Organoid News Volume 1.17 | Nov 5 2020

May 12, 2022

ON 1.17 | Nov 5 2020

Vol. 1.17 – 5 November, 2020

TOP STORY

Inhibition of LTβR Signaling Activates WNT-Induced Regeneration in Lung

Scientists demonstrated increased expression of lymphotoxin β-receptor (LTβR) ligands in adaptive and innate immune cells, enhanced non-canonical NF-κB signaling, and enriched LTβR target gene expression in lung epithelial cells from patients with smoking-associated chronic obstructive pulmonary disease.
[Nature]

Full Article

Virtual Poster Presentation: CRISPR-Cas9 Gene Editing of Cerebral Organoids to Model Microcephaly

PUBLICATIONSRanked by the impact factor of the journal

A
Human Tissue Screen Identifies a Regulator of ER Secretion as a Brain Size Determinant

Investigators present CRISPR-LIneage tracing at cellular resolution in Heterogenous Tissue, enabling parallel loss-of-function studies in human cerebral organoid tissue.
[Science]

Abstract

Defining
the Teratoma as a Model for Multi-Lineage Human Development

Researchers showed that inter-teratoma cell type heterogeneity was comparable with organoid systems, and teratoma gut and brain cell types corresponded well to similar fetal cell types.
[Cell]

Abstract Graphical Abstract

Role
of Specialized Composition of SWI/SNF Complexes in Prostate Cancer Lineage Plasticity

The authors investigated the role of the mammalian SWI/SNF (mSWI/SNF) chromatin remodeling complex in neuroendocrine prostate cancer (NEPC). Using patient-derived organoids and cancer cell lines, they identified mSWI/SNF subunits deregulated in NEPC and demonstrated that SMARCA4 overexpression was associated with aggressive disease.
[Nature Communications]

Full Article

APOE4
Exacerbates Synapse Loss and Neurodegeneration in Alzheimer’s Disease Patient iPSC-Derived Cerebral Organoids

Researchers developed cerebral organoid models using induced pluripotent stem cells with APOE ε3/ε3 or ε4/ε4 genotype from individuals with either normal cognition or Alzheimer’s disease dementia.
[Nature Communications]

Full Article

Liver-Expressed
Cd302 and Cr1l Limit Hepatitis C Virus Cross-Species Transmission to Mice

Murine hepatocyte expression of both factors was constitutive and not interferon inducible, while differences in liver expression and the ability to restrict hepatitis C virus were observed between the murine orthologs and their human counterparts.
[Science Advances]

Full Article

Improvement
of Islet Transplantation by the Fusion of Islet Cells with Functional Blood Vessels

Scientists introduce a novel strategy for the generation of prevascularized islet organoids by the fusion of pancreatic islet cells with functional native microvessels.
[EMBO Molecular Medicine]

Full Article

Intestinal miRNAs Regulated in Response to Dietary Lipids

Classic and recent intestinal in vitro models (i.e. differentiated Caco-2 cells and murine organoids) partially mirrored miRNA modulation in response to lipid challenges in vivo.
[Scientific Reports]

Full Article

Expression of a Novel Brain Specific Isoform of C3G Is Regulated during Development

Researchers identified brain specific expression of a novel C3G isoform in mice and humans. This isoform has an insert in the Crk-binding region, generating a polypeptide of 175 kDa, unlike the previously known 140 kDa form expressed in all other tissues.
[Scientific Reports]

Full Article

Enhanced
Collagen Deposition in the Duodenum of Patients with Hyaline Fibromatosis Syndrome and Protein Losing Enteropathy

Intestinal organoids were generated from one of the patients, along with CRISPR-Cas9 ANTXR2 knockout, and compared with organoids from two healthy controls.
[International Journal of Molecular Sciences]

Full Article

Grow Functional Airway Organoids with PneumaCult™

REVIEWS

CRISPR-Cas
Tools and Their Application in Genetic Engineering of Human Stem Cells and Organoids

The authors review CRISPR-Cas systems and their latest developments with an emphasis on application to human cells. They also discuss how different CRISPR-based strategies can be used to accomplish a particular genome engineering goal.
[Cell Stem Cell]

Abstract

Brain Organoids for the Study of Human Neurobiology at the Interface of In
Vitro and In Vivo

Investigators describe the efforts to recapitulate brain development in neural organoids and focus on their applicability for disease modeling, evolutionary studies and neural network research.
[Nature Neuroscience]

Abstract

Modeling
Brain Development and Diseases with Human Cerebral Organoids

The authors summarize the recent advances in the development of brain organoid technology and discussed the limitations, applications and future prospects of this promising field.
[Current Opinion in Neurobiology]

Full Article

INDUSTRY AND POLICY NEWS

IMAC Holdings, Inc. Announces Opening Enrollment in Its Phase I Clinical Study of Umbilical Cord-Derived Mesenchymal Stem Cells for the Treatment of Bradykinesia Due to Parkinson’s Disease

IMAC Holdings, Inc. announces it is opening enrollment in its Phase I clinical trial for its investigational compound utilizing umbilical cord-derived allogenic mesenchymal stem cells for the treatment of bradykinesia, or the gradual slowing and loss of spontaneous body movement, due to Parkinson’s disease.
IMAC Holdings, Inc. [Globe Newswire, Inc.]

FEATURED EVENT

Inhibition of LTβR Signaling Activates WNT-Induced Regeneration in Lung

A
Human Tissue Screen Identifies a Regulator of ER Secretion as a Brain Size Determinant

Defining
the Teratoma as a Model for Multi-Lineage Human Development

Role
of Specialized Composition of SWI/SNF Complexes in Prostate Cancer Lineage Plasticity

APOE4
Exacerbates Synapse Loss and Neurodegeneration in Alzheimer’s Disease Patient iPSC-Derived Cerebral Organoids

Liver-Expressed
Cd302 and Cr1l Limit Hepatitis C Virus Cross-Species Transmission to Mice

Improvement
of Islet Transplantation by the Fusion of Islet Cells with Functional Blood Vessels

Intestinal miRNAs Regulated in Response to Dietary Lipids

Expression of a Novel Brain Specific Isoform of C3G Is Regulated during Development

Enhanced
Collagen Deposition in the Duodenum of Patients with Hyaline Fibromatosis Syndrome and Protein Losing Enteropathy

CRISPR-Cas
Tools and Their Application in Genetic Engineering of Human Stem Cells and Organoids

Brain Organoids for the Study of Human Neurobiology at the Interface of In
Vitro and In Vivo

Modeling
Brain Development and Diseases with Human Cerebral Organoids

IMAC Holdings, Inc. Announces Opening Enrollment in Its Phase I Clinical Study of Umbilical Cord-Derived Mesenchymal Stem Cells for the Treatment of Bradykinesia Due to Parkinson’s Disease

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