Organoid News Volume 1.02 | July 23 2020

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    ON 1.02 | July 23 2020


    Organoid News by STEMCELL Technologies
    Vol. 1.02 – 23 July, 2020
    TOP STORY

    Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium

    Neuregulin 1 robustly stimulated proliferation in crypts and induced budding in organoids, in part through elevated and sustained activation of mitogen-activated protein kinase and AKT.
    [Cell Stem Cell]

    Abstract

    976e943d-80d4-45d7-8db5-fd26aff29697_ON911-Virtual_Conference_Exhibit-728_x_90-org-1
    PUBLICATIONSRanked by the impact factor of the journal

    Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells upon Endoplasmic Reticulum Stress

    Scientists studied the pathways that regulate activating transcription factor 6 and its role for inflammation in intestinal epithelial cells.
    [Gastroenterology]

    Abstract

    Regulated IFN Signaling Preserves the Stemness of Intestinal Stem Cells by Restricting Differentiation into Secretory-Cell Lineages

    Researchers describe a transcriptional regulator that preserved the stemness of intestinal stem cells by restricting their differentiation into secretory-cell lineages.
    [Nature Cell Biology]

    Abstract

    Comparative Analysis of Cell Lineage Differentiation during Hepatogenesis in Humans and Mice at the Single-Cell Transcriptome Level

    Investigators performed single-cell RNA sequencing of whole human and mouse fetal livers throughout development. They identified four cell lineage families of endoderm-derived, erythroid, non-erythroid hematopoietic, and mesoderm-derived non-hematopoietic cells, and defined the developmental pathways of the major cell lineage families.
    [Cell Research]

    Full Article

    Organotypic Culture Assays for Murine and Human Primary and Metastatic-Site Tumors

    Researchers provided detailed protocols to isolate and culture heterogenous organoids from murine and human primary and metastatic site tumors.
    [Nature Protocols]

    Abstract

    Bile Acids Regulate Intestinal Antigen Presentation and Reduce Graft-versus-Host Disease without Impairing the Graft-versus-Leukemia Effect

    Scientists observed that application of bile acids decreased cytokine-induced cell death in intestinal organoids and cell lines.
    [Haematologica]

    Abstract

    Axonal Extensions along Corticospinal Tracts from Transplanted Human Cerebral Organoids

    Investigators transplanted human embryonic stem cell-derived cerebral organoids at six or ten weeks after differentiation into mouse cerebral cortices.
    [Stem Cell Reports]

    Full Article

    Basal-Like and Classical Cells Coexist in Pancreatic Cancer Revealed by Single-Cell Analysis on Biopsy-Derived Pancreatic Cancer Organoids from the Classical Subtype

    The authors performed single‐cell transcriptomic analyses using combinational barcoding exclusively on epithelial cells from six different classical pancreatic ductal adenocarcinoma patients obtained by Endoscopic Ultrasound with Fine Needle Aspiration.
    [FASEB Journal]

    Full Article

    Neurodevelopmental Impairment Induced by Prenatal Valproic Acid Exposure Shown With the Human Cortical Organoid-on-a-Chip Model

    Investigators indicated the effects of valproic acid on brain development at early stages using engineered cortical organoids from human induced pluripotent stem cells.
    [Microsystems & Nanoengineering]

    Full Article

    AXL Is a Potential Target for the Treatment of Intestinal Fibrosis

    This study demonstrated that inhibition of AXL signaling with the small molecule inhibitor BGB324 abrogated both matrix-stiffness and transforming growth factor beta–induced fibrogenesis in human colonic myofibroblasts.
    [Inflammatory Bowel Diseases]

    Abstract

    Characterization of Multicellular Breast Tumor Spheroids using Image Data-Driven Biophysical Mathematical Modeling

    Using MDA-MB-231 breast cancer multicellular tumor spheroids, researchers estimated biophysical parameters of cellular diffusion, rate of cellular proliferation, and cellular tractions forces.
    [Scientific Reports]

    Full Article

    c05ffec3-0376-4188-a11f-7f377eb6a437_ON837NE-Cerebral-Organoid-Kit-645X110
    REVIEWS

    Modeling Neoplastic Disease with Spheroids and Organoids

    The authors summarize the recent advances in the use of 3D systems for cancer modeling, focusing on their innovative translational applications, looking at future challenges, and comparing them with most widely used animal models.
    [Journal of Hematology & Oncology]

    Full Article

    INDUSTRY AND POLICY NEWS

    Science Money Slashed in EU’s €1.8-Trillion Budget Deal

    A historic €1.8-trillion (US$2.1-trillion) budget deal reached by European Union (EU) leaders to fund its next seven years – and its recovery from the coronavirus pandemic – has left scientists and research advocates disappointed.
    [Nature News]

    Editorial

    The Career Cost of COVID-19 to Female Researchers, and How Science Should Respond

    Early data on the effects of the coronavirus pandemic on scientific-publishing output suggest that female researchers, particularly those at early-career stages, are the hardest hit. Submissions to preprint servers, such as arXiv, rose more quickly for male authors than for female authors as nations adopted social-isolation measures.
    [Nature News]

    Editorial

    ‘Ethically Troubling.’ University Reopening Plans Put Professors, Students on Edge

    Come August, hundreds of universities across the United States are poised to reopen their campuses with a mix of online and in-person courses. Only a handful are aiming for an entirely online semester. But as the machinery of higher education cranks back into action, faculty, staff, and students are voicing concerns that, with COVID-19 cases surging in many parts of the country, employees are being forced to put their health – and the health of others – at unnecessary risk.
    [ScienceInsider]

    Editorial

    FEATURED EVENT

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    JOB OPPORTUNITIES

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    Philipps-Universität Marburg – Marburg, Germany

    Postdoctoral Position – Pluripotent Stem Cell-Derived Human Lung Organoids

    Columbia University Medical Center – New York, New York, United States

    Research Group Leaders – Experimental Neurobiology and Brain Organoids

    Human Technopole Foundation – Milan, Italy

    Research Scientist – CRISPR Technology and Organoids

    Research Center for Molecular Medicine – Vienna, Austria

    CeMM International Postdoctoral Program – Immune-Enriched Organoids

    Research Center for Molecular Medicine – Vienna, Austria

    > See All Jobs

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