A Coding-Independent Function of an Alternative Ube3a Transcript during Neuronal Development Scientists report that Ube3a1 RNA, a transcript that encodes a truncated Ube3a protein lacking catalytic activity, prevents exuberant dendrite growth and promotes spine maturation in rat hippocampal neurons. [Nat Neurosci] Abstract Foxp1-Mediated Programming of Limb-Innervating Motor Neurons from Mouse and Human Embryonic Stem Cells Scientists demonstrated that limb-innervating lateral motor column motor neurons can be efficiently generated from mouse and human embryonic stem cells through manipulation of the transcription factor Foxp1. [Nat Commun] Full Article Neuronal Medium that Supports Basic Synaptic Functions and Activity of Human Neurons In Vitro The authors examined neuronal activity in media widely used to culture neurons. They found that classic basal media, as well as serum, impair action potential generation and synaptic communication. To overcome this problem, they designed a new neuronal medium in which we adjusted the concentrations of inorganic salts, neuroactive amino acids, and energetic substrates. [Proc Natl Acad Sci USA] Abstract | Full Article Human iPSC-Derived Neural Progenitors Preserve Vision in an AMD-Like Model The authors demonstrated that transplantation of neural progenitor cells derived from induced pluripotent stem cells (iNPCs) limits disease progression in the Royal College of Surgeons rat, a preclinical model of age-related macular degeneration (AMD). [Stem Cells] Abstract Synergistic Action of Dendritic Mitochondria and Creatine Kinase Maintains ATP Homeostasis and Actin Dynamics in Growing Neuronal Dendrites Scientists studied mitochondrial distribution within developing mouse cerebellar Purkinje cells and found that active delivery of mitochondria into their dendrites is a prerequisite for proper dendritic outgrowth. [J Neurosci] Abstract | Press Release Galectin-1-Secreting Neural Stem Cells Elicit Long-Term Neuroprotection against Ischemic Brain Injury Scientists investigated transplantation of galectin-1 (gal-1)-secreting neural stem cell into ischemic brains and identified the mechanisms underlying protection. To accomplish this goal, secretory gal-1 was stably overexpressed in NE-4C neural stem cells. [Sci Rep] Full Article Thyroid Hormone-Otx2 Signaling Is Required for Embryonic Ventral Midbrain Neural Stem Cells Differentiated into Dopamine Neurons Researchers provide both in vivo and in vitro evidence that thyroid hormone, an important physiological factor for brain development, promotes dopamine neuron differentiation from embryonic ventral midbrain neuronal stem cells. [Stem Cells Dev] Abstract Milk Fat Globule-EGF Factor VIII Attenuates CNS Injury by Promoting Neural Stem Cell Proliferation and Migration after Cerebral Ischemia Scientists report that the treatment of recombinant human milk fat globule-EGF Factor VIII (MFG-E8) significantly improved the neurological deficit score, body weight lost and neural stem cell proliferation in a rat model of transient middle cerebral artery occlusion (tMCAO). Conversely, decreased neural stem cell proliferation was observed in Mfge8-/- mice in comparison with the wild-type counterparts underwent tMCAO. [PLoS One] Full Article Protective Effects and Mechanisms of Salvianolic Acid B Against H2O2-Induced Injury in Induced Pluripotent Stem Cell-Derived Neural Stem Cells Investigators explored the potential mechanism of salvianolic acid B (Sal B) in protecting induced pluripotent stem cells (iPSC)-derived neural stem cells (NSCs) against H2O2-induced injury. iPSCs were induced into NSCs, iPSC-derived NSCs were treated with 50 μM Sal B for 24.5 hours and 500 μM H2O2 for 24 hours. [Neurochem Res] Abstract Ex Vivo Gene Therapy Using Patient iPSC-Derived NSCs Reverses Pathology in the Brain of a Homologous Mouse Model Investigators evaluated a complete process of ex vivo gene therapy using human induced pluripotent stem cell (iPSC)-derived neural stem cell (NSC) transplants in a well-characterized mouse model of a human lysosomal storage disease, Sly disease. [Stem Cell Rep] Full Article | Graphical Abstract |