation from a proliferating toward a neural phenotype. [Proteomics] Abstract Glioblastoma Exosomes and IGF-1R/AS-ODN Are Immunogenic Stimuli in a Translational Research Immunotherapy Paradigm In a pilot study, a vaccine consisting of Lucite diffusion chambers containing irradiated autologous tumor cells pre-treated with an antisense oligodeoxynucleotide directed against the insulin-like growth factor type 1 receptor was found to elicit positive clinical responses in 8/12 patients when implanted in the rectus sheath for 24 hours. Investigators make use of a murine glioma model and samples from glioblastoma patients in this second Phase I trial to investigate this novel therapeutic intervention more thoroughly. [Cancer Immunol Immunother] Abstract | Press Release Hypoxic Conditioned Medium from Rat Cerebral Cortical Cells Enhances the Proliferation and Differentiation of Neural Stem Cells Mainly through PI3-K/Akt Pathways Scientists investigated the effects of hypoxic conditioned media from rat cerebral cortical cells on the proliferation and differentiation of neural stem cells in vitro, and studied the roles of PI3-K/Akt and JNK signal transduction pathways in these processes. [PLoS One] Full Article |