 | | Vol. 1.19 – 19 November, 2020 |
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| Researchers found that shape change was regulated by a β-catenin-mediated decrease in RhoA activity and subsequent decrease in the plasma membrane tension. Preventing a decrease in membrane tension resulted in early differentiation defects in ESCs and gastruloids.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors established a screening strategy to identify drugs that reduce angiotensin converting enzyme 2 levels in human ESC-derived cardiac cells and lung organoids.
[Cell Stem Cell] |
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| Researchers demonstrated that ACE2‐Fc could specifically abrogate virus replication by blocking the entry of SARS‐CoV‐2 spike‐expressing pseudotyped virus into both ACE2‐expressing lung cells and lung organoids.
[EMBO Molecular Medicine] |
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| Scientists investigated the additive effect of combination therapy using remdesivir with recombinant soluble ACE2 on Vero E6 and kidney organoids, targeting two different modalities of SARS‐CoV‐2 life cycle: cell entry via its receptor ACE2 and intracellular viral RNA replication.
[EMBO Molecular Medicine] |
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| Investigators showed that the upregulation of SOX2 was central to cancer-associated fibroblasts (CAFs) promoting tumor malignancy, which was repressed by protein kinase Cζ (PKCζ). PKCζ deficiency activated the reprogramming of colonic fibroblasts to generate a predominant SOX2-dependent CAF population expressing the WNT regulator Sfrp2 as its top biomarker.
[Developmental Cell] |
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| Scientists revealed reduced reactivity of the astrocytic glial fibrillary acidic protein in the degenerated substantia nigra of PRKN-mutated patients, as well as in midbrain organoids generated from iPSCs reprogramed from PRKN-mutated patient fibroblasts.
[npj Parkinson’s Disease] |
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| Researchers describe a fully defined feeder-free protocol to generate early testis-like cells with the ability to be cultured as an organoid, from human induced pluripotent stem cells.
[Stem Cell Reports] |
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| Organoid-derived CD44(−) cancer cells were capable of organoid re-formation and could be re-programed as CD44-expressing cancer-initiating cells in the organoid culture system.
[Cancer Letters] |
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| An Hsp90 inhibitor, 17-AAG, significantly suppressed MERS-CoV propagation in cell lines and physiological-relevant human intestinal organoids.
[Emerging Microbes & Infections] |
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| Researchers generated an isogenic mutant in the general stress response sigma factor RpoS and employed this mutant to compare challenges faced by a bacterium during colonization of the human intestinal organoids lumen relative to the germ-free mouse intestine.
[mSphere] |
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| To create a model system of these cartilage-bone interactions, researchers developed an osteochondral organoid from murine induced pluripotent stem cells. They grew organoids from a single cell type through time-dependent sequential exposure of growth factors to mirror bone development through endochondral ossification.
[Tissue Engineering] |
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| The authors underline the need for providing engineering solutions to gain control of self-organization and functionality of human PSC-derived organoids.
[Nature Materials] |
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| Novel bioengineered models, organoid systems, and microfabrication technologies, such as 3D bioprinting, have delivered key innovations towards more advanced platforms for tumor modeling in vitro.
[Trends in Cancer] |
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| Scientists review the recent portfolios of primary tissue-derived and PSC-derived organoids in the digestive systems. They also discuss the promise and challenges in disease modeling and drug development applications for digestive disorders.
[Cell Death & Differentiation] |
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| Proteintech and HebeCell announced their collaborative partnership to develop proprietary nanobody based chimeric antigen receptor technology for the development and commercialization of iPSC-derived natural killer cells, a promising cellular immunotherapy treatment for cancer and other diseases.
[Proteintech] |
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| March 17 – March 19, 2021
Virtual |
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| | Ncardia – Share Gosselies, Belgium |
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| | New York Blood Center – New York, New York, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
