 | | Vol. 2.00 – 7 January, 2021 |
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| Scientists discovered non-canonical Wnt/planar cell polarity (PCP)-activated intestinal stem cells that are primed towards the enteroendocrine or Paneth cell lineage.
[Nature Cell Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers sought to delineate tissue-specific contributions of Selenoprotein P (SELENOP) to intestinal inflammatory carcinogenesis and define clinical context. SELENOP loss was assessed in human ulcerative colitis organoids, and expression was queried in human and adult UC samples.
[Gastroenterology] |
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| Structured illumination microscopy imaging of pluripotent stem cell-derived organoids with NapBu-BPEA demonstrated the potential of super-resolution morphology-correlated organelle identification to track biospecies and events in specific organelles within organoids.
[Nature Communications] |
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| Transcriptional profiling of Apc deficient intestinal tissue identified Vav3 and Tiam1 as key targets.
[Nature Communications] |
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| In 3D organoid models, genetic knockdown of Rab Coupling Protein (Rab11‐FIP1) resulted in increased organoid size. Loss of Rab11‐FIP1 increased tumor cell invasion in part through mutant p53 but also in an independent manner.
[EMBO Reports] |
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| Investigators report the development of in vitro models consisting of colorectal cancer patient-derived organoid encapsulated within a well-defined three-dimensional hyaluronan-gelatin hydrogel and co-cultured with patient-derived cancer-associated fibroblasts.
[Acta Biomaterialia] |
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| Researchers report that the SARS-CoV-2 spike multibasic cleavage site increased infectivity on human airway organoids (hAOs). Compared with SARS-CoV, SARS-CoV-2 entered faster into Calu-3 cells, and more frequently formed syncytia in hAOs.
[Elife] |
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| The authors found that 5-HT6R was highly expressed in human neural stem cells (NSCs) and activation of the receptor promoted self-renewal of human NSCs, and thus induced the expansion and folding of human cerebral organoids; dysfunction of receptor or inhibition of its constitutive activity resulted in the premature differentiation of NSCs.
[Stem Cell Reports] |
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| In order to quantify the influence of cell proliferation on the observed cell lineage type clustering, scientists developed an agent-based model accounting for mechanical cell-cell interaction.
[Scientific Reports] |
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| Matched human enteroid and colonoid lines, generated from ileal and colon biopsies from two donors, were cultured in extracellular matrix for three days, followed by a single 48h treatment with rifampin, omeprazole, CITCO and phenytoin at concentrations that induce target genes in hepatocytes.
[Drug Metabolism and Disposition] |
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| The authors introduce the application of microfluidic chips in developing cancer preclinical models, detecting cancer biomarkers, screening anti-cancer drugs, exploring tumor heterogeneity and producing nano-drugs. They highlight the functions and recent development of microfluidic chip to provide references for advancing cancer diagnosis and treatment.
[Nanotheranostics] |
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Spinogenix, Inc. announced that it will be collaborating with Dr. Rita Sattler at the Barrow Neurological Institute and Dr. Justin Ichida at the USC Keck School of Medicine on a grant awarded from the US Department of Defense’s (DOD) Congressionally Directed Medical Research Programs to evaluate its lead development candidate in ALS. The DOD grant will be used to study the effects of Spinogenix’s lead compound in human iPSCs from patients with ALS and from healthy volunteers.
[Spinogenix, Inc. (GlobeNewswire, Inc.)] |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of Luxembourg – Belval, Luxembourg |
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| | Lieber Institute for Brain Development – Baltimore, Maryland, United States |
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| | Genentech, Inc. – South San Francisco, California, United States |
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| | National Institute of Arthritis and Musculoskeletal and Skin Diseases – Washington, DC, United States |
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