Organoid News Volume 2.12 | Apr 1 2021

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    ON 2.12 | Apr 1 2021


    Organoid News by STEMCELL Technologies
    Vol. 2.12 – 1 April, 2021
    TOP STORY

    Proteasome Stress in Skeletal Muscle Mounts a Long-Range Protective Response That Delays Retinal and Brain Aging

    Maltose preserved proteostasis and neuronal activity in human brain organoids challenged by thermal stress.
    [Cell Metabolism]

    AbstractGraphical Abstract

    Survey results on the needs and challenges in the human pluripotent stem cell field
    PUBLICATIONSRanked by the impact factor of the journal

    Quantifying Single-Cell ERK Dynamics in Colorectal Cancer Organoids Reveals EGFR as an Amplifier of Oncogenic MAPK Pathway Signaling

    To elucidate the interplay between epidermal growth factor signaling and extracellular-regulated kinase activation in tumors, scientists used patient-derived organoids from KRAS and BRAF mutant colorectal cancer.
    [Nature Cell Biology]

    Abstract

    Defective Metabolic Programming Impairs Early Neuronal Morphogenesis in Neural Cultures and an Organoid Model of Leigh Syndrome

    Using patient-derived induced pluripotent stem cells and CRISPR/Cas9 engineering, investigators developed a human model of Leigh syndrom caused by mutations in the complex IV assembly gene SURF1.
    [Nature Communications]

    Full Article

    Reprogramming of the FOXA1 Cistrome in Treatment-Emergent Neuroendocrine Prostate Cancer

    Researchers established the importance of FOXA1 in NEPC and provide a principled approach to identifying cancer dependencies through epigenomic profiling.
    [Nature Communications]

    Full Article

    A Well Plate–Based Multiplexed Platform for Incorporation of Organoids into an Organ-on-a-Chip System with a Perfusable Vasculature

    Investigators describe a detailed alternative method to cultivate millimeter-scale functional vascularized tissues on a biofabricated platform that enabled facile incorporation of organoid technology.
    [Nature Protocols]

    Abstract

    Endothelial Wnts Control Mammary Epithelial Patterning via Fibroblast Signaling

    To enable cell-type-specific gene manipulation in vitro, the authors established an organoid system via coculture of endothelial cells (ECs), fibroblasts, and mammary epithelial cells.
    [Cell Reports]

    Full ArticleGraphical Abstract

    FOXO3 Is a Latent Tumor Suppressor for FOXO3-Positive and Cytoplasmic-Type Gastric Cancer Cells

    Treatment of FOXO3-Cyt human gastric cancer-derived organoids with an AKT inhibitor significantly suppressed the survival and proliferation.
    [Oncogene]

    Full Article

    Emc3 Maintains Intestinal Homeostasis by Preserving Secretory Lineages

    Mitigating endoplasmic reticulum stress with tauroursodeoxycholate acid alleviated secretory dysfunction and restores organoid formation.
    [Mucosal Immunology]

    Full Article

    Lung Organoid Simulations for Modeling and Predicting the Effect of Mutations on SARS-CoV-2 Infectivity

    Researchers suggested that SARS-CoV-2 infection could be simulated in human alveolar type lung cells.
    [Computational and Structural Biotechnology Journal]

    AbstractGraphical Abstract

    HIC1 Represses Atoh1 Transcription and Hair Cell Differentiation in the Cochlea

    In cochlear organoids, Hic1 knockdown induced Atoh1 expression and promoted hair cell differentiation, while Hic1 overexpression hinders differentiation.
    [Stem Cell Research & Therapy]

    Full ArticleGraphical Abstract

    Schlafen 11 Predicts Response to Platinum-Based Chemotherapy in Gastric Cancers

    Scientists investigated the potential clinical utility of SLFN11 in the treatment of gastric cancer (GC). In GC cells and organoids, long-term treatment with oxaliplatin suppressed SLFN11 expression while imparting drug resistance.
    [British Journal of Cancer]

    Abstract

    The Murine Intestinal Stem Cells Are Highly Sensitive to the Modulation of the T3/TRα1-Dependent Pathway

    By using ex vivo 3D organoid cultures and molecular approaches the authors observed early responses to T3 involving the T3-metabolizing enzyme Dio1 and the transporter Mct10, accompanied by a complex response of stem cell- and progenitor-enriched genes.
    [Development]

    Abstract

    Suppression of Elevated Cdc42 Activity Promotes the Regenerative Potential of Aged Intestinal Stem Cells

    Elevation of Cdc42 activity in young animals by genetic means caused premature intestinal stem cell aging, whereas pharmacological suppression of elevated Cdc42 activity restored organoid formation potential in vitro.
    [iScience]

    AbstractGraphical Abstract

    A Genome-Scale CRISPR Cas9 Dropout Screen Identifies Synthetically Lethal Targets in SRC-3 Inhibited Cancer Cells

    Scientists indicated that combined SI-12 and SGI-1027 treatment could achieve stronger inhibition on triple-negative breast cancer organoid formation and growth than single treatment with either compound.
    [Communications Biology]

    Full Article

    Explore scientific events this April with the Science Events Calendar.
    REVIEWS

    Patient-Derived Organoids and High Grade Serous Ovarian Cancer: From Disease Modeling to Personalized Medicine

    Scientists discuss recent studies that have characterized the translational potential of patients’ derived organoids to inform on drug sensitivity of high grade serous ovarian cancer patients.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Heart Organoids and Tissue Models for Modeling Development and Disease

    The authors evaluated recent cardiac organoid studies through the lens of the core principles of organoid technology: patterned self-organization of multiple cell types resembling the in vivo organ.
    [Seminars in Cell & Developmental Biology]

    Abstract

    INDUSTRY AND POLICY NEWS

    $2.5M Award to Fund Joint Organoid Research Program At Wake to Treat Aggressive Cancers

    Personalized medicine research for aggressive abdominal cancers at Wake Forest Baptist Health received a boost from a $2.5 million grant from the National Cancer Institute that supports research efforts at Wake Forest Organoid Research Center.
    [Wake Forest Baptist Health (Newswise, Inc.)]

    Press Release

    FEATURED EVENT

    Engineering Organoids and Organs

    April 26, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Associate / PhD student – Human Gastrointestinal Organoids

    Technische Universität Dresden – Dresden, Germany

    Research Fellow – 3D-Printing & Scaffold Design in ​Neural Tissue

    Nanyang Technological University – Singapore, Singapore

    Stem Cell Core Director – Stem Cell Research

    Gladstone Institute – San Francisco, California, United States

    Research Assistant – Stem Cell Culture for Parkinson’s Disease

    Helmholtz Association – Tübingen, Germany

    Postdoctoral Position – Single-Cell Dynamics in Intestinal Organoids

    AMOLF – Amsterdam, Netherlands

    > See All Jobs

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