Organoid News Volume 1.03 | July 30 2020

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    ON 1.03 – July 30 2020


    Organoid News by STEMCELL Technologies
    Vol. 1.03 – 30 July, 2020
    TOP STORY

    Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes

    Scientists present a xenotransplantation model of pancreatic ductal adenocarcinoma in which neoplasms originated from patient-derived organoids injected directly into murine pancreatic ducts.
    [Cancer Discovery]

    Full Article


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    PUBLICATIONSRanked by the impact factor of the journal

    Developmental GABA Polarity Switch and Neuronal Plasticity in Bioengineered Neuronal Organoids

    The authors report the directed self-organization of human induced pluripotent stem cells in a collagen hydrogel towards a highly interconnected neuronal network at a macroscale tissue format.
    [Nature Communications]

    Full Article

    Epigenetic Transcriptional Reprogramming by WT1 Mediates a Repair Response during Podocyte Injury

    Using murine models and human kidney organoids, scientists investigated WT1-mediated transcriptional reprogramming during the course of podocyte injury.
    [Science Advances]

    Full Article

    Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential

    The authors report a method to generate ureteric bud organoids that possess epithelial polarity and tubular lumen and repeat branching morphogenesis.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Pharmacogenomics of Aromatase Inhibitors in Postmenopausal Breast Cancer and Additional Mechanisms of Anastrozole Action

    Estrogen receptor positive breast cancer organoids and aromatase inhibitor (AI)- or fulvestrant-resistant breast cancer cells were more sensitive to anastrozole plus estradiol than to AI alone.
    [JCI Insight]

    AbstractGraphical Abstract

    miR-3622a-3p Acts as a Tumor Suppressor in Colorectal Cancer by Reducing Stemness Features and EMT through Targeting Spalt-Like Transcription Factor 4

    The effect of miR-3622a-3p on proliferation, apoptosis, cell cycle, migration and invasion of colorectal cancer (CRC) cells were investigated by a series of biological function assays and the results revealed that miR-3622a-3p could inhibit the malignant biological properties of CRC.
    [Cell Death & Disease]

    Full Article

    Patient-Derived Ovarian Cancer Organoids Capture the Genomic Profiles of Primary Tumors Applicable for Drug Sensitivity and Resistance Testing

    Scientists developed expandable ovarian cancer organoids in less than three weeks; these organoids captured the characteristics of histological cancer subtypes and replicated the mutational landscape of the primary tumors.
    [Scientific Reports]

    Full Article

    Fine-Needle Aspiration-Based Patient-Derived Cancer Organoids

    Researchers present a simple and minimally invasive fine-needle aspiration-based organoid culture technique using a variety of tumor types including gastrointestinal, thyroid, melanoma, and kidney.
    [iScience]

    AbstractGraphical Abstract

    Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening

    Scientists established 12 patient-derived organoids from the most common lung cancer subtype, lung adenocarcinoma. Extensive gene and histopathology profiling showed that the tumor organoids retained the histological architectures, genomic landscapes, and gene expression profiles of their parental tumors.
    [iScience]

    AbstractGraphical Abstract

    New mTeSR™ Plus hPSC Maintenance Medium
    REVIEWS

    3D Brain Organoids: Studying Brain Development and Disease Outside the Embryo

    Scientists consider the biology of brain organoids, compared and contrasted with the endogenous human brain, and highlight experimental strategies to use organoids to pioneer new understanding of human brain pathology.
    [Annual Review of Neuroscience]

    Abstract

    Taming Human Brain Organoids One Cell at a Time

    The authors summarize recent approaches, progresses and challenges in resolving brain organoid’s complexity through single-cell transcriptomics.
    [Seminars in Cell & Developmental Biology]

    Abstract

    INDUSTRY AND POLICY NEWS

    The Trump Administration Must Stop Sidelining the CDC

    As deaths from COVID-19 approach 150,000 in the United States and cases continue to rise alarmingly in many regions of the country, there are strong signs that the government is suppressing a public-health approach to controlling the pandemic.
    [Nature News]

    Editorial

    ‘Vaccine Nationalism’ Threatens Global Plan to Distribute COVID-19 Shots Fairly

    As soon as the first COVID-19 vaccines get approved, a staggering global need will confront limited supplies. Many health experts say it’s clear who should get the first shots: health care workers around the world, then people at a higher risk of severe disease, then those in areas where the disease is spreading rapidly, and finally, the rest of us.
    [ScienceInsider]

    Editorial

    French Science Bill Promises Boost to Public R&D

    The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
    [ScienceInsider]

    Press Release

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    JOB OPPORTUNITIES

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    The Francis Crick Institute – London, United Kingdom

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    Postdoctoral Position – Pluripotent Stem Cell-Derived Human Lung Organoids

    Columbia University Medical Center – New York, New York, United States

    Research Group Leaders – Experimental Neurobiology and Brain Organoids

    Human Technopole Foundation – Milan, Italy

    Research Scientist – CRISPR Technology and Organoids

    Research Center for Molecular Medicine – Vienna, Austria

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