 | | Vol. 1.18 – 12 November, 2020 |
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| Scientists established 25 lines of neuroendocrine carcinoma (NEN) organoids and performed their comprehensive molecular characterization. Gastroenteropancreatic-NEN organoids recapitulated pathohistological and functional phenotypes of the original tumors.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| By engineering mouse fallopian tube epithelial organoids using lentiviral gene transduction and/or CRISPR/Cas9 mutagenesis, researchers generated multiple high grade serous tubo-ovarian carcinoma (HGSC) models exhibiting mutational combinations seen in HGSC patients.
[Cancer Discovery] |
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| The authors showed that mouse embryonic stem cells could be coaxed to robustly undergo fundamental steps of early heart organogenesis with an in vivo-like spatiotemporal fidelity.
[Cell Stem Cell] |
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| Scientists describe detailed procedures for generating glioblastoma organoids from surgically resected patient tumor tissue using a chemically defined medium without cell dissociation.
[Nature Protocols] |
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| Investigators profiled a lymphangioleiomyomatosis (LAM) lung compared to an age- and sex-matched healthy control lung as a hypothesis-generating approach to identify cell subtypes that are specific to LAM.
[Nature Communications] |
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| The authors clarified the mechanisms by which epithelial MyD88 contributed to intestinal tumor formation and to address whether MyD88 could be a therapeutic target of colorectal cancer.
[Oncogene] |
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| Researchers employed human intestinal organoids derived from PSCs to dissect SARS-CoV-2 pathogenesis and its inhibition by remdesivir, one of the leading drugs investigated for treatment of COVID-19.
[Cellular and Molecular Gastroenterology and Hepatology] |
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| Scientists investigated the role of endocannabinoid signaling in mouse pluripotent embryonic stem cell-derived neuronal differentiation. Incubation with CB1 receptor agonists during human iPSC-derived cerebral organoid formation promoted the expansion of BCL11B+ neurons.
[Development] |
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| Investigators evaluated the ex vivo response of patient tumor-derived organoids (or mammospheres) to chemotherapy alone or in combination with P2Et. A xenotransplant model engrafted with MDA-MB-468 was used to evaluate the in vivo activity of P2Et.
[Scientific Reports] |
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| Researchers define intestinal epithelial barrier function in human intestinal organoid-derived tissue-engineered small intestine.
[Journal of Surgical Research] |
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| Scientists provide an update of the main signal pathways involved in vascular cell differentiation from human PSCs and an extensive overview of PSC-derived tissue organoids, highlighting the most recent discoveries in the field of blood vessel organoids as well as vascularization of other complex tissue organoids.
[Cardiovascular Research] |
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| As the mechanical properties of a complex tissue environment are challenging to replicate in vitro, emphasis has been placed on studies conducted in vivo or using organoid models.
[Seminars in Cell & Developmental Biology] |
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| Proteintech and HebeCell announced their collaborative partnership to develop proprietary nanobody based chimeric antigen receptor technology for the development and commercialization of iPSC-derived natural killer cells, a promising cellular immunotherapy treatment for cancer and other diseases.
[Proteintech Group, Inc.] |
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| May 18 – May 21, 2021
Hannover, Germany |
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| | New York Blood Center – New York, New York, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | Terasaki Research Institute – Los Angeles, California, United States |
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