 | | Vol. 2.13 – 8 April, 2021 |
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| Investigators showed that microbial polyamines reinforced colonic epithelial proliferation and regulated macrophage differentiation.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that the planar cell polarity protein Vangl2 regulated the distribution of Wnt by cytonemes. They used an organoid formation assay to analyze the requirement for VANGL-dependent WNT cytonemes.
[Nature Communications] |
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| To investigate the role of junctional β-catenin in heme signaling, researchers employed neural organoids with stabilized intercellular junctions and an enhanced capacity for the recruitment of free cytoplasmic β-catenin.
[Cell Reports] |
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| The authors found an increase in AarF domain-containing kinase 1 (ADCK1) expression in clinical specimens of colon cancer and animal models. Downregulation of ADCK1 expression inhibited the colony formation and infiltration of cancer cells, in vivo tumorigenesis, migration, and organoid formation.
[Cell Death & Disease] |
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| Using single‐cell RNA sequencing, researchers explored the transcriptional landscape of a murine organoid model of hereditary diffuse gastric cancer to characterize the impact of CDH1 loss in early tumorigenesis.
[Journal of Pathology] |
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| Scientists succinctly illustrated the three technologies that are closer to clinical translation—namely, human intestinal organoids, sphincter bioengineering and decellularization
[Cytotherapy] |
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| The authors identified preoperative plasma protein biomarkers with the potential to predict early recurrence after resection of pancreatic ductal adenocarcinoma.
[Scientific Reports] |
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| Researchers demonstrated the enhanced anti-cancer activity between two botanical extracts in terms of their ability to inhibit cancer cell growth, suppress colony formation and induce apoptosis. They validated these findings in subcutaneous xenograft models and in patient derived primary epithelial 3D organoids.
[Scientific Reports] |
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| Investigators identified p53 signaling as the central process altered in HUWE1-promoted X-linked intellectual disability syndromes.
[Cell Reports Medicine] |
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| The authors present a protocol to establish a novel human retinoblastoma organoid model derived from genetically engineered human embryonic stem cells.
[STAR Protocols] |
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| Scientists provide a step-by-step protocol for generating fused forebrain organoids derived from human pluripotent stem cells.
[STAR Protocols] |
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| Patient-derived organoids (PDOs) from human tissue samples allow for unique and faithful in vitro modeling of esophageal cancers, and provide an exciting platform for investigation into personalized medicine and targeted treatment approaches
[Cancer Letters] |
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| Scientists specifically address how colon-derived organoids can be perfected as multidimensional, scalable, reproducible models of healthy, pre-neoplastic and neoplastic conditions of the colon.
[Advances in Cancer Research] |
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| The authors highlight key findings from studies that have utilized different human organoid types to investigate the expression of SARS‐CoV‐2 receptors, permissiveness, immune response, dysregulation of cellular functions, and potential antiviral therapeutics.
[Reviews in Medical Virology] |
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| Volastra Therapeutics announced it will collaborate with Microsoft to develop tools that help detect drivers of cancer metastasis. The collaboration will develop automated machine learning tools capable of rapidly and accurately integrating insights across multiple datasets, including pathology slides and 3D tumor-derived organoids.
[Volastra Therapeutics (BusinessWire, Inc.)] |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | Technische Universität Dresden – Dresden, Germany |
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| | Nanyang Technological University – Singapore, Singapore |
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| | Helmholtz Association – Tübingen, Germany |
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| | Gladstone Institute – San Francisco, California, United States |
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