Organoid News Volume 1.11 | Sep 24 2020

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    ON 1.11 | 24 Sep 2020


    Organoid News by STEMCELL Technologies
    Vol. 1.11 – 24 September, 2020
    TOP STORY

    Recapitulating Macro-Scale Tissue Self-Organization through Organoid Bioprinting

    Scientists introduced a three-dimensional bioprinting concept that used organoid-forming stem cells as building blocks that could be deposited directly into extracellular matrices conducive to spontaneous self-organization.
    [Nature Materials]

    Abstract

    Immunofluorescence image of adult stem cell-derived intestinal organoids.
    PUBLICATIONSRanked by the impact factor of the journal

    Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution

    The authors developed light-sensitive human retinal organoids with multiple nuclear and synaptic layers and functional synapses.
    [Cell]

    Full ArticleGraphical Abstract

    Human
    Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium

    Scientists investigated the susceptibility of human iPSC-derived monolayer brain cells and region-specific brain organoids to SARS-CoV-2 infection.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    Therapeutic Targeting of KSP in Preclinical Models of High-Risk Neuroblastoma

    The authors used human tumor organoids representing multiple MYCN-amplified high-risk neuroblastomas to perform a high-throughput drug screen with approved or emerging oncology drugs.
    [Science Translational Medicine]

    Abstract

    Enteroendocrine
    Cells Couple Nutrient Sensing to Nutrient Absorption by Regulating Ion Transport

    Researchers found that peptide YY was required in the small intestine to maintain normal electrophysiology in the presence of vasoactive intestinal polypeptide, a potent stimulator of ion secretion classically produced by enteric neurons.
    [Nature Communications]

    Full Article

    Multiplatform
    Genomic Profiling and Magnetic Resonance Imaging Identify Mechanisms Underlying Intratumor Heterogeneity in Meningioma

    Investigators developed a human cerebral organoid model of meningioma and validated the high ADC marker genes CDH2 and PTPRZ1 as potential targets for meningioma therapy.
    [Nature Communications]

    Full ArticlePress Release

    SARS-CoV-2 Targets Neurons of 3D Human Brain Organoids

    Scientists showed that a Düsseldorf isolate of SARS‐CoV‐2 entered 3D human brain organoids within two days of exposure. They identified that SARS‐CoV‐2 preferably targeted neurons of brain organoids.
    [EMBO Journal]

    Abstract

    Cholesterol
    25-Hydroxylase Inhibits SARS-CoV-2 and Coronaviruses by Depleting Membrane Cholesterol

    25‐hydrocholesterol inhibited USA‐WA1/2020 SARS‐CoV‐2 infection in lung epithelial cells and viral entry in human lung organoids.
    [EMBO Journal]

    Full Article

    Inhibition
    of Protein Tyrosine Phosphatase Receptor Type F Suppresses Wnt Signaling in Colorectal Cancer

    The rate of proliferation as well as colony formation ability were significantly decreased in tumor organoids grown in 3D, whereas the number of differentiated tumor organoids were markedly increased.
    [Oncogene]

    Abstract

    Human
    Induced Pluripotent Stem Cell-Derived Lung Organoids in an Ex Vivo Model of the Congenital Diaphragmatic Hernia Fetal Lung

    Researchers established a reproducible ex vivo model of lung development using transgene‐free human iPSCs generated from fetuses and infants with Bochdalek congenital diaphragmatic hernia, a polygenic disorder associated with fetal lung compression and pulmonary hypoplasia at birth.
    [Stem Cells Translational Medicine]

    Full Article

    Single-Cell
    RNA Sequencing Analysis of SARS-CoV-2 Entry Receptors in Human Organoids

    Scientists used single-cell RNA sequencing data of human organoids to analyze expressions of ACE2 and TMPRSS2, in addition to an array of RNA receptors to examine their role in SARS-CoV-2 pathogenesis.
    [Journal of Cellular Physiology]

    Full Article

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    REVIEWS

    Cell Fate Specification and Differentiation in the Adult Mammalian Intestine

    New approaches such as single-cell transcriptomics and the use of organoid models have led to the identification of the signals that guide fate specification of stem cell progeny into the six intestinal cell lineages. These cell types display context-dependent functionality and can adapt to different requirements over their lifetime, as dictated by their microenvironment.
    [Nature Reviews Molecular Cell Biology]

    Abstract

    Upgrading the Physiological Relevance of Human Brain Organoids

    The authors review recent advances in brain organoid generation and characterization with a focus on highlighting future directions utilizing interdisciplinary strategies that will be important for improving the physiological relevance of this model system.
    [Neuron]

    Abstract

    INDUSTRY AND POLICY NEWS

    Recce Pharmaceuticals Announces Positive & Concentration-dependent Efficacy of RECCE® Compounds against COVID-19 in International Study

    Recce Pharmaceuticals Ltd provided an update on their international SARS-CoV-2 in vitro (organoid) studies undertaken by Path BioAnalytics Inc. and The University of Tennessee Health Science Center.
    [Recce Pharmaceuticals Ltd (GlobeNewswire, Inc.)]

    Press Release

    FEATURED EVENT

    10
    Million Reasons to Defeat Cancer 2020 – Abbott World Summit

    October 13 – October 14
    Virtual


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    JOB OPPORTUNITIES

    Assistant/Associate
    Professor – Stem Cells and Organoid Models for Human Disease

    The University of Georgia – Athens, Georgia, United States

    Postdoctoral
    Scientist – Using Organoids in Autoimmunity and Cancer

    University Hospital of Muenster – Münster, Germany

    Research
    Positions – Organs on a Chip

    Terasaki Research Institute – Los Angeles, California, United States

    Postdoctoral Position – Lung Regeneration

    Institut Mondor de Recherche Biomédicale (IMRB) – Creteil, France


    Postdoctoral Scholar – Biomedical Engineering in Regenerative Medicine

    Pennsylvania State University – Philadelphia, Pennsylvania, United States

    > See All Jobs

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