 | | Vol. 1.10 – 17 September, 2020 |
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| By using tissue engineering and the intrinsic self-organization properties of cells, researchers induced intestinal stem cells to form tube-shaped epithelia with an accessible lumen and a similar spatial arrangement of crypt- and villus-like domains to that in vivo.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The polygenic risk score predicted the susceptibility to drug-induced liver injury in patients treated with fasiglifam, amoxicillin–clavulanate or flucloxacillin and in primary hepatocytes and stem cell-derived organoids from multiple donors treated with over ten different drugs.
[Nature Medicine] |
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| Scientists provided an overview of the protocols used by different groups to establish organoids from various epithelial tissues and cancers, plus the different protocols subsequently used to test the in vitro therapy sensitivity of these patient-derived organoids.
[Nature Protocols] |
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| Investigators discovered that phospho-regulation of RNF43 was required for zebrafish development and growth of mouse intestinal organoids.
[Nature Communications] |
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| Researchers utilized a murine prostate organoid system to explore the effects of ERG on tumorigenesis and determined the mechanism underlying prostate cancer dependence on ERG.
[Cancer Research] |
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| Subcutaneously implanted kidney organoids in immunodeficient IL2Ry-/-RAG2-/- mice were successfully vascularized, maintained tubular and glomerular structures and retained capacity to produce renin two months after implantation.
[Kidney International] |
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| Scientists established murine and human 3D co-culture models of liver tumor organoids with cancer associated fibroblasts (CAFs). CAFs promoted tumor organoid growth in co-culture with direct cell-cell contact and in trans-well system via paracrine signaling.
[Cellular and Molecular Gastroenterology and Hepatology] |
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| Investigators report the roles of androgen in proliferation and differentiation of intestinal stem cells via targeting of the androgen receptor on intestinal stromal cells by negatively regulating bone morphogenetic proteins (BMP) signaling.
[Stem Cell Reports] |
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| Scientists analyzed whether bisphenol A or benzophenone-3 direct exposure affected the functional differentiation of the mammary gland using an in vitro model. Mammary organoids were obtained and isolated from eight week-old virgin female C57BL/6 mice.
[Environmental Research] |
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| Using a dextran sodium sulfate-induced colitis model, researchers explored the role of interferon regulatory factor-2 in maintaining colonic epithelial stem cells.
[Scientific Reports] |
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| The authors developed a three-dimensional hBORG model containing major cell types important for HIV-1 neuropathogenesis; neurons and astrocytes along with incorporation of HIV-infected microglia.
[Scientific Reports] |
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| The authors provide insights from developmental biology with a comprehensive resource of signaling pathways that in a coordinated manner form embryo-like structures and organoids. The advent of assembloids and multilineage organoids from PSCs opens a new dimension to study paracrine function and multi-tissue interactions in vitro.
[iScience] |
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| Curi Bio has announced the ComboMat™ platform, a proprietary human iPSC-derived cardiomyocyte maturation technology. Curi’s ComboMat platform leverages a combination of cues-including a proprietary microRNA cocktail-to drive the functional development and maturation of cardiomyocytes with applications in drug discovery, disease modeling, and safety and efficacy screening.
[Curi Bio] |
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| | Wayne State University – Detroit, Michigan, United States |
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| | Max-Planck Center for Tissue Stem Cell Research and Regenerative Medicine – Guangzhou, China or Maine, United States |
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| | Institut Mondor de Recherche Biomédicale (IMRB) – Creteil, France |
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| | Pennsylvania State University – Philadelphia, Pennsylvania, United States |
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| | Terasaki Research Institute – Los Angeles, California, United States |
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