| Vol. 1.14 – 15 October, 2020 |
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| Investigators showed that volumetric compression regulated the growth of intestinal organoids by modifying intracellular crowding and elevating Wnt/β-catenin signaling. [Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers used human pluripotent stem cell-derived brain organoids to examine SARS-CoV-2 neurotropism. They found expression of viral receptor ACE2 in mature choroid plexus cells expressing abundant lipoproteins, but not in neurons or other cell types. [Cell Stem Cell] |
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| Scientists interrogated the transcriptome, genome, proteome and functional characteristics of 61 novel pancreatic cancer patient-derived cell lines to define novel therapeutic strategies targeting DNA damage response and replication stress. Validation was done in patient derived xenografts and human PC organoids. [Gastroenterology] |
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| The authors established a pancreatic tumor organoid biobank from well‐phenotyped cachectic and non‐cachectic patients to enable identification of tumor‐derived factors driving cancer cachexia. [Journal of Cachexia Sarcopenia and Muscle] |
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| DNA damage depended on the bi-functional RfaE enzyme and the Cag pathogenicity island of H. pylori, was accompanied by replication fork stalling and could be observed also in primary cells derived from gastric organoids. [Nature Communications] |
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| Researchers optimized a culturing protocol capable of efficiently generating small human cerebral organoids derived from hESCs and hiPSCs. [Molecular Psychiatry] |
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| Scientists present a protocol to isolate and culture brain cells from two-month human iPSC-derived cerebral organoids. The dissociation and plating of cells from organoids takes three to four hours. [Methods in Molecular Biology] |
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| Salivary gland-derived organoids showed increased expression of senescence markers and pro-inflammatory senescence-associated secretory phenotype factors after radiation exposure. [Cell Death & Disease] |
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| Scientists showed that Bacteroides fragilis toxin increased levels of glucosylceramide, a vital intestinal sphingolipid, both in mice and in colon organoids generated from the distal colons of mice. [FASEB Journal] |
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| The authors verified the applicability of 3D organoids for in vitro investigation of intestinal biochemical processes related to transport and metabolism of nutrients and drugs. [Frontiers in Bioengineering and Biotechnology] |
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| Modeling binge drinking using iPSC-derived human cerebral organoids, scientists sought to quantify the downstream toxic effects of alcohol (ethanol) on neural pathology phenotypes and signaling pathways within the organoids. [Translational Psychiatry] |
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| Organoids are an ideal preclinical platform to study intraductal papillary mucinous neoplasms (IPMNs), and the objective of the current investigation was to establish a living biobank of patient-derived organoids from IPMNs. [Laboratory Investigation] |
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| The authors investigate future possibilities of materials science in antiviral research and treatment development, examining the role of materials in antiviral-drug design, including the importance of synthetic material platforms for organoids and organs-on-a-chip, in drug delivery and vaccination, and for the production of medical equipment. [Nature Reviews Materials] |
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| Axol Biosciences has added multi-electrode array (MEA) screening services for human-iPSC-derived cells to its service offering for preclinical drug discovery. The company said that its new MEA screening services optimize hiPSC-derived cell culture, while also providing electrophysiology acquisition and analysis from physiologically relevant human cell models. [The Science Advisory Board] |
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| April 11 – April 13 2021 San Diego, California, United States |
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| The University of British Columbia – Vancouver, British Columbia, Canada |
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| Terasaki Research Institute – Los Angeles, California, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| Max-Planck Center for Tissue Stem Cell Research and Regenerative Medicine – Guangzhou, China or Maine, United States |
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| The University of Georgia – Athens, Georgia, United States |
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