 | | Vol. 1.04 – 6 August, 2020 |
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| Intestinal exposure to inositol trisphosphate and phytate ingestion both promoted recovery following intestinal damage. Inositol trisphosphate also induced growth of patient-derived intestinal organoids, stimulated HDAC3-dependent proliferation, and countered butyrate inhibition of colonic growth.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers leveraged single-cell RNA sequencing in combination with in vivo lineage tracing and organoid models to finely map the trajectories of alveolar-lineage cells during injury repair and lung regeneration.
[Cell Stem Cell] |
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| Scientists propose a mechanistic theory of epithelial shells which resembled small-organoid morphologies. Using a 3D surface tension-based vertex model, they reproduced the characteristic shapes from branched and budded to invaginated structures.
[Nature Communications] |
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| Intestinal organoids were grown from rectal biopsies in a cohort of 97 subjects with cystic fibrosis. Residual CFTR function was measured by quantifying organoid swelling induced by forskolin and response to modulators by quantifying organoid swelling induced by CFTR correctors, potentiator and their combination. Organoid data were correlated with clinical data from literature.
[European Respiratory Journal] |
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| Genome and exome sequencing were performed for five unrelated cases of inherited retinal disease with no identified variant. In vitro assays were developed to validate the variants identified, including fibroblast assay, induced pluripotent stem cell derived retinal organoids, and a dynein motility assay.
[Genetics in Medicine] |
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| CRISPR-Cas9 technology deleted PKD1 in human induced pluripotent stem cells and the cells induced to differentiate along pathways leading to formation of either nephron progenitor or uteric bud organoids.
[Journal of the American Society of Nephrology] |
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| Researchers aimed to develop a novel kind of 3D organoids generated from urine-derived stem cells and to explore whether kidney-specific extracellular matrix could enable such organoids for renal function in vitro.
[Stem Cell Research & Therapy] |
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| Cell culture experiments were performed in human dermal microvascular endothelial cells and included mRNA and protein analysis, and cell migration and proliferation assays. Ex vivo skin organoid culture was used to evaluate the effect of OSM on perivascular fibrosis.
[Arthritis Research & Therapy] |
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| Investigators demonstrated that human midbrain organoids showed essential neuronal functional properties as spontaneous electrophysiological activity of different neuronal subtypes, including dopaminergic, GABAergic, glutamatergic and serotonergic neurons.
[Cell and Tissue Research] |
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| Organoids offer a new and exciting platform for studying cancer and directing personalized therapies. This review highlights how organoids are shaping the future of cancer research.
[British Journal of Cancer] |
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| Research advocates were eager to learn who Health and Human Services Secretary Alex Azar would appoint to the board and to see its ideological makeup. On July 31st they got their first look as it gathered online for a one-time meeting run by the National Institutes of Health.
[ScienceInsider] |
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| October 26 – October 28
Virtual |
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| | Icahn School of Medicine, Mount Sinai – New York City, New York, United States |
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| | Wayne State University – Detroit, Michigan, United States |
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| | Wellcome Sanger Institute – Cambridge, United Kingdom |
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| | University Medical Centre Groningen (UMCG) – Groningen, Netherlands |
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| | Institut Mondor de Recherche Biom̩dicale (IMRB) РCreteil, France |
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Cancer Stem Cell News
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