| Vol. 1.02 – 23 July, 2020 |
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| Neuregulin 1 robustly stimulated proliferation in crypts and induced budding in organoids, in part through elevated and sustained activation of mitogen-activated protein kinase and AKT. [Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists studied the pathways that regulate activating transcription factor 6 and its role for inflammation in intestinal epithelial cells. [Gastroenterology] |
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| Researchers describe a transcriptional regulator that preserved the stemness of intestinal stem cells by restricting their differentiation into secretory-cell lineages. [Nature Cell Biology] |
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| Investigators performed single-cell RNA sequencing of whole human and mouse fetal livers throughout development. They identified four cell lineage families of endoderm-derived, erythroid, non-erythroid hematopoietic, and mesoderm-derived non-hematopoietic cells, and defined the developmental pathways of the major cell lineage families. [Cell Research] |
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| Researchers provided detailed protocols to isolate and culture heterogenous organoids from murine and human primary and metastatic site tumors. [Nature Protocols] |
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| Scientists observed that application of bile acids decreased cytokine-induced cell death in intestinal organoids and cell lines. [Haematologica] |
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| Investigators transplanted human embryonic stem cell-derived cerebral organoids at six or ten weeks after differentiation into mouse cerebral cortices. [Stem Cell Reports] |
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| The authors performed single‐cell transcriptomic analyses using combinational barcoding exclusively on epithelial cells from six different classical pancreatic ductal adenocarcinoma patients obtained by Endoscopic Ultrasound with Fine Needle Aspiration. [FASEB Journal] |
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| Investigators indicated the effects of valproic acid on brain development at early stages using engineered cortical organoids from human induced pluripotent stem cells. [Microsystems & Nanoengineering] |
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| This study demonstrated that inhibition of AXL signaling with the small molecule inhibitor BGB324 abrogated both matrix-stiffness and transforming growth factor beta–induced fibrogenesis in human colonic myofibroblasts. [Inflammatory Bowel Diseases] |
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| Using MDA-MB-231 breast cancer multicellular tumor spheroids, researchers estimated biophysical parameters of cellular diffusion, rate of cellular proliferation, and cellular tractions forces. [Scientific Reports] |
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| The authors summarize the recent advances in the use of 3D systems for cancer modeling, focusing on their innovative translational applications, looking at future challenges, and comparing them with most widely used animal models. [Journal of Hematology & Oncology] |
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| A historic €1.8-trillion (US$2.1-trillion) budget deal reached by European Union (EU) leaders to fund its next seven years – and its recovery from the coronavirus pandemic – has left scientists and research advocates disappointed. [Nature News] |
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| Early data on the effects of the coronavirus pandemic on scientific-publishing output suggest that female researchers, particularly those at early-career stages, are the hardest hit. Submissions to preprint servers, such as arXiv, rose more quickly for male authors than for female authors as nations adopted social-isolation measures. [Nature News] |
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| Come August, hundreds of universities across the United States are poised to reopen their campuses with a mix of online and in-person courses. Only a handful are aiming for an entirely online semester. But as the machinery of higher education cranks back into action, faculty, staff, and students are voicing concerns that, with COVID-19 cases surging in many parts of the country, employees are being forced to put their health – and the health of others – at unnecessary risk. [ScienceInsider] |
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| October 20 – October 21 Virtual |
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| Philipps-Universität Marburg – Marburg, Germany |
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| Columbia University Medical Center – New York, New York, United States |
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| Human Technopole Foundation – Milan, Italy |
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| Research Center for Molecular Medicine – Vienna, Austria |
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| Research Center for Molecular Medicine – Vienna, Austria |
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