 | | Vol. 1.13 – 8 October, 2020 |
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| By combining quantitative imaging with RNA sequencing, scientists showed the role of endogenous retinoic acid metabolism in initiating transcriptional programs that guide the cell-fate transitions of intestinal epithelium, and identified an inhibitor of the retinoid X receptor that improves intestinal regeneration in vivo.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists developed organoid systems from primary mouse and human induced pluripotent stem cell-derived lung epithelial cells to model early-stage lung adenocarcinoma.
[Cell Stem Cell] |
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| A microfluidic platform named IFlowPlate was engineered, which could be used to culture up to 128 independently perfused and vascularized colon organoids in vitro.
[Advanced Materials] |
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| Researchers established a human liver organoid (HLO) based screening model for analyzing DILI pathology at organoid resolution. HLO, generated from ten-different pluripotent stem cell lines, contained polarized immature hepatocytes with bile canaliculi-like architecture, establishing the unidirectional bile acid transport pathway.
[Gastroenterology] |
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| Investigators report the establishment a large cohort of unique organoids and patient-derived orthotopic xenografts (PDOX) of various glioma subtypes, including gliomas with mutations in IDH1, and paired longitudinal PDOX from primary and recurrent tumors of the same patient.
[Acta Neuropathologica] |
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| Researchers reprogrammed fibroblasts from affected individuals and controls into induced pluripotent stem cells and differentiated them into photoreceptor precursor cells or retinal organoids.
[American Journal of Human Genetics] |
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| Both TACSTD2high and TACSTD2low luminal cells transduced by constitutively activated AKT1, and c-Myc could form organoids containing versatile clinically relevant tumor cell lineages with regard to the expression of AR and the neuroendocrine cell markers Synaptophysin and Chromogranin A.
[Oncogene] |
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| Scientists describe a rat liver organoid culture system under in vivo-like steady-state flow conditions; this system was capable of controlling the expansion and differentiation of rat liver organoids over 10 to 15 days.
[Biofabrication] |
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| In small intestinal crypt organoids, overexpression of a C-terminal deletion mutant of LGR5 inhibited the growth and bud formation of organoids, whereas overexpression of the R-spondin-binding mutant of LGR5 that was defective for WNT signaling could still promote organoid growth.
[FASEB Journal] |
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| Scientists used three-dimensional co-culture methods to develop colonic organoids that contained enteric nerves and blood vessels. The development of enteric nerves and blood vessels was confirmed phenotypically and genetically by the use of immunofluorescent staining and Western blotting.
[Cells] |
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| The authors review organoids from primary tissues, cell lines, and stem cells, and introduce engineering studies when applicable. They discuss non‐invasive assessment of organoids, which can reveal the underlying biological mechanisms and enable improved assays for growth, metabolism, and function. Applications of organoids in cell therapy are also discussed.
[Biological Reviews] |
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| Researchers review mouse cellular systems genetics approaches for characterizing the influence of genetic variation on signaling networks and phenotypic diversity, and they discuss approaches for data integration and cross-species validation.
[Trends in Genetics] |
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| The authors discuss the most recent production methods, challenges currently faced in organoid and spheroid production, and microfabricated and microfluidic applications for improving spheroid and organoid generation.
[Microsystems & Nanoengineering] |
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| Allele Biotechnology and Pharmaceuticals, Inc. has been using mRNA as its core technology for creating cGMP-grade iPSC lines for regenerative medicine and oncology for over a decade. The have recently shown that mRNAs encoding the SARS-CoV-2 antigen proteins could be packaged in iPSCs and delivered in extracellular vesicles, potentially together with the viral proteins these mRNAs encode—a dual mRNA and protein vaccine, all naturally packaged in cells.
[Allele Biotechnology and Pharmaceuticals, Inc. (Businesswire, Inc.)] |
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| April 9 – April 14, 2021
Washington, DC, United States |
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| | The University of Georgia – Athens, Georgia, United States |
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| | University Hospital of Muenster – Münster, Germany |
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| | Terasaki Research Institute – Los Angeles, California, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Pennsylvania State University – Philadelphia, Pennsylvania, United States |
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| | Vitalant Research Institute – San Francisco, California, United States |
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