Live Imaging of Adult Neural Stem Cell Behavior in the Intact and Injured Zebrafish Brain Investigators used repetitive imaging to follow single stem cells in the intact and injured adult zebrafish telencephalon in vivo and found that neurons are generated by both direct conversions of stem cells into postmitotic neurons and via intermediate progenitors amplifying the neuronal output. [Science] Abstract Presenilin 1 Is Necessary for Neuronal, but Not Glial, EGFR Expression and Neuroprotection via γ-Secretase-Independent Transcriptional Mechanisms Researchers showed that absence of presenilin 1 (PS1) results in dramatic decrease of neuronal epidermal growth factor receptor (EGFR) and that PS1-null (PS1−/−) brains have reduced amounts of this receptor. PS1−/− cortical neurons contained little EGFR and showed no epidermal growth factor-induced survival signaling or protection against excitotoxicity, but exogenous EGFR rescued both functions even in absence of PS1. [FASEB J] Abstract E-Cadherin Enhances Neuregulin Signaling and Promotes Schwann Cell Myelination To determine whether E-cadherin plays a regulatory role during Schwann cell myelination, the authors investigated the effects of E-cadherin deletion and over-expression in Schwann cells. [Glia] Abstract Oncostatin M-Dependent Mcl-1 Induction Mediated by JAK1/2-STAT1/3 and CREB Contributes to Bioenergetic Improvements and Protective Effects against Mitochondrial Dysfunction in Cortical Neurons Scientists tested the hypothesis that oncostatin M (OSM) may confer neuronal resistance against 3-nitropropionic acid (3-NP), a plant toxin that irreversibly inhibits the complex II of the mitochondrial electron transport chain, and characterized the underlying molecular mechanisms. They found that OSM preconditioning dose- and time-dependently protected cortical neurons against 3-NP toxicity. [Biochim Biophys Acta] Abstract Prevention of Human Dopaminergic Neurodegeneration in an Astrocytes Co-Culture System allowing Endogenous Drug Metabolism Researchers grew an intricate network of human dopaminergic neurons on top of a dense layer of astrocytes. In these co-cultures, 1-methyl-4-phenyl-tetrahydropyridine was metabolized to 1-methyl-4-phenyl-pyridinium by the glial cells, and the toxic metabolite was taken up through the dopamine transporter into neurons. [Br J Pharmacol] Abstract Psora-4, a Kv1.3 Blocker, Enhances Differentiation and Maturation in Neural Progenitor Cells A small-molecule selective blocker for Kv1.3, Psora-4, was added to the differentiation medium of cultured mouse neural progenitor cells (NPCs) to assess its effect on NPC differentiation efficiency. [CNS Neurosci Ther] Abstract Ezh2 Maintains Retinal Progenitor Proliferation, Transcriptional Integrity, and the Timing of Late Differentiation Scientists showed that during retinal development in mouse, there are dynamic patterns of expression of the polycomb repressive complex 2 catalytic subunit EZH2 in retinal progenitors and some differentiated cells, as well as dynamic changes in the histone modification H3K27me3. [Dev Biol] Abstract Altered Proliferative Ability of Neuronal Progenitors in PlexinA1 Mutant Mice Earlier studies have highlighted the importance of neuropilin 1 (Nrp1) and Nrp2 in interneuron migration, therefore scientists assessed the role of PlexinA1 in this process. They observed significantly fewer cells expressing the interneuron markers Gad67 and Lhx6 in the cortex of PlexinA1-/- mice compared to wild-type littermates at E14.5 and E18.5. [J Comp Neurol] Abstract Plexin-B3 Suppresses Excitatory and Promotes Inhibitory Synapse Formation in Rat Hippocampal Neurons Researchers demonstrated that Plexin-B2 and Plexin-B3 are present in dendrites, but do not localize in synapses. They found that overexpression of all B-plexins leads to decreased volume of excitatory synapses, and at the same time Plexin-B1 and Plexin-B3 promote inhibitory synapse assembly. [Exp Cell Res] Abstract Glucagon-Like Peptide-1 Regulates Mitochondrial Biogenesis and Tau Phosphorylation against Advanced Glycation End Product-Induced Neuronal Insult: Studies In Vivo and In Vitro Investigators demonstrated glucagon-like peptide-1 receptor agonists could inhibit oxidative stress and repair the mitochondrial damage in addition to decreasing tau hyperphosphorylation in PC12 cells treated with advanced glycation end products. [Neuroscience] Abstract Let7a Involves in Neural Stem Cell Differentiation Relating with TLX Level The authors investigated whether microRNA-Let7a (Let7a) regulates neural stem cell (NSC) differentiation by targeting the nuclear receptor TLX, which is an essential regulator of NSC self-renewal, proliferation and differentiation. [Biochem Biophys Res Commun] Abstract |