 | | Vol. 1.23 – 17 December, 2020 |
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| Scientists created multilayer bladder ‘assembloids’ by reconstituting tissue stem cells with stromal components to represent an organized architecture with an epithelium surrounding stroma and an outer muscle layer.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators derived organoids resembling the cerebral cortex or the hindbrain/spinal cord and assemble them with human skeletal muscle spheroids to generate 3D cortico-motor assembloids.
[Cell] |
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| Researchers describe a modified protocol that could be used to reliably generate cerebral organoids of a telencephalic identity and maintain long-term viability for later stages of neural development, including axon outgrowth and neuronal maturation.
[Nature Protocols] |
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| Scientists provide details on the analysis of colorectal tumor growth and metastasis. Intestinal epithelial organoids are required if co-culture experiments with cancer-associated fibroblasts are to be undertaken.
[Nature Protocols] |
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| Investigators developed an ex vivo experimental system, based on the intraluminal microinjection of Listeria in untreated, pharmacologically treated, and genetically modified intestinal organoids
[Current Biology] |
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| By independently generating two kidney progenitor cell populations, metanephric mesenchyme and ureteric bud-like cells, researchers generated kidney organoids with a collecting system.
[Cell Reports] |
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| The authors reported a real-time integrated system by generating 3D ex vivo cerebral organoids.
[Cancer Letters] |
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| Using a serial organoid formation assay, scientists tested the potential of G9a inhibition to affect the tumor-initiating capacity of primary colorectal cancer stem cells.
[Oncogene] |
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| Researchers present a new gut on chip model that allows the co-culture of primary epithelial and stromal cells. Mouse organoids, when deposited into crypts, opened up and epithelialized the scaffold, generating a polarized epithelial monolayer.
[Lab on a Chip] |
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| Due to the inaccessibility of brain tissues from human Niemann-Pick disease, type C (NPC) patients, investigators developed NPC brain organoids with induced neural stem cells from NPC patient-derived fibroblasts.
[Cell Death & Disease] |
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| Characterization showed both organoid types were highly similar, though some differences in size and gene expression were observed. Both extrahepatic cholangiocyte organoids and intrahepatic cholangiocyte organoids have cholangiocyte fate differentiation capacity.
[Scientific Reports] |
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| Using single-cell RNA sequencing analysis, scintists found that Olfactomedin 4 (OLFM4) was expressed in multiple stem/progenitor-like cell populations in both the normal prostate epithelium and RWPE1 cells and was frequently co-expressed with KRT13 and LY6D in RWPE1 cells.
[Scientific Reports] |
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| The authors highlight the most significant developments that have led to microphysiological human mini-brain models.
[Nature Biomedical Engineering] |
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| Investigators wanted to study how the near-weightless, microgravitational environment of the International Space Station affects building-block cells in the hope of understanding some of the secrets of how they grow, divide and form into tissues.
[The Washington Post] |
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| January 7 – 8, 2021
Virtual |
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| | Lieber Institute for Brain Development – Baltimore, Maryland, United States |
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| | Genentech, Inc. – South San Francisco, California, United States |
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| | Ncardia – Share Gosselies, Belgium |
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| | New York Blood Center – New York, New York, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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