 | | Vol. 2.09 – 11 March, 2021 |
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| Functional validation studies of sex steroids implicated in cardiac maturation were performed in human pluripotent stem cell-derived cardiac organoids and mice.
[Circulation] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| By performing genome-wide ChIP-seq profiling in enzalutamide -resistant castration-resistant prostate cancer cells, scientists identified a set of androgen receptor (AR) binding sites with increased AR binding intensity.
[Nature Communications] |
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| Investigators report that carcinoma-associated fibroblasts induced β5 integrin expression in tumor cells in a TGF-β dependent manner, making them an efficient drug delivery target for the tumor-penetrating peptide iRGD.
[Nature Communications] |
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| Scientists describe a detailed protocol for establishing tubuloid cultures from tissue and urine, as well as for generating and characterizing tubuloid cell–derived 3D tubular structures in a perfused microfluidic multi-chip platform.
[Nature Protocols] |
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| The authors introduced an optimized method for orthotopic organoid transplantation in mice, which included injection of organoids and estrogen pellets without the need for surgery.
[Nature Protocols] |
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| Investigators established organoid cultures from healthy esophageal biopsies and confirmed the esophageal origin of those organoids by qRT-PCR analysis of esophageal-specific gene expression.
[Cell Reports] |
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| Researchers characterized a combinatorial response and the drug combinations sensitized human organoid cultures to the standard‐of‐care chemotherapy paclitaxel.
[EMBO Molecular Medicine] |
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| Scientists revealed that epithelial cells are a major source of elastolytic activity in healthy human colonic tissues and this activity was greatly increased in inflammatory bowel disease patients, both in diseased and distant sites of inflammation.
[Mucosal Immunology] |
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| The authors describe a platform to cultivate muAstV using air–liquid interface cultures derived from mouse enteroids, which supported apical infection and release.
[Mucosal Immunology] |
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| Researchers report a robust protocol for the isolation, maintenance and differentiation of rabbit small intestinal organoids and organoid-derived cell monolayers.
[Scientific Reports] |
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| Investigators provided evidence that human cerebral organoids could be a viable model for Creutzfeldt–Jakob Disease drug screening by using an established anti-prion compound, pentosan polysulfate.
[Scientific Reports] |
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| The transcriptome signature of hESC-derived retinal tissue from retinal organoids maintained for 24 weeks in culture resembled the transcriptome of human fetal retina of more advanced developmental stages.
[Stem Cells and Development] |
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| The authors describe the utilisation of human liver organoid platforms to study Hepatitis B Virus (HBV). They present the different categories of liver organoids and their demonstrated ability to support the complete HBV replication cycle.
[Cancer Letters] |
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| Organoids are emerging as versatile tools to progress the understanding of SARS-CoV-2 biology and to aid in the quest for novel treatments.
[Stem Cell Reports] |
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| Scientists highlight recent advances of neuronal organoid technologies, focusing on the region-specific brain organoids and complementation with endothelial cells and microglia
[Journal of Molecular Medicine] |
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| Kadimastem Ltd. announced that it has been granted a patent by The Israel Patent Office for its differentiated human astrocytes from human pluripotent stem cells for use in the treatment and drug screening of Amyotrophic Lateral Sclerosis (ALS).
[Kadimastem Ltd.] |
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| March 25 – 26, 2021
Virtual |
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| | Helmholtz Association – Tübingen, Germany |
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| | AMOLF – Amsterdam, Netherlands |
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| | Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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