| Vol. 2.04 – 4 February, 2021 |
| |
|
|
| Researchers showed that the combination of Kras mutation and tissue damage promoted a unique chromatin state in the pancreatic epithelium that distinguished neoplastic transformation from normal regeneration and was selected for throughout malignant evolution. [Nature] |
|
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists bioprinted iPSC-derived cardiac microtissue models with spatially controlled cardiomyocyte and fibroblast cell ratios to replicate the structural and functional features of scarred cardiac tissue that arise following myocardial infarction, including reduced contractility and irregular electrical activity. [Nature Communications] |
|
|
|
| The authors showed that mutually exclusive prostate cancer driver alterations involving the ERG transcription factor and the ubiquitin ligase adaptor SPOP were synthetic sick. [Nature Communications] |
|
|
|
| Investigators proposed RAD50-interacting protein 1 (RINT1) as an essential mediator of cellular homeostasis in pancreatic ductal adenocarcinoma. RINT1 depletion caused severe growth defects in vitro associated with accumulation of DNA double-strand breaks, G2 cell cycle arrest, disruption of Golgi-ER homeostasis, and cell death. [Cancer Research] |
|
|
|
| Human kidney organoids were used for infectivity studies of SARS-CoV-2 in a BSL-3 facility to examine the neutralizing effect of novel ACE2 variants. [Journal of the American Society of Nephrology] |
|
|
|
| The authors compared transcriptome and cellular phenotypes between telencephalic organoids and monolayers generated in parallel from three biologically distinct iPSCs. [Stem Cell Reports] |
|
|
|
| Researchers established an in vitro model of CRX-Leber congenital amaurosis in retinal organoids that showed defective photoreceptor maturation by histology and gene profiling, with diminished expression of visual opsins. [Stem Cell Reports] |
|
|
|
| Paneth cell-specific knockout of Cdk5rap3 caused partial loss of Paneth cells, while inducible acute deletion of Cdk5rap3 resulted in disassembly of the rough endoplasmic reticulum and abnormal zymogen granules in the mature Paneth cells, as well as loss of Paneth cells. [Cell Death & Disease] |
|
|
|
| Scientists demonstrated the generation of enterocyte-like cells by culturing human iPSC-derived intestinal progenitor cells on a collagen vitrigel membrane. [Stem Cell Reports] |
|
|
|
| Investigators describe a three-dimensional culture system for the long-term expansion of patient-derived oapillary thyroid cancer organoid lines. [Journal of Clinical Endocrinology & Metabolism] |
|
|
|
| The authors showed that the ciMIC cells maintained long-term proliferative activity under two-dimensional niche factor-containing culture condition, retained the biological characteristics of intestinal epithelial stem cells, and could form intestinal organoids in three-dimensional culture. [Genes & Diseases] |
|
|
|
| Researchers demonstrated a practical, and widely applicable approach that included the successful reprogramming of somatic cells from a patient with a urea cycle defect, their genetic correction and differentiation into hepatic organoids. [International Journal of Molecular Sciences] |
|
|
|
| Investigators used intestinal organoids to explore the effects of metformin on intestinal cell physiology. [Scientific Reports] |
|
|
|
|
| Scientists provide an overview of how recent developments in the adult stem cell research field are changing our thinking of the definition of salivary gland stem cells and their potential plasticity upon damage. [npj Regenerative Medicine] |
|
|
|
| The authors review the recent methods of cultivating lung organoids, applications of lung organoids in epithelial repair after injury, and understanding the mechanisms of epithelial repair investigated using lung organoids. [Stem Cell Research & Therapy] |
|
|
|
|
| The National Eye Institute has awarded a team led by Dr. Maria Natalia Vergara at the Sue Anschutz-Rodgers Eye Center, University of Colorado $60,000 for developing an organoid derived from stem cells engineered to fluoresce. This method allows the organoid to demonstrate the cellular composition more clearly and efficiently. [National Eye Institute] |
|
|
|
|
| February 18, 2021 Virtual |
|
|
|
|
|
| St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
|
|
|
| Queen Mary University of London – London, England, United Kingdom |
|
|
|
| University of Luxembourg – Luxembourg City, Luxembourg |
|
|
|
| The University of British Columbia – Vancouver, British Columbia, Canada |
|
|
|
| University of Luxembourg – Belval, Luxembourg |
|
|
|
|