Organoid News Volume 1.14 | Oct 15 2020

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    ON 1.14 | Oct 15 2020


    Organoid News by STEMCELL Technologies
    Vol. 1.14 – 15 October, 2020
    TOP STORY

    Volumetric
    Compression Induces Intracellular Crowding to Control Intestinal Organoid Growth via Wnt/β-Catenin Signaling

    Investigators showed that volumetric compression regulated the growth of intestinal organoids by modifying intracellular crowding and elevating Wnt/β-catenin signaling.
    [Cell Stem Cell]

    AbstractPress Release
    Graphical Abstract

    Request your free copy of the 'Building Three-Dimensional Human Brain Organoids' Wallchart
    PUBLICATIONSRanked by the impact factor of the journal

    SARS-CoV-2
    Infects the Brain Choroid Plexus and Disrupts the Blood-CSF-Barrier in Human Brain Organoids

    Researchers used human pluripotent stem cell-derived brain organoids to examine SARS-CoV-2 neurotropism. They found expression of viral receptor ACE2 in mature choroid plexus cells expressing abundant lipoproteins, but not in neurons or other cell types.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    Targeting
    DNA Damage Response and Replication Stress in Pancreatic Cancer

    Scientists interrogated the transcriptome, genome, proteome and functional characteristics of 61 novel pancreatic cancer patient-derived cell lines to define novel therapeutic strategies targeting DNA damage response and replication stress. Validation was done in patient derived xenografts and human PC organoids.
    [Gastroenterology]

    Full ArticleGraphical Abstract

    Generation
    and Initial Characterization of Novel Tumor Organoid Models to Study Human Pancreatic Cancer-Induced Cachexia

    The authors established a pancreatic tumor organoid biobank from well‐phenotyped cachectic and non‐cachectic patients to enable identification of tumor‐derived factors driving cancer cachexia.
    [Journal of Cachexia Sarcopenia and Muscle]

    Full Article

    The
    ALPK1/TIFA/NF-κB Axis Links a Bacterial Carcinogen to R-Loop-Induced Replication Stress

    DNA damage depended on the bi-functional RfaE enzyme and the Cag pathogenicity island of H. pylori, was accompanied by replication fork stalling and could be observed also in primary cells derived from gastric organoids.
    [Nature Communications]

    Full Article

    Human
    Cerebral Organoids Establish Subcortical Projections in the Mouse Brain after Transplantation

    Researchers optimized a culturing protocol capable of efficiently generating small human cerebral organoids derived from hESCs and hiPSCs.
    [Molecular Psychiatry]

    Full Article

    Isolation
    and Culture of Human-Induced Pluripotent Stem Cell-Derived Cerebral Organoid Cells

    Scientists present a protocol to isolate and culture brain cells from two-month human iPSC-derived cerebral organoids. The dissociation and plating of cells from organoids takes three to four hours.
    [Methods in Molecular Biology]

    Abstract

    Cellular
    Senescence Contributes to Radiation-Induced Hyposalivation by Affecting the Stem/Progenitor Cell Niche

    Salivary gland-derived organoids showed increased expression of senescence markers and pro-inflammatory senescence-associated secretory phenotype factors after radiation exposure.
    [Cell Death & Disease]

    Full Article

    Glucosylceramide
    Production Maintains Colon Integrity in Response to Bacteroides Fragilis Toxin-Induced Colon Epithelial Cell Signaling

    Scientists showed that Bacteroides fragilis toxin increased levels of glucosylceramide, a vital intestinal sphingolipid, both in mice and in colon organoids generated from the distal colons of mice.
    [FASEB Journal]

    Full Article

    Organoids
    to Study Intestinal Nutrient Transport, Drug Uptake and Metabolism – Update to the Human Model and Expansion of Applications

    The authors verified the applicability of 3D organoids for in vitro investigation of intestinal biochemical processes related to transport and metabolism of nutrients and drugs.
    [Frontiers in Bioengineering and Biotechnology]

    Full ArticlePress Release

    Modeling
    Alcohol-Induced Neurotoxicity Using Human Induced Pluripotent Stem Cell-Derived Three-Dimensional Cerebral Organoids

    Modeling binge drinking using iPSC-derived human cerebral organoids, scientists sought to quantify the downstream toxic effects of alcohol (ethanol) on neural pathology phenotypes and signaling pathways within the organoids.
    [Translational Psychiatry]

    Full Article

    Establishing
    a Living Biobank of Patient-Derived Organoids of Intraductal Papillary Mucinous Neoplasms of the Pancreas

    Organoids are an ideal preclinical platform to study intraductal papillary mucinous neoplasms (IPMNs), and the objective of the current investigation was to establish a living biobank of patient-derived organoids from IPMNs.
    [Laboratory Investigation]

    Abstract

    Grow Functional Airway Organoids with PneumaCult™
    REVIEWS

    A Materials-Science Perspective on Tackling COVID-19

    The authors investigate future possibilities of materials science in antiviral research and treatment development, examining the role of materials in antiviral-drug design, including the importance of synthetic material platforms for organoids and organs-on-a-chip, in drug delivery and vaccination, and for the production of medical equipment.
    [Nature Reviews Materials]

    Full Article

    INDUSTRY AND POLICY NEWS

    Axol Biosciences Offers New Screening Assay for hiPSC-Derived Cells

    Axol Biosciences has added multi-electrode array (MEA) screening services for human-iPSC-derived cells to its service offering for preclinical drug discovery. The company said that its new MEA screening services optimize hiPSC-derived cell culture, while also providing electrophysiology acquisition and analysis from physiologically relevant human cell models.
    [The Science Advisory Board]

    Press Release

    FEATURED EVENT

    Cell Symposia: 20 Years of the Human Genome: From Sequence to Substance

    April 11 – April 13 2021
    San Diego, California, United States


    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Neuroscience and Stem Cell Biology

    The University of British Columbia – Vancouver, British Columbia, Canada

    Research
    Positions – Organs on a Chip

    Terasaki Research Institute – Los Angeles, California, United States


    Faculty Position – Stem Cells and Regenerative Medicine

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellow – Stem Cells and Organoid Biology

    Max-Planck Center for Tissue Stem Cell Research and Regenerative Medicine – Guangzhou, China or Maine, United States

    Assistant/Associate
    Professor – Stem Cells and Organoid Models for Human Disease

    The University of Georgia – Athens, Georgia, United States

    > See All Jobs

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