 | | Vol. 1.22 – 10 December, 2020 |
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| Collagen scaffolding assembly methods are provided, along with the microfabrication and soft lithography protocols necessary to shape the hydrogels to match the dimensions and density of in vivo crypts.
[Nature Protocols] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors demonstrated that tumor-derived UBR5, an E3 ligase overexpressed in human ovarian cancer (OC) associated with poor prognosis, was essential for OC progression principally by promoting tumor-associated macrophage recruitment and activation via key chemokines and cytokines.
[Nature Communications] |
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| In this model, alveolar cells, but also basal cells and rare neuroendocrine cells, were grown from 3D self‐renewing fetal lung bud tip organoids.
[EMBO Journal] |
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| Using a strategic series of increasingly complex human stem cell‐derived technologies, including human neurons, MECP2‐mosaic neurospheres to model Rett syndrome female brain mosaicism, and cortical organoids, researchers identified synaptic dysregulation downstream from knockout (KO) of MECP2.
[EMBO Molecular Medicine] |
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| Investigators drew parallels between the transcriptomes of ex vivo tissues and in vitro fetal organoids, revealing the maturation of organoid cultures in a dish.
[Developmental Cell] |
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| Scientists demonstrated that integrated analysis and engineering of gene regulatory networks in PSC-derived multilineage human liver organoids directed maturation and vascular morphogenesis in vitro.
[Cell Systems] |
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| Afatinib alone or in combination with gemcitabine decreased stemness and tumorspheres by reducing phosphorylation of EGFR family proteins, ERK, FAK, and cancer stem cell (CSC) markers. Mechanistically, afatinib treatment decreased CSC markers by downregulating SOX9 via FOXA2.
[Oncogene] |
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| Brain organoids grown from human pluripotent stem cells self-organize into cytoarchitectures resembling the developing human brain. Investigators present the SCOUT pipeline for automated multiscale comparative analysis of intact cerebral organoids.
[Scientific Reports] |
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| The authors created the first 3D adipose tissue organoid model which could contain and maintain resident immune cell populations of the stromal vascular fraction and proved to be effective in studying adipose tissue biology in a convenient manner.
[Scientific Reports] |
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| Scientists describe how the contribution of stem-cell-derived culture systems have helped our understanding of SARS-CoV-2 pathogenesis.
[Cell Stem Cell] |
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| Cytovia Therapeutics announced that it plans to file with the FDA in 2021 an Investigational New Drug application and initiate clinical trials in hematological and solid tumors with its Universal iPSC NK cell therapy.
[Cytovia Therapeutics (GlobeNewswire, Inc.)] |
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| February 22 – 23, 2021
Virtual |
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| | Genentech, Inc. – South San Francisco, California, United States |
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| | Ncardia – Share Gosselies, Belgium |
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| | New York Blood Center – New York, New York, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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