Rapid Conversion of Fibroblasts into Functional Forebrain GABAergic Interneurons by Direct Genetic Reprogramming Investigators identified five factors that convert mouse fibroblasts into induced GABAergic interneurons (INs) possessing molecular signatures of telencephalic INs. [Cell Stem Cell] Abstract | Graphical Abstract Latent Tri-Lineage Potential of Adult Hippocampal Neural Stem Cells Revealed by Nf1 Inactivation In mice, scientists found that inactivation of neurofibromin 1 (Nf1), a gene mutated in neurofibromatosis type 1, unlocked a latent oligodendrocyte lineage potential to produce all three lineages from neural stem cells in vivo. [Nat Neurosci] Abstract MiR-375 Is Essential for Human Spinal Motor Neuron Development and may Be Involved in Motor Neuron Degeneration The authors used neural differentiation of Rest-null mouse ESC to identify dozens of microRNAs regulated by REST during neural development. One of the identified microRNAs, miR-375, was upregulated during human spinal motor neuron development. [Stem Cells] Abstract Subcutaneous Transplantation of Neural Precursor Cells in Experimental Autoimmune Encephalomyelitis Reduces Chemotactic Signals in the Central Nervous System Scientists explored whether the effect of neural precursor cell transplantation on the clinical course and the pathological features of experimental autoimmune encephalomyelitis is combined with the modulation of chemokines levels expressed in the inflamed central nervous system. [Stem Cells Transl Med] Abstract Dynamin-Related Protein 1 Controls the Migration and Neuronal Differentiation of Subventricular Zone-Derived Neural Progenitor Cells Researchers observed that mitochondria were preferentially localized at the leading process of migratory adult neural stem cells, whereas neuronal differentiating cells transiently exhibited perinuclear condensation of mitochondria. [Sci Rep] Full Article Cell Division Mode Change Mediates the Regulation of Cerebellar Granule Neurogenesis Controlled by the Sonic Hedgehog Signaling Using time-lapse imaging and cell culture from neuronal progenitor-specific and differentiated neuron-specific reporter mouse lines and Patched+/− mice in which sonic hedgehog signaling is activated, scientists found evidence for the existence of symmetric and asymmetric divisions that are closely associated with progenitor proliferation and differentiation. [Stem Cell Reports] Full Article Neural Stem Cell Transplantation Decreases Neuroinflammation in a Transgenic Mouse Model of Alzheimer’s Disease Scientists injected neural stem cells into amyloid precursor protein/PS1 transgenic mice to analyze cognitive function and to measure glial fibrillary acidic protein, ionized calcium binding adaptor molecule-1 and toll-like receptors 4 activation. [J Neurochem] Abstract Subcellular Localization of Matrin 3 Containing Mutations Associated with ALS and Distal Myopathy The authors used transient transfection of cultured cell lines to examine the impact of different disease-causing mutations on the localization of Matrin 3 within cells. Using CHO and human H4 neuroglioma cell models, they found that amyotrophic lateral sclerosis (ALS)/myopathy mutations do not produce profound changes in the localization of the protein. [PLoS One] Full Article Different Tissue-Derived Stem Cells: A Comparison of Neural Differentiation Capability Researchers evaluated the neural differentiation capability of different tissue-derived stem cells coming from different tissue sources such as bone marrow, umbilical cord blood, human endometrium and amniotic fluid, cultured under the same supplemented media neuro-transcription factor conditions. [PLoS One] Full Article Minocycline Mitigates the Gliogenic Effects of Proinflammatory Cytokines on Neural Stem Cells The authors investigated the direct effects of minocycline and of proinflammatory cytokines on the differentiation potential of neural stem cells (NSCs) in vitro and in vivo. Primary fetal rat NSCs were treated with minocycline plus a combination of the proinflammatory cytokines tumor necrosis factor-α, interleukin 1β, and interleukin 6. [J Neurosci Res] Abstract |