 | | Vol. 2.10 – 18 March, 2021 |
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| To identify mechanisms and cardio-protective drugs, scientists used a state-of-the-art pipeline combining human cardiac organoids with phosphoproteomics and single nuclei RNA sequencing.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers developed a set of computational tools to assess brain organoid patterning, developmental state, and cell identity through comparisons to spatial and single-cell transcriptome reference datasets.
[Cell Stem Cell] |
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| Investigators describe the establishment of long-term 3D organoid culture conditions for mouse and human lacrimal gland.
[Cell Stem Cell] |
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| Scientists found that organoid systems displayed low fidelity to neuroepithelial and early radial glia cell types, but improved as neurogenesis progressed.
[Nature Neuroscience] |
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| Researchers introduced classes of microfabricated 3D frameworks as compliant, multifunctional neural interfaces to spheroids and to assembloids.
[Science Advances] |
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| The authors developed a wound dressing material based on an integrated photo-crosslinking strategy and a microcapsule platform with pulsatile release of TGF-β inhibitor to achieve spatiotemporal specificity for skin wounds.
[Nature Communications] |
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| Scientists present an engineering approach that addressed several existing shortcomings of brain organoids. By culturing brain organoids with a polycaprolactone scaffold, they were able to modify their shape into a flat morphology.
[Biofabrication] |
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| Organoids generated from murine and human small intestine and mouse colon were used to study glucagon-like peptide-1 and peptide YY release.
[Molecular Metabolism] |
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| Researchers investigated a patient-derived thyroid organoid model with the potential to regenerate the thyroid gland.
[Stem Cell Reports] |
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| Scientists generated alveolar organoids derived from human pluripotent stem cells for use as an pulmonary fibrosis model and for drug efficacy evaluation.
[Cell Death Discovery] |
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| The authors investigated the mechanisms by which CD73 might contribute to TNBC progression. This was done by inhibiting CD73 with adenosine 5′-(α, β-methylene) diphosphate in MDA-MB-231 or 4T1 TNBC cells or through shRNA-silencing.
[Scientific Reports] |
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| Researchers describe the expression of brain abundant, membrane-attached signal protein 1 (BASP1), in neural stem cells (NSCs) in the developing and postnatal mammalian brains and human brain organoids, and demonstrated that the NSC-6 antibody may be a useful marker of these cells.
[Scientific Reports] |
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| The authors discuss the available in vitro and in vivo models of MPM and highlight their strengths and limitations. They discuss how newer technologies, such as the tumor-derived organoids, might allow us to address the limitations of existing models.
[Thorax] |
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| Scientists discuss recent advances in LUSC preclinical models, with a focus on genetically engineered mouse models and organoids, in the context of evolving precision medicine and immunotherapy.
[Oncogene] |
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| Brain Canada announced the awarding of a 2019 Platform Support Grant to Dr. Liliana Attisano from the University of Toronto, and team members Jeff Wrana and Laurence Pelletier at the Lunenfeld-Tanenbaum Research Institute. Together with the Krembil Foundation, Brain Canada is awarding $1,425,000 to support the Applied Organoid Core, an organoid production platform for modelling human brain development and disorders.
[Brain Canada Foundation] |
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| Emulate, Inc., launched the Emulate Colon Intestine-Chip for researchers investigating inflammatory intestinal diseases, which will allow researchers to recapitulate specific human colon cell functionality, gain a greater understanding of mechanisms of inflammation, and investigate potential drug targets.
[Emulate, Inc.] |
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| | Gladstone Institute – San Francisco, California, United States |
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| | Helmholtz Association – Tübingen, Germany |
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| | AMOLF – Amsterdam, Netherlands |
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| | Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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