 | | Vol. 14.24 – 24 June, 2020 |
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| Investigators report an efficient one-step conversion of isolated mouse and human astrocytes to functional neurons by depleting the RNA-binding protein PTB.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed in xenograft models that targeting diacylglycerol-acyltransferase 1 blocked lipid droplet formation, induced tumor cell apoptosis, and markedly suppressed glioblastoma growth.
[Cell Metabolism] |
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| Elevating prominin-1 levels in cultured dorsal root ganglion neurons or in mice via adeno-associated virus-mediated gene delivery enhanced axon regeneration in vitro and in vivo, allowing outgrowth on an inhibitory substrate.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators demonstrated a striatal-specific requirement of transcriptional regulator Nolz1 in establishing dopaminergic circuitry formation.
[Nature Communications] |
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| Researchers recorded basal forebrain cholinergic neurons in vivo, to examine their behavioral functions, and in vitro, to study their intrinsic properties.
[Nature Neuroscience] |
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| Scientists introduced an integration-coupled On genetic switch, iOn, which triggered gene expression upon incorporation into the host genome through transposition, thus enabling rapid and accurate identification of integration events following transfection with naked plasmids.
[Neuron] |
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| Transplanted skin-derived precursors differentiated into Schwann cells (SCs) filled much of the lesion sites and greatly enhanced the presence of endogenous SCs, which myelinated thousands of sprouting/spared host axons in and around the injury site.
[Stem Cell Reports] |
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| Scientists generated human iPSC-derived neurons exhibiting spontaneous oscillatory activity after cultivation of up to six months, which resembled early oscillations observed in rodent neurons. This behavior was found in neurons generated using a more “native” embryoid body protocol, in contrast to a “fast” protocol based on neurogenin 2 overexpression.
[Stem Cell Reports] |
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| PARK2 knockout neurons exhibited a perturbed lysosomal morphology with enlarged electron-lucent lysosomes and an increased lysosomal content, which was exacerbated by mitochondrial stress and could be ameliorated by antioxidant treatment.
[Scientific Reports] |
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| The authors present an overview of recent studies on the developmental origins, migratory properties, and morphology of chandelier cells.
[Trends in Neurosciences] |
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| Mitochon Pharmaceuticals announced that they, in partnership with the University of Kentucky and Children’s Hospital of Philadelphia, were awarded a $3.2M National Institutes of Health grant to study Mitochon’s mitochondrial targeted drug therapies for treating traumatic brain injury.
[Mitochon Pharmaceuticals] |
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| Foundations that fund biomedical research in the United States, the United Kingdom, and elsewhere are reporting record revenue drops because of the pandemic. One major factor: It has forced them to cancel key fundraising events, including glitzy galas, sponsored walks, Broadway partnerships, and more.
[ScienceInsider] |
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| 2020-07-16 – 2020-07-16
Virtual |
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| | Sup’Biotech Engineering School – Villejuif, Lyon, France |
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| | Simon Fraser University – Burnaby, British Columbia, Canada |
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| | F. Hoffmann-La Roche AG – Basel, Switzerland |
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| NIH National Institute of Mental Health – Bethesda, Maryland, United States |
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| Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States |
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